Effects of adjuvant on neuropeptide-like immunoreactivity in the temporomandibular joint and trigeminal ganglia
To study the role of the nervous system in temporomandibular joint arthritis, substance P-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the trigeminal ganglia and temporomandibular joint of rats was examined. Arthritis was induced in female Lewis rats through bilate...
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| Veröffentlicht in: | Journal of orofacial pain 1997, Vol.11 (3), p.195-199 |
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| container_title | Journal of orofacial pain |
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| creator | Carleson, J Bileviciute, I Theodorsson, E Appelgren, B Appelgren, A Yousef, N Kopp, S Lundeberg, T |
| description | To study the role of the nervous system in temporomandibular joint arthritis, substance P-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the trigeminal ganglia and temporomandibular joint of rats was examined. Arthritis was induced in female Lewis rats through bilateral injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the temporomandibular joint. Control rats received paraffin oil via the same route. Tissues were collected for neuropeptide extraction 28 days after injection and analyzed by radioimmunoassay and reverse-phase high-performance liquid chromatography. Calcitonin gene-related peptide was significantly increased in the arthritic trigeminal ganglia. Substance P, calcitonin gene-related peptide, and neuropeptide Y in the arthritic temporomandibular joint were significantly increased as compared to controls. The results of this study show that sensory and sympathetic neuropeptides may possibly be associated with the development of arthritis in the temporomandibular joint of rats. |
| format | Article |
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Arthritis was induced in female Lewis rats through bilateral injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the temporomandibular joint. Control rats received paraffin oil via the same route. Tissues were collected for neuropeptide extraction 28 days after injection and analyzed by radioimmunoassay and reverse-phase high-performance liquid chromatography. Calcitonin gene-related peptide was significantly increased in the arthritic trigeminal ganglia. Substance P, calcitonin gene-related peptide, and neuropeptide Y in the arthritic temporomandibular joint were significantly increased as compared to controls. The results of this study show that sensory and sympathetic neuropeptides may possibly be associated with the development of arthritis in the temporomandibular joint of rats.</description><identifier>ISSN: 1064-6655</identifier><identifier>PMID: 9610308</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arthritis, Experimental - immunology ; Arthritis, Experimental - metabolism ; Calcitonin Gene-Related Peptide - analysis ; Calcitonin Gene-Related Peptide - immunology ; Chromatography, High Pressure Liquid ; Dentistry ; Female ; Neuroimmunomodulation ; Neuropeptide Y - analysis ; Neuropeptide Y - immunology ; Neuropeptides - analysis ; Radioimmunoassay ; Rats ; Rats, Inbred Lew ; Substance P - analysis ; Substance P - immunology ; Temporomandibular Joint - chemistry ; Temporomandibular Joint - innervation ; Temporomandibular Joint Disorders - immunology ; Temporomandibular Joint Disorders - metabolism ; Trigeminal Ganglion - chemistry</subject><ispartof>Journal of orofacial pain, 1997, Vol.11 (3), p.195-199</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9610308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carleson, J</creatorcontrib><creatorcontrib>Bileviciute, I</creatorcontrib><creatorcontrib>Theodorsson, E</creatorcontrib><creatorcontrib>Appelgren, B</creatorcontrib><creatorcontrib>Appelgren, A</creatorcontrib><creatorcontrib>Yousef, N</creatorcontrib><creatorcontrib>Kopp, S</creatorcontrib><creatorcontrib>Lundeberg, T</creatorcontrib><title>Effects of adjuvant on neuropeptide-like immunoreactivity in the temporomandibular joint and trigeminal ganglia</title><title>Journal of orofacial pain</title><addtitle>J Orofac Pain</addtitle><description>To study the role of the nervous system in temporomandibular joint arthritis, substance P-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the trigeminal ganglia and temporomandibular joint of rats was examined. Arthritis was induced in female Lewis rats through bilateral injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the temporomandibular joint. Control rats received paraffin oil via the same route. Tissues were collected for neuropeptide extraction 28 days after injection and analyzed by radioimmunoassay and reverse-phase high-performance liquid chromatography. Calcitonin gene-related peptide was significantly increased in the arthritic trigeminal ganglia. Substance P, calcitonin gene-related peptide, and neuropeptide Y in the arthritic temporomandibular joint were significantly increased as compared to controls. The results of this study show that sensory and sympathetic neuropeptides may possibly be associated with the development of arthritis in the temporomandibular joint of rats.