Insulin down-regulates the inducible nitric oxide synthase pathway: nitric oxide as cause and effect of diabetes?

Evidence in this paper indicates that insulin can down-regulate the inducible nitric oxide synthase (iNOS) pathway in vivo. The iNOS pathway is up-regulated in diabetes-prone rats and mice and is associated with an autoimmune process. However, the results presented here indicate that macrophage nitr...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-12, Vol.159 (11), p.5329-5335
Hauptverfasser:	Stevens, RB, Sutherland, DE, Ansite, JD, Saxena, M, Rossini, TJ, Levay-Young, BK, Hering, BJ, Mills, CD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus - etiology Diabetes Mellitus - metabolism Diabetes Mellitus, Experimental - etiology Diabetes Mellitus, Experimental - metabolism Down-Regulation Enzyme Induction Insulin - pharmacology Macrophages - metabolism Nitric Oxide - physiology Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Rats Rats, Inbred BB Transforming Growth Factor beta - metabolism
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