Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins
SENSORY transduction in taste and olfaction, the principal chemical senses, seems to be mediated by membrane-associated proteins on the apical surfaces of the respective receptor cells 1,2 . The recent isolation and characterization of soluble 'odorant-binding proteins9 secreted from the nasal...
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| Veröffentlicht in: | Nature (London) 1990-01, Vol.343 (6256), p.366-369 |
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| description | SENSORY transduction in taste and olfaction, the principal chemical senses, seems to be mediated by membrane-associated proteins on the apical surfaces of the respective receptor cells
1,2
. The recent isolation and characterization of soluble 'odorant-binding proteins9 secreted from the nasal glands of rat
3
, cow
4
and frog
5
, led to the hypothesis that these proteins function as necessary cofactors in olfactory transduction by concentrating and delivering odorants to the receptors
6
. The primary reception of taste stimuli occurs in specialized neuroepithelial receptor cells bundled in taste buds that are clustered in various types of papillae in the lingual epithelium of the tongue
7
. Small tubulo-alveolar salivary glands, the von Ebner's glands, are located beneath the circumvallate and the foliate papillae. Their ducts open exclusively into the trough at the base of the papillae
8,9
. Taste buds located in the medial and lateral walls of the papillae open with their taste pores into the trough and consequently are in direct contact with the secretions of von Ebner's glands. Here we report the molecular cloning and characterization of a protein of relative molecular mass 18,000 that is highly expressed in von Ebner's glands. Like the odorant-binding proteins, this protein shows similarity to members of a protein superfamily of hydrophobic molecule transporters, indicating that pre-receptor events could also be necessary for the concentration and delivery of sapid molecules in the gustatory system, and emphasizing the close relationship of taste and olfaction. |
| doi_str_mv | 10.1038/343366a0 |
| format | Article |
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1,2
. The recent isolation and characterization of soluble 'odorant-binding proteins9 secreted from the nasal glands of rat
3
, cow
4
and frog
5
, led to the hypothesis that these proteins function as necessary cofactors in olfactory transduction by concentrating and delivering odorants to the receptors
6
. The primary reception of taste stimuli occurs in specialized neuroepithelial receptor cells bundled in taste buds that are clustered in various types of papillae in the lingual epithelium of the tongue
7
. Small tubulo-alveolar salivary glands, the von Ebner's glands, are located beneath the circumvallate and the foliate papillae. Their ducts open exclusively into the trough at the base of the papillae
8,9
. Taste buds located in the medial and lateral walls of the papillae open with their taste pores into the trough and consequently are in direct contact with the secretions of von Ebner's glands. Here we report the molecular cloning and characterization of a protein of relative molecular mass 18,000 that is highly expressed in von Ebner's glands. Like the odorant-binding proteins, this protein shows similarity to members of a protein superfamily of hydrophobic molecule transporters, indicating that pre-receptor events could also be necessary for the concentration and delivery of sapid molecules in the gustatory system, and emphasizing the close relationship of taste and olfaction.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/343366a0</identifier><identifier>PMID: 1689010</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alveoli ; Amino Acid Sequence ; Amino acids ; Animals ; Base Sequence ; Binding ; Biological and medical sciences ; Carrier Proteins ; Cloning ; Cloning, Molecular ; Cofactors ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Ducts ; Epithelium ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; genes ; Gustatory system ; Homology ; Humanities and Social Sciences ; Hydrophobicity ; letter ; Ligands ; Lingual epithelium ; Lipocalin 1 ; Lipophilic ; Male ; Molecular Sequence Data ; Molecular Weight ; Molecules ; multidisciplinary ; Neurobiology ; Neurosciences ; Odorants ; Olfaction ; Olfactory system and olfaction. Gustatory system and gustation ; Oocytes - metabolism ; Organic chemistry ; Papillae ; Peptides ; Physiology ; Poly A - genetics ; Poly A - isolation & purification ; Protein Biosynthesis ; Proteins ; Rats ; RNA - analysis ; RNA - genetics ; RNA - isolation & purification ; RNA, Messenger ; Salivary gland ; Salivary glands ; Salivary Glands - analysis ; Salivary Glands - metabolism ; Salivary Proteins and Peptides - genetics ; Salivary Proteins and Peptides - physiology ; Science ; Science (multidisciplinary) ; Secretions ; Senses ; Sensory transduction ; Sequence Homology, Nucleic Acid ; Smell ; Taste ; Taste - physiology ; Taste buds ; Taste stimuli ; Transfection ; Trends ; Vertebrates: nervous system and sense organs ; Xenopus laevis</subject><ispartof>Nature (London), 1990-01, Vol.343 (6256), p.366-369</ispartof><rights>Springer Nature Limited 1990</rights><rights>1991 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Jan 25, 1990</rights><rights>Copyright Nature Publishing Group Jan 25, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-206c2499f732f4800720758f3fa9a4bec4f0e1135bac0ddb255438d7cf6881e23</citedby><cites>FETCH-LOGICAL-c549t-206c2499f732f4800720758f3fa9a4bec4f0e1135bac0ddb255438d7cf6881e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/343366a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/343366a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19339227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1689010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmale, Hartwig</creatorcontrib><creatorcontrib>Holtgreve-Grez, Heidi</creatorcontrib><creatorcontrib>Christiansen, Heidje</creatorcontrib><title>Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>SENSORY transduction in taste and olfaction, the principal chemical senses, seems to be mediated by membrane-associated proteins on the apical surfaces of the respective receptor cells
