The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus

The group I specific metabotropic glutamate (mGlu) receptor agonist ( RS)-3,5-dihydroxyphenylglycine (DHPG) (100 μM, 10 min) induced long-term depression (LTD) of synaptic transmission in the CA1 region of adult rat hippocampal slices, measured using a grease-gap recording technique. In “normal” (1...

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Veröffentlicht in:	Neuropharmacology 1997-11, Vol.36 (11), p.1517-1532
Hauptverfasser:	Palmer, M.J., Irving, A.J., Seabrook, G.R., Jane, D.E., Collingridge, G.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	( RS)-2-chloro-5-hydroxyphenylglycine ( RS)-3,5-dihydroxyphenylglycine ( S)-2-amino-4-phosphonobutanoic acid (2S,1′R,2′R,3′R)- 2-(2′,3′-dicarboxycyclopropyl)glycine Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors CHPG DCG-IV Depression, Chemical DHPG Electric Stimulation Electrophysiology Excitatory Amino Acid Agonists - pharmacology Female Fundamental and applied biological sciences. Psychology GABA-A Receptor Agonists Glutamate Glycine - analogs & derivatives Glycine - pharmacology hippocampal Hippocampus - drug effects In Vitro Techniques l-AP4 long-term depression LTD metabotropic glutamate (mGlu) receptor N-methyl- D-aspartate (NMDA) receptor Neuronal Plasticity - drug effects Rats Resorcinols - pharmacology synaptic plasticity Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs
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