Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled?
Activated protein C resistance, most often caused by a single point mutation in the factor V gene, is the most common hereditary coagulation abnormality associated with venous thrombosis. Recent studies have established risk estimates of thrombosis in multiple clinical settings. The impact of activa...
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| Veröffentlicht in: | Annals of medicine (Helsinki) 1997, Vol.29 (6), p.469-472 |
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| container_title | Annals of medicine (Helsinki) |
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| creator | Petäjä, Jari M. Griffin, John H. |
| description | Activated protein C resistance, most often caused by a single point mutation in the factor V gene, is the most common hereditary coagulation abnormality associated with venous thrombosis. Recent studies have established risk estimates of thrombosis in multiple clinical settings. The impact of activated protein C resistance on the absolute thrombotic risk of a given individual is significantly influenced by the presence or absence of other acquired or congenital risk factors. In this paper, the complex interplay between different risk factors for venous thrombosis is discussed. Additionally, the potential significance for arterial thrombosis of activated protein C resistance, that is not due to the genetic variant, Glutamine 506 factor V, is discussed. |
| doi_str_mv | 10.3109/07853899709007469 |
| format | Article |
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Recent studies have established risk estimates of thrombosis in multiple clinical settings. The impact of activated protein C resistance on the absolute thrombotic risk of a given individual is significantly influenced by the presence or absence of other acquired or congenital risk factors. In this paper, the complex interplay between different risk factors for venous thrombosis is discussed. Additionally, the potential significance for arterial thrombosis of activated protein C resistance, that is not due to the genetic variant, Glutamine 506 factor V, is discussed.</description><identifier>ISSN: 0785-3890</identifier><identifier>EISSN: 1365-2060</identifier><identifier>DOI: 10.3109/07853899709007469</identifier><identifier>PMID: 9562511</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>activated protein C resistance ; Adult ; Aged ; Aged, 80 and over ; anticoagulants ; Anticoagulants - pharmacology ; Arginine - genetics ; Biological and medical sciences ; Blood and lymphatic vessels ; blood coagulation disorders ; Blood Coagulation Disorders - genetics ; Cardiology. Vascular system ; Cerebrovascular Disorders - etiology ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Drug Resistance ; factor V ; Factor V - genetics ; Female ; Glutamine - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - etiology ; Point Mutation - genetics ; protein C ; Protein C - genetics ; Protein C - physiology ; Risk Factors ; thrombophilia ; Thrombophlebitis - etiology ; thrombosis ; Thrombosis - etiology</subject><ispartof>Annals of medicine (Helsinki), 1997, Vol.29 (6), p.469-472</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-e5402ad51a8fcc193463aa6ea52ae2439b10db5f88cb2decafadeede12d090483</citedby><cites>FETCH-LOGICAL-c430t-e5402ad51a8fcc193463aa6ea52ae2439b10db5f88cb2decafadeede12d090483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/07853899709007469$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/07853899709007469$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23909,23910,25118,27900,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2183452$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9562511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petäjä, Jari M.</creatorcontrib><creatorcontrib>Griffin, John H.</creatorcontrib><title>Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled?</title><title>Annals of medicine (Helsinki)</title><addtitle>Ann Med</addtitle><description>Activated protein C resistance, most often caused by a single point mutation in the factor V gene, is the most common hereditary coagulation abnormality associated with venous thrombosis. Recent studies have established risk estimates of thrombosis in multiple clinical settings. The impact of activated protein C resistance on the absolute thrombotic risk of a given individual is significantly influenced by the presence or absence of other acquired or congenital risk factors. In this paper, the complex interplay between different risk factors for venous thrombosis is discussed. Additionally, the potential significance for arterial thrombosis of activated protein C resistance, that is not due to the genetic variant, Glutamine 506 factor V, is discussed.