Long-term follow-up of hypopituitary patients treated with human growth hormone
Thirty-six former human growth hormone (hGH) recipients underwent comprehensive physical, endocrine and lipoprotein evaluations as adults. Treatment was associated with a decrease in height standard deviation score (SDS) in males from 4.0 pretreatment to 2.1 as adults, and in females from 4.2 to 2.5...
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| Veröffentlicht in: | Medicine (Baltimore) 1990-01, Vol.69 (1), p.46-55 |
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| creator | Libber, S M Plotnick, L P Johanson, A J Blizzard, R M Kwiterovich, P O Migeon, C J |
| description | Thirty-six former human growth hormone (hGH) recipients underwent comprehensive physical, endocrine and lipoprotein evaluations as adults. Treatment was associated with a decrease in height standard deviation score (SDS) in males from 4.0 pretreatment to 2.1 as adults, and in females from 4.2 to 2.5. Males showed a better growth response to treatment than did females. Plasma somatomedin-C levels were subnormal in 30 patients, but were higher in isolated growth-hormone-deficient patients than in others. Three men and 1 woman showed evidence suggesting a disturbance in pulsatile gonadotropin release despite the previous documentation of normal serum gonadotropin levels. Hypertriglyceridemia was not observed, and the women's plasma cholesterol levels were unremarkable. Men, however, showed higher-than-expected total cholesterol, LDL-cholesterol, and HDL-cholesterol concentrations. The last finding may explain the lack of increased cardiovascular morbidity in this group. |
| doi_str_mv | 10.1097/00005792-199001000-00004 |
| format | Article |
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Treatment was associated with a decrease in height standard deviation score (SDS) in males from 4.0 pretreatment to 2.1 as adults, and in females from 4.2 to 2.5. Males showed a better growth response to treatment than did females. Plasma somatomedin-C levels were subnormal in 30 patients, but were higher in isolated growth-hormone-deficient patients than in others. Three men and 1 woman showed evidence suggesting a disturbance in pulsatile gonadotropin release despite the previous documentation of normal serum gonadotropin levels. Hypertriglyceridemia was not observed, and the women's plasma cholesterol levels were unremarkable. Men, however, showed higher-than-expected total cholesterol, LDL-cholesterol, and HDL-cholesterol concentrations. 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The last finding may explain the lack of increased cardiovascular morbidity in this group.</description><subject>Adolescent</subject><subject>Adrenal Cortex Function Tests</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Female</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Hypopituitarism - blood</subject><subject>Hypopituitarism - drug therapy</subject><subject>Hypopituitarism - physiopathology</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ovary - physiopathology</subject><subject>Testis - physiopathology</subject><subject>Testosterone - blood</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Hormones - blood</subject><issn>0025-7974</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwzAQ9AFUSuETkHziZvAzjo-oAopUqRc4R44fbVASB9tR1b8npaV7Wc3szK52AIAEPxGs5DOeSkhFEVEKYzIhdKT4FZhjTAWSSvIbcJvS9zRlkvIZmFGqlJLFHGzWod-i7GIHfWjbsEfjAIOHu8MQhiaPTdbxAAedG9fnBHN0OjsL903ewd3Y6R5uY9gfQYhd6N0duPa6Te7-3Bfg6-31c7lC6837x_JljQwrVUZCcyEI1bimpa6NFc5a47W2XteKEoaJpWXtDTeMC08tE0JhYkrrhC04U2wBHk97hxh-Rpdy1TXJuLbVvQtjqqQqMC-UnITlSWhiSCk6Xw2x6aanKoKrY37Vf37VJb8_ik_Wh_ONse6cvRjP4bFfdyRvGg</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Libber, S M</creator><creator>Plotnick, L P</creator><creator>Johanson, A J</creator><creator>Blizzard, R M</creator><creator>Kwiterovich, P O</creator><creator>Migeon, C J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199001</creationdate><title>Long-term follow-up of hypopituitary patients treated with human growth hormone</title><author>Libber, S M ; Plotnick, L P ; Johanson, A J ; Blizzard, R M ; Kwiterovich, P O ; Migeon, C J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-5a45512a0b28abcd5eddcfaadfab921301d28bfc4c345f2d355901c8de5d64393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adrenal Cortex Function Tests</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Female</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Hypopituitarism - blood</topic><topic>Hypopituitarism - drug therapy</topic><topic>Hypopituitarism - physiopathology</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ovary - physiopathology</topic><topic>Testis - physiopathology</topic><topic>Testosterone - blood</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Hormones - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Libber, S M</creatorcontrib><creatorcontrib>Plotnick, L P</creatorcontrib><creatorcontrib>Johanson, A J</creatorcontrib><creatorcontrib>Blizzard, R M</creatorcontrib><creatorcontrib>Kwiterovich, P O</creatorcontrib><creatorcontrib>Migeon, C J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Libber, S M</au><au>Plotnick, L P</au><au>Johanson, A J</au><au>Blizzard, R M</au><au>Kwiterovich, P O</au><au>Migeon, C J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term follow-up of hypopituitary patients treated with human growth hormone</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>1990-01</date><risdate>1990</risdate><volume>69</volume><issue>1</issue><spage>46</spage><epage>55</epage><pages>46-55</pages><issn>0025-7974</issn><abstract>Thirty-six former human growth hormone (hGH) recipients underwent comprehensive physical, endocrine and lipoprotein evaluations as adults. 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| fulltext | fulltext |
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| ispartof | Medicine (Baltimore), 1990-01, Vol.69 (1), p.46-55 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_79604697 |
| source | MEDLINE; Journals@Ovid Complete; Wolters Kluwer Open Health; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adrenal Cortex Function Tests Adult Anthropometry Female Growth Hormone - therapeutic use Humans Hypopituitarism - blood Hypopituitarism - drug therapy Hypopituitarism - physiopathology Insulin-Like Growth Factor I - analysis Lipids - blood Male Middle Aged Ovary - physiopathology Testis - physiopathology Testosterone - blood Thyroid Function Tests Thyroid Hormones - blood |
| title | Long-term follow-up of hypopituitary patients treated with human growth hormone |
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