Interactions between nitrogen oxide-containing compounds and peripheral benzodiazepine receptors

Nitrogen oxide-containing compounds displaced the peripheral benzodiazepine ligand [ 3H]Ro5-4864 from guinea pig membrane preparations. Sodium nitroprusside (SNP) was the most potent ( IC 50 = 5.61 ± 1.72 × 10 −5 M). Moreover, its ability to bind to these receptors showed marked tissue variability (...

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Veröffentlicht in:	FEBS letters 1990-01, Vol.260 (2), p.169-172
Hauptverfasser:	Weissman, Ben A., Bolger, Gordon T., Chiang, Peter K.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Animals Benzodiazepine receptor, peripheral Benzodiazepinones - metabolism Binding, Competitive Biological and medical sciences Calcium - metabolism Calcium Channels - metabolism Cardiovascular system Cell Membrane - drug effects Cell Membrane - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Ferricyanides - pharmacology Guinea pig heart Guinea Pigs Heart - drug effects Heart Rate - drug effects Kidney - drug effects Kidney - metabolism Medical sciences Miscellaneous Myocardium - metabolism nitrogen oxide Nitroprusside - pharmacology Pharmacology. Drug treatments plasma membranes Rat atrium Rats Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Sodium nitroprusside
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