1,2
. The recent isolation and characterization of soluble 'odorant-binding proteins9 secreted from the nasal glands of rat
3
, cow
4
and frog
5
, led to the hypothesis that these proteins function as necessary cofactors in olfactory transduction by concentrating and delivering odorants to the receptors
6
. The primary reception of taste stimuli occurs in specialized neuroepithelial receptor cells bundled in taste buds that are clustered in various types of papillae in the lingual epithelium of the tongue
7
. Small tubulo-alveolar salivary glands, the von Ebner's glands, are located beneath the circumvallate and the foliate papillae. Their ducts open exclusively into the trough at the base of the papillae
8,9
. Taste buds located in the medial and lateral walls of the papillae open with their taste pores into the trough and consequently are in direct contact with the secretions of von Ebner's glands. Here we report the molecular cloning and characterization of a protein of relative molecular mass 18,000 that is highly expressed in von Ebner's glands. Like the odorant-binding proteins, this protein shows similarity to members of a protein superfamily of hydrophobic molecule transporters, indicating that pre-receptor events could also be necessary for the concentration and delivery of sapid molecules in the gustatory system, and emphasizing the close relationship of taste and olfaction.</description><subject>Alveoli</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Cofactors</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Ducts</subject><subject>Epithelium</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>genes</subject><subject>Gustatory system</subject><subject>Homology</subject><subject>Humanities and Social Sciences</subject><subject>Hydrophobicity</subject><subject>letter</subject><subject>Ligands</subject><subject>Lingual epithelium</subject><subject>Lipocalin 1</subject><subject>Lipophilic</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Molecules</subject><subject>multidisciplinary</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Odorants</subject><subject>Olfaction</subject><subject>Olfactory system and olfaction. Gustatory system and gustation</subject><subject>Oocytes - metabolism</subject><subject>Organic chemistry</subject><subject>Papillae</subject><subject>Peptides</subject><subject>Physiology</subject><subject>Poly A - genetics</subject><subject>Poly A - isolation & purification</subject><subject>Protein Biosynthesis</subject><subject>Proteins</subject><subject>Rats</subject><subject>RNA - analysis</subject><subject>RNA - genetics</subject><subject>RNA - isolation & purification</subject><subject>RNA, Messenger</subject><subject>Salivary gland</subject><subject>Salivary glands</subject><subject>Salivary Glands - analysis</subject><subject>Salivary Glands - metabolism</subject><subject>Salivary Proteins and Peptides - genetics</subject><subject>Salivary Proteins and Peptides - physiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Secretions</subject><subject>Senses</subject><subject>Sensory transduction</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Smell</subject><subject>Taste</subject><subject>Taste - physiology</subject><subject>Taste buds</subject><subject>Taste stimuli</subject><subject>Transfection</subject><subject>Trends</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Xenopus laevis</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkluL1DAUgIMo6-wq-AeU4uLtoXpyaS6PsniDBX3Q55KmyWyWTFOTVpl_b0pnd0C8hJBAzsd3cnKC0CMMrzFQ-YYySjnXcAdtMBO8ZlyKu2gDQGQNkvL76DTnawBosGAn6ARzqQDDBv38EnP2XbBVimVxMVVZB_9Dp321DXroqzHFyfqhKnPSeSqgNXacfFyOem_0ZPuq21dXcRdD3O6rKVbBj3G88sGbOvjtYjE6JW_TjS0_QPecDtk-POxn6Nv7d18vPtaXnz98unh7WZuGqakmwA1hSjlBiWMSQBAQjXTUaaVZZw1zYDGmTacN9H1HmoZR2QvjuJTYEnqGnq_ekvj7bPPU7nw2NpTSbJxzKxQH3AhWwBf_BssLK0XL-J8SN4xxAovy_DfwOs5pKOW2hFDChBJk0T39KwWMEVB8gV6ukEmlX8m6dkx-V5rUYmiXH9De_ICCPj745m5n-yO4trzEnx3iOhsdXNKD8fmIlRoVIaJwr1Yul9Cwtel4rz_kfLKyg57mZG9lt8Avys3ORQ</recordid><startdate>19900125</startdate><enddate>19900125</enddate><creator>Schmale, Hartwig</creator><creator>Holtgreve-Grez, Heidi</creator><creator>Christiansen, Heidje</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>M81</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19900125</creationdate><title>Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins</title><author>Schmale, Hartwig ; Holtgreve-Grez, Heidi ; Christiansen, Heidje</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-206c2499f732f4800720758f3fa9a4bec4f0e1135bac0ddb255438d7cf6881e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alveoli</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Cofactors</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>Ducts</topic><topic>Epithelium</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>genes</topic><topic>Gustatory