Intravenous urography with a new non-ionic contrast media in a clinical phase III study: Iopentol vs iohexol
The safety and diagnostic efficacy of iopentol 300 mg I/ml were compared with iohexol 300 mg I/ml in 300 patients submitted for urography. The study was carried out as a double-blind, randomised parallel study where 149 patients received iopentol and 150 patients iohexol. There were no significant d...
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| Veröffentlicht in: | Clinical radiology 1990, Vol.41 (1), p.37-41 |
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| creator | Rasmussen, F. Dyreborg, U. Larsen, C. Waaler, A. Tove Kristofferson, D. |
| description | The safety and diagnostic efficacy of iopentol 300 mg I/ml were compared with iohexol 300 mg I/ml in 300 patients submitted for urography. The study was carried out as a double-blind, randomised parallel study where 149 patients received iopentol and 150 patients iohexol.
There were no significant differences between the patients receiving the two contrast media with regard to demographic parameters, rate of injection or total dose of injected contrast media.
No changes in blood pressure and no clinically important changes in heart rate were detected in the two groups.
No serious adverse effects occurred. Seven patients (5%) in the iohexol and 12 patients (8%) in the iopentol group experienced adverse effects other than a sensation of warmth. Fourteen iohexol patients (9%) and 18 iopentol patients (12%) experienced warmth related to the contrast injection.
Excellent films were obtained in most patients and no difference in diagnostic quality between iopentol and iohexol was observed. |
| doi_str_mv | 10.1016/S0009-9260(05)80930-4 |
| format | Article |
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There were no significant differences between the patients receiving the two contrast media with regard to demographic parameters, rate of injection or total dose of injected contrast media.
No changes in blood pressure and no clinically important changes in heart rate were detected in the two groups.
No serious adverse effects occurred. Seven patients (5%) in the iohexol and 12 patients (8%) in the iopentol group experienced adverse effects other than a sensation of warmth. Fourteen iohexol patients (9%) and 18 iopentol patients (12%) experienced warmth related to the contrast injection.
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There were no significant differences between the patients receiving the two contrast media with regard to demographic parameters, rate of injection or total dose of injected contrast media.
No changes in blood pressure and no clinically important changes in heart rate were detected in the two groups.
No serious adverse effects occurred. Seven patients (5%) in the iohexol and 12 patients (8%) in the iopentol group experienced adverse effects other than a sensation of warmth. Fourteen iohexol patients (9%) and 18 iopentol patients (12%) experienced warmth related to the contrast injection.
Excellent films were obtained in most patients and no difference in diagnostic quality between iopentol and iohexol was observed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Contrast Media</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodobenzoates</subject><subject>Iohexol</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Triiodobenzoic Acids</subject><subject>Urinary system</subject><subject>Urography</subject><issn>0009-9260</issn><issn>1365-229X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVJcJ20PyGgQwnNYROtvnaVSyghbRcMObSB3ISsna1V1tJG2nXif185Nr72pBHvMzPSg9BFSa5LUsqbX4QQVSgqyVcirmqiGCn4BzQvmRQFper5BM2PyEd0ltLf3ZVTPkMzygmXgsxR3_gxmg34MCU8xfAnmmG1xa9uXGGDPbxiH3zhgncW27Bj04jX0DqDnc-E7V2OTI-HlUmAm6bBaZza7S1uwgB-DD3eJOzCCt5C_wmddqZP8PlwnqOn7w-_738Wi8cfzf23RWFZrcaCVUAr0RkwreS2rlRHJYiaSV63vJSwFLmyzAq-bElXgrHGUgGMc7CG8Zqdo8v93CGGlwnSqNcuWeh74yH_U1dKKFZxmkGxB20MKUXo9BDd2sStLoneWdbvlvVOoSZCv1vWPPddHBZMyyzj2HXQmvMvh9ykLKeLxluXjpisWKmUyNjdHoMsY-Mg6mQdeJv1RrCjboP7z0P-ARV2mgc</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Rasmussen, F.</creator><creator>Dyreborg, U.</creator><creator>Larsen, C.</creator><creator>Waaler, A.</creator><creator>Tove Kristofferson, D.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Intravenous urography with a new non-ionic contrast media in a clinical phase III study: Iopentol vs iohexol</title><author>Rasmussen, F. ; Dyreborg, U. ; Larsen, C. ; Waaler, A. ; Tove Kristofferson, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-37e275faead64c879f26e583648d416eb5648c3c54bd0f1eacac25e344eca3483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Contrast Media</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodobenzoates</topic><topic>Iohexol</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Triiodobenzoic Acids</topic><topic>Urinary system</topic><topic>Urography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasmussen, F.</creatorcontrib><creatorcontrib>Dyreborg, U.</creatorcontrib><creatorcontrib>Larsen, C.</creatorcontrib><creatorcontrib>Waaler, A.</creatorcontrib><creatorcontrib>Tove Kristofferson, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasmussen, F.</au><au>Dyreborg, U.</au><au>Larsen, C.</au><au>Waaler, A.</au><au>Tove Kristofferson, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous urography with a new non-ionic contrast media in a clinical phase III study: Iopentol vs iohexol</atitle><jtitle>Clinical radiology</jtitle><addtitle>Clin Radiol</addtitle><date>1990</date><risdate>1990</risdate><volume>41</volume><issue>1</issue><spage>37</spage><epage>41</epage><pages>37-41</pages><issn>0009-9260</issn><eissn>1365-229X</eissn><coden>CLRAAG</coden><abstract>The safety and diagnostic efficacy of iopentol 300 mg I/ml were compared with iohexol 300 mg I/ml in 300 patients submitted for urography. The study was carried out as a double-blind, randomised parallel study where 149 patients received iopentol and 150 patients iohexol.
There were no significant differences between the patients receiving the two contrast media with regard to demographic parameters, rate of injection or total dose of injected contrast media.
No changes in blood pressure and no clinically important changes in heart rate were detected in the two groups.
No serious adverse effects occurred. Seven patients (5%) in the iohexol and 12 patients (8%) in the iopentol group experienced adverse effects other than a sensation of warmth. Fourteen iohexol patients (9%) and 18 iopentol patients (12%) experienced warmth related to the contrast injection.
Excellent films were obtained in most patients and no difference in diagnostic quality between iopentol and iohexol was observed.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>2404650</pmid><doi>10.1016/S0009-9260(05)80930-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical radiology, 1990, Vol.41 (1), p.37-41 |
| issn | 0009-9260 1365-229X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Biological and medical sciences Contrast Media Double-Blind Method Female Humans Investigative techniques, diagnostic techniques (general aspects) Iodobenzoates Iohexol Male Medical sciences Radiodiagnosis. Nmr imagery. Nmr spectrometry Randomized Controlled Trials as Topic Triiodobenzoic Acids Urinary system Urography |
| title | Intravenous urography with a new non-ionic contrast media in a clinical phase III study: Iopentol vs iohexol |
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