Novel nicotinamide adenine dinucleotide analogues as potential anticancer agents: Quest for specific inhibition of inosine monophosphate dehydrogenase

Synthetic nicotinamide adenine dinucleotide (NAD) analogues containing 5-β- d-ribofuranosylnicotinamide (C-NAD), 6-β- d-ribofuranosylpicolinamide (C-PAD), 3-β- d-ribofuranosylbenzamide (BAD), and 2-β- d-ribofuranosylthiazole-4-carboxamide (TAD) in place of the nicotinamide riboside moiety are descri...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 1997-10, Vol.76 (1), p.89-100
1. Verfasser:	Pankiewicz, Krzysztof W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticancer Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Enzyme Inhibitors - classification Enzyme Inhibitors - pharmacology Humans IMP Dehydrogenase - antagonists & inhibitors IMPDH inhibitors NAD - analogs & derivatives NAD - chemical synthesis NAD - therapeutic use NAD analogues Neoplasms - drug therapy Structure-Activity Relationship
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