Production of sterile transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells

A human neoplastic B cell line SSK41 that expresses IgM on its surface switches spontaneously to IgG-producing cells. The SSK41 line contains a single immunoglobulin heavy-chain locus, the constant region (C) genes of which retain the germline configuration. The IgG-producing SSK41 line was purified...

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Veröffentlicht in:	International immunology 1989, Vol.1 (6), p.631-642
Hauptverfasser:	Sideras, Paschalis, Mizuta, Tatsunobu-Ryushin, Kanamori, Hiroshi, Suzuki, Noboru, Okamoto, Masaya, Kuze, Kogo, Ohno, Hitoshi, Doi, Shoichi, Fukuhara, Shirou, Hassan, Mohammed Sawkat, Hammarström, Lennart, Edvard, Smith, Shimizu, Akira, Honjo, Tasuku
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals B-Lymphocytes - immunology Base Sequence cDNA cloning flow cytometry Genes, Immunoglobulin Genes, Switch Humans Immunoglobulin Constant Regions - genetics Immunoglobulin G - biosynthesis Immunoglobulin gamma-Chains - genetics Immunoglobulin M - biosynthesis Immunoglobulin Switch Region - genetics Iγ regions locus Mice Molecular Sequence Data nucleotide sequences RNA, Messenger - genetics S-S recombination Sequence Homology, Nucleic Acid single CH Transcription, Genetic Tumor Cells, Cultured - immunology
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