IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent

Tissue macrophages readily produce intracellular pro-IL-1beta in response to stimuli such as LPS, but are limited in mature IL-1beta release compared with blood monocytes. The mechanism of this IL-1beta control may provide important insights into the physiology of IL-1beta at the tissue level. Since...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of immunology (1950) 1997-12, Vol.159 (12), p.5964-5972
Hauptverfasser:	Wewers, MD, Dare, HA, Winnard, AV, Parker, JM, Miller, DK
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Caspase 1 Cysteine Endopeptidases - physiology Cysteine Proteinase Inhibitors - pharmacology Enzyme Activation - immunology Humans Interleukin-1 - metabolism Macrophages, Alveolar - drug effects Macrophages, Alveolar - enzymology Macrophages, Alveolar - metabolism Monocytes - drug effects Monocytes - enzymology Monocytes - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!