Molecular Relapse in Chronic Myelogenous Leukemia Patients After Bone Marrow Transplantation Detected by Polymerase Chain Reaction

Relapse of chronic myelogenous leukemia after bone marrow transplantation can be detected by using clinical, cytogenetic, or molecular tools. A modification of the polymerase chain reaction can be used in patients to detect low levels of the BCR-ABL-encoded mRNA transcript, a specific marker for chr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1990-01, Vol.87 (2), p.563-567
Hauptverfasser:	Sawyers, Charles L., Timson, Lisa, Kawasaki, Ernest S., Clark, Steven S., Witte, Owen N., Champlin, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	550401 - Genetics- Tracer Techniques ANIMAL CELLS ANIMAL TISSUES Base Sequence BASIC BIOLOGICAL SCIENCES BIOCHEMISTRY Biological and medical sciences Biomarkers, Tumor - analysis BIOSYNTHESIS Blast Crisis - diagnosis Blood BODY BONE MARROW BONE MARROW CELLS Bone Marrow Transplantation CHEMISTRY CHROMOSOMES Chronic myeloid leukemia CONNECTIVE TISSUE CELLS CYTOCHEMISTRY Cytogenetics DISEASES DNA POLYMERASES ENZYMES Follow-Up Studies Fusion Proteins, bcr-abl - genetics GENE AMPLIFICATION Hematologic and hematopoietic diseases HEMATOPOIETIC SYSTEM HEMIC DISEASES Humans IMMUNE SYSTEM DISEASES LEUKEMIA Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences MESSENGER-RNA Metaphase Molecular Sequence Data NEOPLASMS Nucleic Acid Amplification Techniques NUCLEIC ACIDS NUCLEOTIDYLTRANSFERASES Oligonucleotide Probes OLIGONUCLEOTIDES ORGANIC COMPOUNDS ORGANS PATIENTS PHILADELPHIA CHROMOSOME PHOSPHORUS-GROUP TRANSFERASES Polymerase chain reaction Polymerase Chain Reaction - methods POLYMERASES Recurrence Relapse RNA RNA, Messenger - analysis RNA, Messenger - genetics SOMATIC CELLS SYNTHESIS Tissue grafting TISSUES TRANSCRIPTION TRANSFERASES TRANSPLANTS TUMOR CELLS
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