Cellular effects of hypercholesterolemia in modulation of cancer growth and metastasis: a review of the evidence
Hypercholesterolemia and increased cancer risk have been associated, particularly with the high fat diets characteristic of Western societies. We were interested in the possible association between prexisting hypercholesterolemia and the rapidity and extent of tumor metastases in these patients. To...
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| Veröffentlicht in: | Surgical Oncology 1997-11, Vol.6 (3), p.179-185 |
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| container_title | Surgical Oncology |
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| creator | Mehta, Nikhil Hordines, John Volpe, Carmine Doerr, Ralph Cohen, Stefan A. |
| description | Hypercholesterolemia and increased cancer risk have been associated, particularly with the high fat diets characteristic of Western societies. We were interested in the possible association between prexisting hypercholesterolemia and the rapidity and extent of tumor metastases in these patients. To date there has been only a few studies that have suggested and explored this determinant of cancer metastases although it may play a role in a subset of patients who develop cancers. This article will review the literature on the effects of LDL-cholesterol on cell proliferation and differentiation and speculate on mechanisms of involvement of a hypercholesterolemic milieu on cancer progression and enhancement of metastatic potential. |
| doi_str_mv | 10.1016/S0960-7404(97)00027-3 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0960-7404 |
| ispartof | Surgical Oncology, 1997-11, Vol.6 (3), p.179-185 |
| issn | 0960-7404 1879-3320 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals cancer Cholesterol, LDL - adverse effects Dietary Fats - adverse effects Endothelium, Vascular - physiopathology Female Humans hypercholesterolemia Hypercholesterolemia - complications Hypercholesterolemia - metabolism Hypercholesterolemia - pathology LDL lovastatin Male metastasis Mice Neoplasm Metastasis - physiopathology Neoplasms - etiology Neoplasms - pathology Prognosis |
| title | Cellular effects of hypercholesterolemia in modulation of cancer growth and metastasis: a review of the evidence |
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