</description><subject>Animals</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritis, Experimental - metabolism</subject><subject>Calcitonin Gene-Related Peptide - analysis</subject><subject>Calcitonin Gene-Related Peptide - immunology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dentistry</subject><subject>Female</subject><subject>Neuroimmunomodulation</subject><subject>Neuropeptide Y - analysis</subject><subject>Neuropeptide Y - immunology</subject><subject>Neuropeptides - analysis</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Substance P - analysis</subject><subject>Substance P - immunology</subject><subject>Temporomandibular Joint - chemistry</subject><subject>Temporomandibular Joint - innervation</subject><subject>Temporomandibular Joint Disorders - immunology</subject><subject>Temporomandibular Joint Disorders - metabolism</subject><subject>Trigeminal Ganglion - chemistry</subject><issn>1064-6655</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkL1qwzAYRT20pGnaRyho6maQLUuOxxLSHwhkaWfzSfqUKrUkVz-BvH0DzXQ5cDjDvamWDRVdLQTnd9V9SkdK26ZrxaJaDKKhjK6XVdgagyonEgwBfSwn8JkETzyWGGacs9VYT_YHiXWu-BARVLYnm8_EepK_kWR0c4jBgddWlgkiOQZ7iVyY5GgP6KyHiRzAHyYLD9WtgSnh43VX1dfr9nPzXu_2bx-bl109N22Ta6mAGdoODFB0lKGExvQKORUAshGyN0MvO8q51KCpXA99pzho7FSLgg2Mrarn_-4cw2_BlEdnk8JpAo-hpLEfBOWtaC_i01Us0qEe52gdxPN4fYj9AdsuZLE</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Carleson, J</creator><creator>Bileviciute, I</creator><creator>Theodorsson, E</creator><creator>Appelgren, B</creator><creator>Appelgren, A</creator><creator>Yousef, N</creator><creator>Kopp, S</creator><creator>Lundeberg, T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Effects of adjuvant on neuropeptide-like immunoreactivity in the temporomandibular joint and trigeminal ganglia</title><author>Carleson, J ; Bileviciute, I ; Theodorsson, E ; Appelgren, B ; Appelgren, A ; Yousef, N ; Kopp, S ; Lundeberg, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-bca3f0293ae6403eba1f7ce506aab16b7f97b4055bdad0b8974c5ade4c2e63933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Arthritis, Experimental - immunology</topic><topic>Arthritis, Experimental - metabolism</topic><topic>Calcitonin Gene-Related Peptide - analysis</topic><topic>Calcitonin Gene-Related Peptide - immunology</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dentistry</topic><topic>Female</topic><topic>Neuroimmunomodulation</topic><topic>Neuropeptide Y - analysis</topic><topic>Neuropeptide Y - immunology</topic><topic>Neuropeptides - analysis</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Substance P - analysis</topic><topic>Substance P - immunology</topic><topic>Temporomandibular Joint - chemistry</topic><topic>Temporomandibular Joint - innervation</topic><topic>Temporomandibular Joint Disorders - immunology</topic><topic>Temporomandibular Joint Disorders - metabolism</topic><topic>Trigeminal Ganglion - chemistry</topic><toplevel>online_resources</toplevel><creatorcontrib>Carleson, J</creatorcontrib><creatorcontrib>Bileviciute, I</creatorcontrib><creatorcontrib>Theodorsson, E</creatorcontrib><creatorcontrib>Appelgren, B</creatorcontrib><creatorcontrib>Appelgren, A</creatorcontrib><creatorcontrib>Yousef, N</creatorcontrib><creatorcontrib>Kopp, S</creatorcontrib><creatorcontrib>Lundeberg, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orofacial pain</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carleson, J</au><au>Bileviciute, I</au><au>Theodorsson, E</au><au>Appelgren, B</au><au>Appelgren, A</au><au>Yousef, N</au><au>Kopp, S</au><au>Lundeberg, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of adjuvant on neuropeptide-like immunoreactivity in the temporomandibular joint and trigeminal ganglia</atitle><jtitle>Journal of orofacial pain</jtitle><addtitle>J Orofac Pain</addtitle><date>1997</date><risdate>1997</risdate><volume>11</volume><issue>3</issue><spage>195</spage><epage>199</epage><pages>195-199</pages><issn>1064-6655</issn><abstract>To study the role of the nervous system in temporomandibular joint arthritis, substance P-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the trigeminal ganglia and temporomandibular joint of rats was examined. Arthritis was induced in female Lewis rats through bilateral injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the temporomandibular joint. Control rats received paraffin oil via the same route. Tissues were collected for neuropeptide extraction 28 days after injection and analyzed by radioimmunoassay and reverse-phase high-performance liquid chromatography. Calcitonin gene-related peptide was significantly increased in the arthritic trigeminal ganglia. Substance P, calcitonin gene-related peptide, and neuropeptide Y in the arthritic temporomandibular joint were significantly increased as compared to controls. The results of this study show that sensory and sympathetic neuropeptides may possibly be associated with the development of arthritis in the temporomandibular joint of rats.</abstract><cop>United States</cop><pmid>9610308</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Journal of orofacial pain, 1997, Vol.11 (3), p.195-199 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Arthritis, Experimental - immunology Arthritis, Experimental - metabolism Calcitonin Gene-Related Peptide - analysis Calcitonin Gene-Related Peptide - immunology Chromatography, High Pressure Liquid Dentistry Female Neuroimmunomodulation Neuropeptide Y - analysis Neuropeptide Y - immunology Neuropeptides - analysis Radioimmunoassay Rats Rats, Inbred Lew Substance P - analysis Substance P - immunology Temporomandibular Joint - chemistry Temporomandibular Joint - innervation Temporomandibular Joint Disorders - immunology Temporomandibular Joint Disorders - metabolism Trigeminal Ganglion - chemistry |
| title | Effects of adjuvant on neuropeptide-like immunoreactivity in the temporomandibular joint and trigeminal ganglia |
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