Monitoring the effect of triamterene and hydrochlorothiazide on dihydrofolate reductase activity using a new spectrophotometric method

A new spectrophotometric method is developed and applied for the study of the inhibitory effect of triamterene, hydrochlorothiazide and their combinations on the in vitro activity of dihydrofolate reductase enzyme. The method is based on incubating the drug (0.1–1.0 μM) or a buffer control with a so...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1989, Vol.7 (12), p.1551-1557
Hauptverfasser:	Sidhom, Madiha B., Velez, Miriam R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences competitive inhibition of dihydrofolate reductase dihydrofolate reductase Folic Acid Antagonists General pharmacology hydrochlorothiazide Hydrochlorothiazide - pharmacology Indicators and Reagents Kinetics Medical sciences NADP p-dimethylaminocinnamic aldehyde Pharmacology. Drug treatments Spectrophotometry, Ultraviolet Tetrahydrofolate analysis Tetrahydrofolate Dehydrogenase - chemistry Tetrahydrofolates - analysis Tetrahydrofolates - chemistry triamterene Triamterene - pharmacology
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