</description><subject>activated protein C resistance</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>anticoagulants</subject><subject>Anticoagulants - pharmacology</subject><subject>Arginine - genetics</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>blood coagulation disorders</subject><subject>Blood Coagulation Disorders - genetics</subject><subject>Cardiology. Vascular system</subject><subject>Cerebrovascular Disorders - etiology</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Drug Resistance</subject><subject>factor V</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Glutamine - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - etiology</subject><subject>Point Mutation - genetics</subject><subject>protein C</subject><subject>Protein C - genetics</subject><subject>Protein C - physiology</subject><subject>Risk Factors</subject><subject>thrombophilia</subject><subject>Thrombophlebitis - etiology</subject><subject>thrombosis</subject><subject>Thrombosis - etiology</subject><issn>0785-3890</issn><issn>1365-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSbZpfkAPAR1Kb25HkmVbSaGE7UcCS1qalBzNrDRmHbxWKskJ-ffVsttAKeQ0h_d5h5mHsTcC3isB5gPUjVaNMTUYgLqszB6bCVXpQkIFL9hskxcZgAP2KsZbAJC1gH22b3QltRAzdnVmU3-PiRz_EXyifuRz_pNiHxOOlk74zQoTP8d74jfEF4RhzOilf-DXmyCtiH-e4oaI_IpSGsh9es1edjhEOtrNQ_br65fr-Xmx-P7tYn62KGypIBWkS5DotMCms1YYVVYKsSLUEkmWyiwFuKXumsYupSOLHToiR0K6_G7ZqEP2brv3LvjfE8XUrvtoaRhwJD_FtjbaVFpUGRRb0AYfY6CuvQv9GsNjK6DdiGz_E5k7x7vl03JN7qmxM5fzt7sco8WhC1lXH58wKRpVapmxj1usHzsf1vjgw-DahI-DD3876rkrTv-prwiHtLIYqL31Uxiz3md--AMh_Z88</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Petäjä, Jari M.</creator><creator>Griffin, John H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled?</title><author>Petäjä, Jari M. ; Griffin, John H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-e5402ad51a8fcc193463aa6ea52ae2439b10db5f88cb2decafadeede12d090483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>activated protein C resistance</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>anticoagulants</topic><topic>Anticoagulants - pharmacology</topic><topic>Arginine - genetics</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>blood coagulation disorders</topic><topic>Blood Coagulation Disorders - genetics</topic><topic>Cardiology. Vascular system</topic><topic>Cerebrovascular Disorders - etiology</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Drug Resistance</topic><topic>factor V</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Glutamine - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - etiology</topic><topic>Point Mutation - genetics</topic><topic>protein C</topic><topic>Protein C - genetics</topic><topic>Protein C - physiology</topic><topic>Risk Factors</topic><topic>thrombophilia</topic><topic>Thrombophlebitis - etiology</topic><topic>thrombosis</topic><topic>Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petäjä, Jari M.</creatorcontrib><creatorcontrib>Griffin, John H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of medicine (Helsinki)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petäjä, Jari M.</au><au>Griffin, John H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled?</atitle><jtitle>Annals of medicine (Helsinki)</jtitle><addtitle>Ann Med</addtitle><date>1997</date><risdate>1997</risdate><volume>29</volume><issue>6</issue><spage>469</spage><epage>472</epage><pages>469-472</pages><issn>0785-3890</issn><eissn>1365-2060</eissn><abstract>Activated protein C resistance, most often caused by a single point mutation in the factor V gene, is the most common hereditary coagulation abnormality associated with venous thrombosis. Recent studies have established risk estimates of thrombosis in multiple clinical settings. The impact of activated protein C resistance on the absolute thrombotic risk of a given individual is significantly influenced by the presence or absence of other acquired or congenital risk factors. In this paper, the complex interplay between different risk factors for venous thrombosis is discussed. Additionally, the potential significance for arterial thrombosis of activated protein C resistance, that is not due to the genetic variant, Glutamine 506 factor V, is discussed.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>9562511</pmid><doi>10.3109/07853899709007469</doi><tpages>4</tpages></addata></record> |
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| ispartof | Annals of medicine (Helsinki), 1997, Vol.29 (6), p.469-472 |
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| source | Taylor & Francis:Master (3349 titles); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | activated protein C resistance Adult Aged Aged, 80 and over anticoagulants Anticoagulants - pharmacology Arginine - genetics Biological and medical sciences Blood and lymphatic vessels blood coagulation disorders Blood Coagulation Disorders - genetics Cardiology. Vascular system Cerebrovascular Disorders - etiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug Resistance factor V Factor V - genetics Female Glutamine - genetics Humans Male Medical sciences Middle Aged Myocardial Infarction - etiology Point Mutation - genetics protein C Protein C - genetics Protein C - physiology Risk Factors thrombophilia Thrombophlebitis - etiology thrombosis Thrombosis - etiology |
| title | Activated Protein C Resistance: What Have We Learned Now That the Dust Has Settled? |
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