Normal bronchial mucus contains high levels of cancer‐associated antigens, CA125, CA19‐9, and carcinoembryonic antigen
The presence of cancer‐associated antigens CA125, CA19‐9, and carcinoembryonic antigen (CEA) in apparently normal respiratory system was demonstrated histochemically and immunochemically. Epithelial cells lining central airways (trachea, bronchi, and bronchioli) and respiratory glands were specifica...
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| Veröffentlicht in: | Cancer 1990-02, Vol.65 (3), p.506-510 |
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| container_title | Cancer |
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| creator | Matsuoka, Yoichiro Endo, Keigo Kawamura, Yasutaka Yoshida, Toshimichi Saga, Tsuneo Watanabe, Yuji Koizumi, Mitsuru Nakashima, Tetsuo Konishi, Junji Yamaguchi, Nobuo Yatani, Ryuichi |
| description | The presence of cancer‐associated antigens CA125, CA19‐9, and carcinoembryonic antigen (CEA) in apparently normal respiratory system was demonstrated histochemically and immunochemically. Epithelial cells lining central airways (trachea, bronchi, and bronchioli) and respiratory glands were specifically stained by antibodies recognizing CA125, CA19‐9, and CEA. Most, if not all, bronchial mucus obtained from patients without pulmonary diseases during general anesthesia contained remarkably high levels of CA125, CA19‐9, and CEA ranging from 190 to 41,000 U/ml (594–4803 U/mg protein), 210 to 95,000 U/ml (294–197,917 U/mg protein), and 6 to 940 ng/ml (14–209 ng/mg protein), respectively, whereas serum antigen levels were normal in all cases examined. These results suggest that CA125, CA19‐9, and CEA are synthesized and secreted by normal epithelial cells of central airways and/or respiratory glands and that these substances are not specific indicators of abnormal cellular activity. |
| doi_str_mv | 10.1002/1097-0142(19900201)65:3<506::AID-CNCR2820650322>3.0.CO;2-0 |
| format | Article |
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Epithelial cells lining central airways (trachea, bronchi, and bronchioli) and respiratory glands were specifically stained by antibodies recognizing CA125, CA19‐9, and CEA. Most, if not all, bronchial mucus obtained from patients without pulmonary diseases during general anesthesia contained remarkably high levels of CA125, CA19‐9, and CEA ranging from 190 to 41,000 U/ml (594–4803 U/mg protein), 210 to 95,000 U/ml (294–197,917 U/mg protein), and 6 to 940 ng/ml (14–209 ng/mg protein), respectively, whereas serum antigen levels were normal in all cases examined. These results suggest that CA125, CA19‐9, and CEA are synthesized and secreted by normal epithelial cells of central airways and/or respiratory glands and that these substances are not specific indicators of abnormal cellular activity.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19900201)65:3<506::AID-CNCR2820650322>3.0.CO;2-0</identifier><identifier>PMID: 2297641</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antigens, Tumor-Associated, Carbohydrate - analysis ; Bronchi - immunology ; Carcinoembryonic Antigen - analysis ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mucus - immunology ; Reference Values ; Trachea - immunology</subject><ispartof>Cancer, 1990-02, Vol.65 (3), p.506-510</ispartof><rights>Copyright © 1990 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5322-87434dcb21c22b0d2de15546ebe7df884083ebf4b568df028b9dd86a20eafde63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2297641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuoka, Yoichiro</creatorcontrib><creatorcontrib>Endo, Keigo</creatorcontrib><creatorcontrib>Kawamura, Yasutaka</creatorcontrib><creatorcontrib>Yoshida, Toshimichi</creatorcontrib><creatorcontrib>Saga, Tsuneo</creatorcontrib><creatorcontrib>Watanabe, Yuji</creatorcontrib><creatorcontrib>Koizumi, Mitsuru</creatorcontrib><creatorcontrib>Nakashima, Tetsuo</creatorcontrib><creatorcontrib>Konishi, Junji</creatorcontrib><creatorcontrib>Yamaguchi, Nobuo</creatorcontrib><creatorcontrib>Yatani, Ryuichi</creatorcontrib><title>Normal bronchial mucus contains high levels of cancer‐associated antigens, CA125, CA19‐9, and carcinoembryonic antigen</title><title>Cancer</title><addtitle>Cancer</addtitle><description>The presence of cancer‐associated antigens CA125, CA19‐9, and carcinoembryonic antigen (CEA) in apparently normal respiratory system was demonstrated histochemically and immunochemically. Epithelial cells lining central airways (trachea, bronchi, and bronchioli) and respiratory glands were specifically stained by antibodies recognizing CA125, CA19‐9, and CEA. Most, if not all, bronchial mucus obtained from patients without pulmonary diseases during general anesthesia contained remarkably high levels of CA125, CA19‐9, and CEA ranging from 190 to 41,000 U/ml (594–4803 U/mg protein), 210 to 95,000 U/ml (294–197,917 U/mg protein), and 6 to 940 ng/ml (14–209 ng/mg protein), respectively, whereas serum antigen levels were normal in all cases examined. These results suggest that CA125, CA19‐9, and CEA are synthesized and