Immune responses induced by intramuscular or gene gun injection of protective deoxyribonucleic acid vaccines that express the circumsporozoite protein from Plasmodium berghei malaria parasites

The circumsporozoite protein (CSP) is a target for effector Ab and cell mediated immunity against malaria parasites; DNA vaccination can induce both types of effector response. The immunogenicity and efficacy of two DNA plasmids expressing different amounts of Plasmodium berghei CSP were evaluated b...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-12, Vol.159 (12), p.6112-6119
Hauptverfasser:	Leitner, WW, Seguin, MC, Ballou, WR, Seitz, JP, Schultz, AM, Sheehy, MJ, Lyon, JA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - biosynthesis Cattle Epidermis Female Humans Immunization Schedule Immunization, Secondary Immunoglobulin G - biosynthesis Immunoglobulin G - blood Injections, Intradermal Injections, Intramuscular Malaria - immunology Malaria - prevention & control Mice Mice, Inbred BALB C Plasmids - biosynthesis Plasmids - chemical synthesis Plasmids - genetics Plasmodium berghei - genetics Plasmodium berghei - immunology Protozoan Proteins - biosynthesis Protozoan Proteins - genetics Protozoan Proteins - immunology Recombinant Proteins - biosynthesis Sequence Analysis, DNA Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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