Echistatin inhibits pp72syk and pp125FAK phosphorylation in fibrinogen-adherent platelets

The adhesion of ADP-stimulated platelets to immobilized fibrinogen induces the tyrosine phosphorylation of multiple proteins which include pp72syk and pp125FAK. The phosphorylation of these two proteins increases as function of time of platelet adhesion to fibrinogen; however, pp72syk results strong...

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Veröffentlicht in:	Biochimie 1997-12, Vol.79 (12), p.769-773
Hauptverfasser:	Staiano, N, Della Morte, R, Di Domenico, C, Tafuri, S, Squillacioti, C, Belisario, M A, Di Natale, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - enzymology Blotting, Western Cell Adhesion Molecules - blood Cell Adhesion Molecules - pharmacology Electrophoresis, Polyacrylamide Gel Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - blood Fibrinogen - metabolism Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Humans Intracellular Signaling Peptides and Proteins Peptides - pharmacology Phosphorylation - drug effects Platelet Adhesiveness - drug effects Platelet Aggregation Inhibitors - pharmacology Precipitin Tests Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - blood Protein-Tyrosine Kinases - pharmacology Syk Kinase
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