Changes in the response to adrenergic drugs on mouse uterine contractions during pregnancy
The effect of isoproterenol (ISO), norepinephrine (NE) and phenylephrine (PHE) on electrically-induced contractions of mice uterine horns was studied during pregnancy. At the different times of gestation adrenergic agonists always inhibited uterine contractions in the following rank order of potency...
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| Veröffentlicht in: | Life sciences (1973) 1990, Vol.46 (2), p.99-104 |
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| creator | Antonieta Cruz, M. Sepúlveda, Waldo H. Isolde Rudolph, M. |
| description | The effect of isoproterenol (ISO), norepinephrine (NE) and phenylephrine (PHE) on electrically-induced contractions of mice uterine horns was studied during pregnancy. At the different times of gestation adrenergic agonists always inhibited uterine contractions in the following rank order of potency: ISO > NE > PHE. Cumulative dose-response curves constructed for the effect of these amines during diestrous, and at days 3–7, 10–15, 17–21 of gestation, showed that EC
50 values increased gradually as term approached, which could imply a lower capacity of the uterus to respond to adrenergic drugs.
Some likely explanations for this phenomenon are proposed. It is suggested that this lower response to catecholamines at the end of pregnancy could be a cause for the reduced success of
β
2-adrenergic drugs to stop premature labor. |
| doi_str_mv | 10.1016/0024-3205(90)90042-P |
| format | Article |
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50 values increased gradually as term approached, which could imply a lower capacity of the uterus to respond to adrenergic drugs.
Some likely explanations for this phenomenon are proposed. It is suggested that this lower response to catecholamines at the end of pregnancy could be a cause for the reduced success of
β
2-adrenergic drugs to stop premature labor.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(90)90042-P</identifier><identifier>PMID: 1967813</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adrenergic Agonists - pharmacology ; Animals ; Biological and medical sciences ; Electric Stimulation ; Female ; Fundamental and applied biological sciences. Psychology ; Isoproterenol - pharmacology ; Mice ; Mother. Fetoplacental unit. Mammary gland. Milk ; Myometrium - physiology ; norepinephrine ; Norepinephrine - pharmacology ; phenylephrine ; Phenylephrine - pharmacology ; Pregnancy ; Pregnancy, Animal - drug effects ; Pregnancy, Animal - physiology ; Pregnancy. Parturition. Lactation ; Rats ; Rats, Inbred Strains ; Uterine Contraction - drug effects ; uterus ; Vertebrates: reproduction</subject><ispartof>Life sciences (1973), 1990, Vol.46 (2), p.99-104</ispartof><rights>1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4b5667c7216e2d7d7473b5c9142ac3f70e557be0832ca96cc305fce834e0ae203</citedby><cites>FETCH-LOGICAL-c417t-4b5667c7216e2d7d7473b5c9142ac3f70e557be0832ca96cc305fce834e0ae203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/002432059090042P$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6805773$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1967813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antonieta Cruz, M.</creatorcontrib><creatorcontrib>Sepúlveda, Waldo H.</creatorcontrib><creatorcontrib>Isolde Rudolph, M.</creatorcontrib><title>Changes in the response to adrenergic drugs on mouse uterine contractions during pregnancy</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The effect of isoproterenol (ISO), norepinephrine (NE) and phenylephrine (PHE) on electrically-induced contractions of mice uterine horns was studied during pregnancy. At the different times of gestation adrenergic agonists always inhibited uterine contractions in the following rank order of potency: ISO > NE > PHE. Cumulative dose-response curves constructed for the effect of these amines during diestrous, and at days 3–7, 10–15, 17–21 of gestation, showed that EC
50 values increased gradually as term approached, which could imply a lower capacity of the uterus to respond to adrenergic drugs.
Some likely explanations for this phenomenon are proposed. It is suggested that this lower response to catecholamines at the end of pregnancy could be a cause for the reduced success of
β
2-adrenergic drugs to stop premature labor.</description><subject>Adrenergic Agonists - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Isoproterenol - pharmacology</subject><subject>Mice</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Myometrium - physiology</subject><subject>norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>phenylephrine</subject><subject>Phenylephrine - pharmacology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - drug effects</subject><subject>Pregnancy, Animal - physiology</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Uterine Contraction - drug effects</subject><subject>uterus</subject><subject>Vertebrates: reproduction</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhH4DkA0L0kDKOv5ILElpBW6kSPZQLF8s7maRGu85iJ5X673HYVbnRkyW_zzuaeRh7K-BcgDCfAGpVyRr0xxbOWgBVVzfP2Eo0tq3ASPGcrR6Rl-xVzr8AQGsrT9iJaI1thFyxn-s7HwfKPEQ-3RFPlPdjzMSnkfsuUaQ0BORdmofMx8h341zCeaIUInEc45Q8TqFUeDeXv4HvEw3RR3x4zV70fpvpzfE9ZT--fb1dX1bX3y-u1l-uK1TCTpXaaGMs2loYqjvbWWXlRmMrVO1R9hao7LwhaGSNvjWIEnSP1EhF4KkGeco-HObu0_h7pjy5XchI262PVLZ1tjXL2U-DQiuthFIFVAcQ05hzot7tU9j59OAEuMW9W8S6Raxrwf11725K7d1x_rzZUfevdJBd8vfH3Gf02z4VSyE_YqYBbe2CfT5gVKTdB0ouY6CI1IVEOLluDP_f4w-cJaAc</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Antonieta Cruz, M.</creator><creator>Sepúlveda, Waldo H.</creator><creator>Isolde Rudolph, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Changes in the response to adrenergic drugs on mouse uterine contractions during pregnancy</title><author>Antonieta Cruz, M. ; Sepúlveda, Waldo H. ; Isolde Rudolph, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4b5667c7216e2d7d7473b5c9142ac3f70e557be0832ca96cc305fce834e0ae203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adrenergic Agonists - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Isoproterenol - pharmacology</topic><topic>Mice</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Myometrium - physiology</topic><topic>norepinephrine</topic><topic>Norepinephrine - pharmacology</topic><topic>phenylephrine</topic><topic>Phenylephrine - pharmacology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - drug effects</topic><topic>Pregnancy, Animal - physiology</topic><topic>Pregnancy. Parturition. 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At the different times of gestation adrenergic agonists always inhibited uterine contractions in the following rank order of potency: ISO > NE > PHE. Cumulative dose-response curves constructed for the effect of these amines during diestrous, and at days 3–7, 10–15, 17–21 of gestation, showed that EC
50 values increased gradually as term approached, which could imply a lower capacity of the uterus to respond to adrenergic drugs.
Some likely explanations for this phenomenon are proposed. It is suggested that this lower response to catecholamines at the end of pregnancy could be a cause for the reduced success of
β
2-adrenergic drugs to stop premature labor.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>1967813</pmid><doi>10.1016/0024-3205(90)90042-P</doi><tpages>6</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1990, Vol.46 (2), p.99-104 |
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| subjects | Adrenergic Agonists - pharmacology Animals Biological and medical sciences Electric Stimulation Female Fundamental and applied biological sciences. Psychology Isoproterenol - pharmacology Mice Mother. Fetoplacental unit. Mammary gland. Milk Myometrium - physiology norepinephrine Norepinephrine - pharmacology phenylephrine Phenylephrine - pharmacology Pregnancy Pregnancy, Animal - drug effects Pregnancy, Animal - physiology Pregnancy. Parturition. Lactation Rats Rats, Inbred Strains Uterine Contraction - drug effects uterus Vertebrates: reproduction |
| title | Changes in the response to adrenergic drugs on mouse uterine contractions during pregnancy |
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