Perinatal Factors Predicting Severe Intracranial Hemorrhage
ABSTRACT The objective of this paper is to determine the importance of perinatal factors predicting occurrence of severe intracranial hemorrhage (ICH) in premature new-borns. A post-hoc analysis of a previously published randomized, double-blinded, prospective trial was performed. Logistic regressio...
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| Veröffentlicht in: | American journal of perinatology 1997-11, Vol.14 (10), p.631-636 |
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| container_title | American journal of perinatology |
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| creator | Thorp, James A. Poskin, Mary F. McKenzie, David R. Heimes, Brian |
| description | ABSTRACT
The objective of this paper is to determine the importance of perinatal factors predicting occurrence of severe intracranial hemorrhage (ICH) in premature new-borns. A post-hoc analysis of a previously published randomized, double-blinded, prospective trial was performed. Logistic regression analysis was used to assess the importance of obstetrical variables and umbilical cord blood coagulation studies and acid-base status in predicting severe ICH (grades 3 and 4). The trial lasted 42 months; 401 pregnant women were invited to participate and 48 declined. The most important predictors of severe ICH in order of decreasing significance were: gestational age at delivery (P = 0.0001), duration of painful labor (P = 0.0077), duration of antenatal antibiotic therapy (P = 0.0203), maternal age (P = 0.0247), and factor X activity in umbilical cord blood (P = 0.0302). Mode of delivery, cord blood acid-base, and coagulation status did not correlate with severe ICH. The majority of severe ICHs were late in onset; only two of 31 were known to have occurred in the first 24 hr of life. Gestational age, duration of painful labor, duration of antibiotic therapy, and maternal age were the most important predictors of severe ICH. |
| doi_str_mv | 10.1055/s-2008-1040767 |
| format | Article |
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The objective of this paper is to determine the importance of perinatal factors predicting occurrence of severe intracranial hemorrhage (ICH) in premature new-borns. A post-hoc analysis of a previously published randomized, double-blinded, prospective trial was performed. Logistic regression analysis was used to assess the importance of obstetrical variables and umbilical cord blood coagulation studies and acid-base status in predicting severe ICH (grades 3 and 4). The trial lasted 42 months; 401 pregnant women were invited to participate and 48 declined. The most important predictors of severe ICH in order of decreasing significance were: gestational age at delivery (P = 0.0001), duration of painful labor (P = 0.0077), duration of antenatal antibiotic therapy (P = 0.0203), maternal age (P = 0.0247), and factor X activity in umbilical cord blood (P = 0.0302). Mode of delivery, cord blood acid-base, and coagulation status did not correlate with severe ICH. The majority of severe ICHs were late in onset; only two of 31 were known to have occurred in the first 24 hr of life. Gestational age, duration of painful labor, duration of antibiotic therapy, and maternal age were the most important predictors of severe ICH.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2008-1040767</identifier><identifier>PMID: 9605251</identifier><identifier>CODEN: AJPEEK</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cerebral Hemorrhage - blood ; Cerebral Hemorrhage - diagnosis ; Cerebral Hemorrhage - etiology ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature, Diseases - blood ; Infant, Premature, Diseases - diagnosis ; Infant, Premature, Diseases - etiology ; Intensive care medicine ; Logistic Models ; Male ; Maternal Age ; Medical sciences ; Obstetric Labor, Premature - blood ; Obstetric Labor, Premature - complications ; ORIGINAL ARTICLE ; Pregnancy ; Randomized Controlled Trials as Topic ; Risk ; Risk Factors ; Time Factors</subject><ispartof>American journal of perinatology, 1997-11, Vol.14 (10), p.631-636</ispartof><rights>1997 by Thieme Medical Publishers, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2727-60de23974a7539bb3a9301a37424d0757f4ac8c731bb456c06e175b9888b007e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2008-1040767.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2008-1040767$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2070359$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9605251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thorp, James A.</creatorcontrib><creatorcontrib>Poskin, Mary F.</creatorcontrib><creatorcontrib>McKenzie, David R.</creatorcontrib><creatorcontrib>Heimes, Brian</creatorcontrib><title>Perinatal Factors Predicting Severe Intracranial Hemorrhage</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