secreted by normal epithelial cells of central airways and/or respiratory glands and that these substances are not specific indicators of abnormal cellular activity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, Tumor-Associated, Carbohydrate - analysis</subject><subject>Bronchi - immunology</subject><subject>Carcinoembryonic Antigen - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucus - immunology</subject><subject>Reference Values</subject><subject>Trachea - immunology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc-KFDEQxoMo67j6CEKfRGF7rCSddPcowtj-W1h2QBTES0gn1TuR7s6aTCvjyUfwGX0SM87sgh4ET5XU91VVUj9CnlOYUwD2mEJd5kAL9pDWdUoAfSTFgj8VIBeL5emLvDlv3rKKgRTAGXvG5zBvVk9YDjfI7Lr4JpkBQJWLgn-4Te7E-CldSyb4ETlirC5lQWfk27kPg-6zNvjRrF06DZOZYmb8uNFujNnaXayzHr9gHzPfZUaPBsPP7z90jN44vUGb6XHjLnCMJ1mzpEz8DnWy1CdJsqkkGDd6HNqw9aMzV_675Fan-4j3DvGYvH_18l3zJj9bvT5tlme5EelzeVUWvLCmZdQw1oJlFqkQhcQWS9tVVQEVx7YrWiEr2wGr2traSmoGqDuLkh-TB_u-l8F_njBu1OCiwb7XI_opqrIWdSF5kYwf90YTfIwBO3UZ3KDDVlFQOzBqt1u12626AqOkUFwlMEolMOpPMEkB1awUU5Ca3z-8YmoHtNetDySSjnv9q-tx-1-T_zn4L4X_AjvjrMU</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>Matsuoka, Yoichiro</creator><creator>Endo, Keigo</creator><creator>Kawamura, Yasutaka</creator><creator>Yoshida, Toshimichi</creator><creator>Saga, Tsuneo</creator><creator>Watanabe, Yuji</creator><creator>Koizumi, Mitsuru</creator><creator>Nakashima, Tetsuo</creator><creator>Konishi, Junji</creator><creator>Yamaguchi, Nobuo</creator><creator>Yatani, Ryuichi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900201</creationdate><title>Normal bronchial mucus contains high levels of cancer‐associated antigens, CA125, CA19‐9, and carcinoembryonic antigen</title><author>Matsuoka, Yoichiro ; Endo, Keigo ; Kawamura, Yasutaka ; Yoshida, Toshimichi ; Saga, Tsuneo ; Watanabe, Yuji ; Koizumi, Mitsuru ; Nakashima, Tetsuo ; Konishi, Junji ; Yamaguchi, Nobuo ; Yatani, Ryuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5322-87434dcb21c22b0d2de15546ebe7df884083ebf4b568df028b9dd86a20eafde63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, Tumor-Associated, Carbohydrate - analysis</topic><topic>Bronchi - immunology</topic><topic>Carcinoembryonic Antigen - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucus - immunology</topic><topic>Reference Values</topic><topic>Trachea - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuoka, Yoichiro</creatorcontrib><creatorcontrib>Endo, Keigo</creatorcontrib><creatorcontrib>Kawamura, Yasutaka</creatorcontrib><creatorcontrib>Yoshida, Toshimichi</creatorcontrib><creatorcontrib>Saga, Tsuneo</creatorcontrib><creatorcontrib>Watanabe, Yuji</creatorcontrib><creatorcontrib>Koizumi, Mitsuru</creatorcontrib><creatorcontrib>Nakashima, Tetsuo</creatorcontrib><creatorcontrib>Konishi, Junji</creatorcontrib><creatorcontrib>Yamaguchi, Nobuo</creatorcontrib><creatorcontrib>Yatani, Ryuichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuoka, Yoichiro</au><au>Endo, Keigo</au><au>Kawamura, Yasutaka</au><au>Yoshida, Toshimichi</au><au>Saga, Tsuneo</au><au>Watanabe, Yuji</au><au>Koizumi, Mitsuru</au><au>Nakashima, Tetsuo</au><au>Konishi, Junji</au><au>Yamaguchi, Nobuo</au><au>Yatani, Ryuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal bronchial mucus contains high levels of cancer‐associated antigens, CA125, CA19‐9, and carcinoembryonic antigen</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>65</volume><issue>3</issue><spage>506</spage><epage>510</epage><pages>506-510</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>The presence of cancer‐associated antigens CA125, CA19‐9, and carcinoembryonic antigen (CEA) in apparently normal respiratory system was demonstrated histochemically and immunochemically. Epithelial cells lining central airways (trachea, bronchi, and bronchioli) and respiratory glands were specifically stained by antibodies recognizing CA125, CA19‐9, and CEA. Most, if not all, bronchial mucus obtained from patients without pulmonary diseases during general anesthesia contained remarkably high levels of CA125, CA19‐9, and CEA ranging from 190 to 41,000 U/ml (594–4803 U/mg protein), 210 to 95,000 U/ml (294–197,917 U/mg protein), and 6 to 940 ng/ml (14–209 ng/mg protein), respectively, whereas serum antigen levels were normal in all cases examined. These results suggest that CA125, CA19‐9, and CEA are synthesized and secreted by normal epithelial cells of central airways and/or respiratory glands and that these substances are not specific indicators of abnormal cellular activity.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2297641</pmid><doi>10.1002/1097-0142(19900201)65:3<506::AID-CNCR2820650322>3.0.CO;2-0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antigens, Tumor-Associated, Carbohydrate - analysis Bronchi - immunology Carcinoembryonic Antigen - analysis Female Humans Immunohistochemistry Male Middle Aged Mucus - immunology Reference Values Trachea - immunology |
| title | Normal bronchial mucus contains high levels of cancer‐associated antigens, CA125, CA19‐9, and carcinoembryonic antigen |
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