system</topic><topic>Homology</topic><topic>Humanities and Social Sciences</topic><topic>Hydrophobicity</topic><topic>letter</topic><topic>Ligands</topic><topic>Lingual epithelium</topic><topic>Lipocalin 1</topic><topic>Lipophilic</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>Molecules</topic><topic>multidisciplinary</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Odorants</topic><topic>Olfaction</topic><topic>Olfactory system and olfaction. Gustatory system and gustation</topic><topic>Oocytes - metabolism</topic><topic>Organic chemistry</topic><topic>Papillae</topic><topic>Peptides</topic><topic>Physiology</topic><topic>Poly A - genetics</topic><topic>Poly A - isolation & purification</topic><topic>Protein Biosynthesis</topic><topic>Proteins</topic><topic>Rats</topic><topic>RNA - analysis</topic><topic>RNA - genetics</topic><topic>RNA - isolation & purification</topic><topic>RNA, Messenger</topic><topic>Salivary gland</topic><topic>Salivary glands</topic><topic>Salivary Glands - analysis</topic><topic>Salivary Glands - metabolism</topic><topic>Salivary Proteins and Peptides - genetics</topic><topic>Salivary Proteins and Peptides - physiology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Secretions</topic><topic>Senses</topic><topic>Sensory transduction</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Smell</topic><topic>Taste</topic><topic>Taste - physiology</topic><topic>Taste 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Heidje</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1990-01-25</date><risdate>1990</risdate><volume>343</volume><issue>6256</issue><spage>366</spage><epage>369</epage><pages>366-369</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>SENSORY transduction in taste and olfaction, the principal chemical senses, seems to be mediated by membrane-associated proteins on the apical surfaces of the respective receptor cells
1,2
. The recent isolation and characterization of soluble 'odorant-binding proteins9 secreted from the nasal glands of rat
3
, cow
4
and frog
5
, led to the hypothesis that these proteins function as necessary cofactors in olfactory transduction by concentrating and delivering odorants to the receptors
6
. The primary reception of taste stimuli occurs in specialized neuroepithelial receptor cells bundled in taste buds that are clustered in various types of papillae in the lingual epithelium of the tongue
7
. Small tubulo-alveolar salivary glands, the von Ebner's glands, are located beneath the circumvallate and the foliate papillae. Their ducts open exclusively into the trough at the base of the papillae
8,9
. Taste buds located in the medial and lateral walls of the papillae open with their taste pores into the trough and consequently are in direct contact with the secretions of von Ebner's glands. Here we report the molecular cloning and characterization of a protein of relative molecular mass 18,000 that is highly expressed in von Ebner's glands. Like the odorant-binding proteins, this protein shows similarity to members of a protein superfamily of hydrophobic molecule transporters, indicating that pre-receptor events could also be necessary for the concentration and delivery of sapid molecules in the gustatory system, and emphasizing the close relationship of taste and olfaction.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1689010</pmid><doi>10.1038/343366a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1990-01, Vol.343 (6256), p.366-369 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79601574 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Alveoli Amino Acid Sequence Amino acids Animals Base Sequence Binding Biological and medical sciences Carrier Proteins Cloning Cloning, Molecular Cofactors Deoxyribonucleic acid DNA DNA - genetics Ducts Epithelium Fundamental and applied biological sciences. Psychology Gene Expression genes Gustatory system Homology Humanities and Social Sciences Hydrophobicity letter Ligands Lingual epithelium Lipocalin 1 Lipophilic Male Molecular Sequence Data Molecular Weight Molecules multidisciplinary Neurobiology Neurosciences Odorants Olfaction Olfactory system and olfaction. Gustatory system and gustation Oocytes - metabolism Organic chemistry Papillae Peptides Physiology Poly A - genetics Poly A - isolation & purification Protein Biosynthesis Proteins Rats RNA - analysis RNA - genetics RNA - isolation & purification RNA, Messenger Salivary gland Salivary glands Salivary Glands - analysis Salivary Glands - metabolism Salivary Proteins and Peptides - genetics Salivary Proteins and Peptides - physiology Science Science (multidisciplinary) Secretions Senses Sensory transduction Sequence Homology, Nucleic Acid Smell Taste Taste - physiology Taste buds Taste stimuli Transfection Trends Vertebrates: nervous system and sense organs Xenopus laevis |
| title | Possible role for salivary gland protein in taste reception indicated by homology to lipophilic-ligand carrier proteins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T12%3A03%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Possible%20role%20for%20salivary%20gland%20protein%20in%20taste%20reception%20indicated%20by%20homology%20to%20lipophilic-ligand%20carrier%20proteins&rft.jtitle=Nature%20(London)&rft.au=Schmale,%20Hartwig&rft.date=1990-01-25&rft.volume=343&rft.issue=6256&rft.spage=366&rft.epage=369&rft.pages=366-369&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/343366a0&rft_dat=%3Cproquest_cross%3E15446204%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204420963&rft_id=info:pmid/1689010&rfr_iscdi=true |