The objective of this paper is to determine the importance of perinatal factors predicting occurrence of severe intracranial hemorrhage (ICH) in premature new-borns. A post-hoc analysis of a previously published randomized, double-blinded, prospective trial was performed. Logistic regression analysis was used to assess the importance of obstetrical variables and umbilical cord blood coagulation studies and acid-base status in predicting severe ICH (grades 3 and 4). The trial lasted 42 months; 401 pregnant women were invited to participate and 48 declined. The most important predictors of severe ICH in order of decreasing significance were: gestational age at delivery (P = 0.0001), duration of painful labor (P = 0.0077), duration of antenatal antibiotic therapy (P = 0.0203), maternal age (P = 0.0247), and factor X activity in umbilical cord blood (P = 0.0302). Mode of delivery, cord blood acid-base, and coagulation status did not correlate with severe ICH. The majority of severe ICHs were late in onset; only two of 31 were known to have occurred in the first 24 hr of life. Gestational age, duration of painful labor, duration of antibiotic therapy, and maternal age were the most important predictors of severe ICH.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cerebral Hemorrhage - blood</subject><subject>Cerebral Hemorrhage - diagnosis</subject><subject>Cerebral Hemorrhage - etiology</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infant, Premature, Diseases - diagnosis</subject><subject>Infant, Premature, Diseases - etiology</subject><subject>Intensive care medicine</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Obstetric Labor, Premature - blood</subject><subject>Obstetric Labor, Premature - complications</subject><subject>ORIGINAL ARTICLE</subject><subject>Pregnancy</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotVav3oQexFvqJNlssniSYm2hYEE9h2x2tt2yHzXZFfz3bunizdMc3mfeYR5CbhnMGEj5GCgH0JRBBCpWZ2TMINFUKy3PyRiUkJTFgl2SqxD2AIxr0CMySmKQXLIxedqgL2rb2nK6sK5tfJhuPGaFa4t6O33Hb_Q4XdWtt87buuixJVaN9zu7xWtykdsy4M0wJ-Rz8fIxX9L12-tq_rymjiuuaAwZcpGoyCopkjQVNhHArFARjzJQUuWRddopwdI0krGDGJmSaaK1TgEUigl5OPUefPPVYWhNVQSHZWlrbLpgVP8NMBb14OwEOt-E4DE3B19U1v8YBuZoywRztGUGW_3C3dDcpRVmf_igp8_vh9wGZ8u8V-CK8IdxUCBk0mP0hLW7Ais0-6bzdW_kv7O_Lmx9mA</recordid><startdate>199711</startdate><enddate>199711</enddate><creator>Thorp, James A.</creator><creator>Poskin, Mary F.</creator><creator>McKenzie, David R.</creator><creator>Heimes, Brian</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199711</creationdate><title>Perinatal Factors Predicting Severe Intracranial Hemorrhage</title><author>Thorp, James A. ; Poskin, Mary F. ; McKenzie, David R. ; Heimes, Brian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2727-60de23974a7539bb3a9301a37424d0757f4ac8c731bb456c06e175b9888b007e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cerebral Hemorrhage - blood</topic><topic>Cerebral Hemorrhage - diagnosis</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infant, Premature, Diseases - diagnosis</topic><topic>Infant, Premature, Diseases - etiology</topic><topic>Intensive care medicine</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Obstetric Labor, Premature - blood</topic><topic>Obstetric Labor, Premature - complications</topic><topic>ORIGINAL ARTICLE</topic><topic>Pregnancy</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thorp, James A.</creatorcontrib><creatorcontrib>Poskin, Mary F.</creatorcontrib><creatorcontrib>McKenzie, David R.</creatorcontrib><creatorcontrib>Heimes, Brian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thorp, James A.</au><au>Poskin, Mary F.</au><au>McKenzie, David R.</au><au>Heimes, Brian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perinatal Factors Predicting Severe Intracranial Hemorrhage</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1997-11</date><risdate>1997</risdate><volume>14</volume><issue>10</issue><spage>631</spage><epage>636</epage><pages>631-636</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><coden>AJPEEK</coden><abstract>ABSTRACT
The objective of this paper is to determine the importance of perinatal factors predicting occurrence of severe intracranial hemorrhage (ICH) in premature new-borns. A post-hoc analysis of a previously published randomized, double-blinded, prospective trial was performed. Logistic regression analysis was used to assess the importance of obstetrical variables and umbilical cord blood coagulation studies and acid-base status in predicting severe ICH (grades 3 and 4). The trial lasted 42 months; 401 pregnant women were invited to participate and 48 declined. The most important predictors of severe ICH in order of decreasing significance were: gestational age at delivery (P = 0.0001), duration of painful labor (P = 0.0077), duration of antenatal antibiotic therapy (P = 0.0203), maternal age (P = 0.0247), and factor X activity in umbilical cord blood (P = 0.0302). Mode of delivery, cord blood acid-base, and coagulation status did not correlate with severe ICH. The majority of severe ICHs were late in onset; only two of 31 were known to have occurred in the first 24 hr of life. Gestational age, duration of painful labor, duration of antibiotic therapy, and maternal age were the most important predictors of severe ICH.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>9605251</pmid><doi>10.1055/s-2008-1040767</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cerebral Hemorrhage - blood Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - etiology Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Gestational Age Humans Infant, Newborn Infant, Premature, Diseases - blood Infant, Premature, Diseases - diagnosis Infant, Premature, Diseases - etiology Intensive care medicine Logistic Models Male Maternal Age Medical sciences Obstetric Labor, Premature - blood Obstetric Labor, Premature - complications ORIGINAL ARTICLE Pregnancy Randomized Controlled Trials as Topic Risk Risk Factors Time Factors |
| title | Perinatal Factors Predicting Severe Intracranial Hemorrhage |
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