HLA-DRw52a is involved in alloimmunization against PL-A1 antigen

The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied h...

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Veröffentlicht in:	Human immunology 1990-02, Vol.27 (2), p.73-79
Hauptverfasser:	Valentin, N., Vergracht, A., Bignon, J.D., Cheneau, M.L., Blanchard, D., Kaplan, C., Reznikoff-Etievant, M.F., Muller, J.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Human Platelet Biological and medical sciences Blood Platelets - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Linkage Genetics of the immune response Haplotypes HLA-DR Antigens - genetics HLA-DR Serological Subtypes HLA-DR3 Antigen - genetics Humans Immunization Immunobiology Infant, Newborn Isoantigens - genetics Pregnancy Thrombocytopenia - congenital Thrombocytopenia - genetics Thrombocytopenia - immunology
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