Transfer of Zidovudine (AZT) by Human Placenta

The transfer of zidovudine (AZT) across human placenta was studied using an in vitro perfusion system with independent maternal and fetal circulations. AZT is transferred toward the fetus more rapidly than L-glucose (transfer index 1.5), a water-soluble molecule smaller than AZT(267 vs. 180Da) that...

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Veröffentlicht in:	The Journal of infectious diseases 1990-02, Vol.161 (2), p.203-207
Hauptverfasser:	Liebes, Leonard, Mendoza, Sandra, Wilson, David, Dancis, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS related complex AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Chromatography, High Pressure Liquid Elution Female Fetus Glucose - pharmacokinetics Glucuronides Humans Major Articles Maternal-Fetal Exchange Medical sciences Nucleosides Organ Culture Techniques Perfusion Pharmacology. Drug treatments Placenta Placenta - metabolism Pregnancy Radioactive decay Transfer rates Zidovudine - pharmacokinetics Zidovudine - therapeutic use
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