Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension
Recent clinical studies suggest that the reflex increase in sympathetic nervous activity accompanying a reduction in blood pressure may contribute to the untoward effects of dihydropyridine calcium antagonists. The aim of this study was to examine whether plasma noradrenaline levels and renin activi...
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| Veröffentlicht in: | European journal of clinical pharmacology 1997, Vol.53 (3-4), p.197-201 |
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| container_title | European journal of clinical pharmacology |
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| creator | SASAGURI, M MATSUMOTO, N NODA, K KOGA, M KINOSHITA, A IDEISHI, M ARAKAWA, K |
| description | Recent clinical studies suggest that the reflex increase in sympathetic nervous activity accompanying a reduction in blood pressure may contribute to the untoward effects of dihydropyridine calcium antagonists. The aim of this study was to examine whether plasma noradrenaline levels and renin activity are increased with the reduction of blood pressure during the initial phase of administration of the long-acting dihydropyridine calcium antagonist amlodipine.
The effects of amlodipine on ambulatory blood pressure and on diurnal variations in plasma noradrenaline and renin activity were examined 1, 4, and 7 days after the start of amlodipine administration in eight inpatients with essential hypertension.
The 24-h mean systolic and diastolic blood pressure on day 7 was significantly lower than it was 1 day before the start of treatment. There was no change in the mean heart rate. The mean trough to peak ratios of systolic and diastolic blood pressure of seven patients were 61% and 71%, respectively. Diurnal patterns of plasma noradrenaline levels and renin activity 1, 4, and 7 days after the start of amlodipine administration were unchanged.
The antihypertensive effects of amlodipine were of slow onset and long duration and were not accompanied by an increase in sympathetic activity or activation of the renin-angiotensin system. |
| doi_str_mv | 10.1007/s002280050362 |
| format | Article |
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The effects of amlodipine on ambulatory blood pressure and on diurnal variations in plasma noradrenaline and renin activity were examined 1, 4, and 7 days after the start of amlodipine administration in eight inpatients with essential hypertension.
The 24-h mean systolic and diastolic blood pressure on day 7 was significantly lower than it was 1 day before the start of treatment. There was no change in the mean heart rate. The mean trough to peak ratios of systolic and diastolic blood pressure of seven patients were 61% and 71%, respectively. Diurnal patterns of plasma noradrenaline levels and renin activity 1, 4, and 7 days after the start of amlodipine administration were unchanged.
The antihypertensive effects of amlodipine were of slow onset and long duration and were not accompanied by an increase in sympathetic activity or activation of the renin-angiotensin system.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s002280050362</identifier><identifier>PMID: 9476031</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Amlodipine - pharmacology ; Amlodipine - therapeutic use ; Antihypertensive agents ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Calcium Channel Blockers - pharmacology ; Cardiovascular system ; Female ; Humans ; Hypertension ; Hypertension - drug therapy ; Hypertension - physiopathology ; Male ; Medical research ; Medical sciences ; Middle Aged ; Norepinephrine - blood ; Pharmacology. Drug treatments ; Renin - blood ; Renin-Angiotensin System - drug effects ; Sympathetic Nervous System - drug effects</subject><ispartof>European journal of clinical pharmacology, 1997, Vol.53 (3-4), p.197-201</ispartof><rights>1998 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-a0a69d10e48cd456b96bfafee4a9100a8e21dd15e1a36e4451298f422a2880323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2105028$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9476031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SASAGURI, M</creatorcontrib><creatorcontrib>MATSUMOTO, N</creatorcontrib><creatorcontrib>NODA, K</creatorcontrib><creatorcontrib>KOGA, M</creatorcontrib><creatorcontrib>KINOSHITA, A</creatorcontrib><creatorcontrib>IDEISHI, M</creatorcontrib><creatorcontrib>ARAKAWA, K</creatorcontrib><title>Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Recent clinical studies suggest that the reflex increase in sympathetic nervous activity accompanying a reduction in blood pressure may contribute to the untoward effects of dihydropyridine calcium antagonists. The aim of this study was to examine whether plasma noradrenaline levels and renin activity are increased with the reduction of blood pressure during the initial phase of administration of the long-acting dihydropyridine calcium antagonist amlodipine.
The effects of amlodipine on ambulatory blood pressure and on diurnal variations in plasma noradrenaline and renin activity were examined 1, 4, and 7 days after the start of amlodipine administration in eight inpatients with essential hypertension.
The 24-h mean systolic and diastolic blood pressure on day 7 was significantly lower than it was 1 day before the start of treatment. There was no change in the mean heart rate. The mean trough to peak ratios of systolic and diastolic blood pressure of seven patients were 61% and 71%, respectively. Diurnal patterns of plasma noradrenaline levels and renin activity 1, 4, and 7 days after the start of amlodipine administration were unchanged.
The antihypertensive effects of amlodipine were of slow onset and long duration and were not accompanied by an increase in sympathetic activity or activation of the renin-angiotensin system.</description><subject>Aged</subject><subject>Amlodipine - pharmacology</subject><subject>Amlodipine - therapeutic use</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cardiovascular system</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norepinephrine - blood</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Renin - blood</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Sympathetic Nervous System - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SASAGURI, M</creatorcontrib><creatorcontrib>MATSUMOTO, N</creatorcontrib><creatorcontrib>NODA, K</creatorcontrib><creatorcontrib>KOGA, M</creatorcontrib><creatorcontrib>KINOSHITA, A</creatorcontrib><creatorcontrib>IDEISHI, M</creatorcontrib><creatorcontrib>ARAKAWA, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SASAGURI, M</au><au>MATSUMOTO, N</au><au>NODA, K</au><au>KOGA, M</au><au>KINOSHITA, A</au><au>IDEISHI, M</au><au>ARAKAWA, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1997</date><risdate>1997</risdate><volume>53</volume><issue>3-4</issue><spage>197</spage><epage>201</epage><pages>197-201</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Recent clinical studies suggest that the reflex increase in sympathetic nervous activity accompanying a reduction in blood pressure may contribute to the untoward effects of dihydropyridine calcium antagonists. The aim of this study was to examine whether plasma noradrenaline levels and renin activity are increased with the reduction of blood pressure during the initial phase of administration of the long-acting dihydropyridine calcium antagonist amlodipine.
The effects of amlodipine on ambulatory blood pressure and on diurnal variations in plasma noradrenaline and renin activity were examined 1, 4, and 7 days after the start of amlodipine administration in eight inpatients with essential hypertension.
The 24-h mean systolic and diastolic blood pressure on day 7 was significantly lower than it was 1 day before the start of treatment. There was no change in the mean heart rate. The mean trough to peak ratios of systolic and diastolic blood pressure of seven patients were 61% and 71%, respectively. Diurnal patterns of plasma noradrenaline levels and renin activity 1, 4, and 7 days after the start of amlodipine administration were unchanged.
The antihypertensive effects of amlodipine were of slow onset and long duration and were not accompanied by an increase in sympathetic activity or activation of the renin-angiotensin system.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>9476031</pmid><doi>10.1007/s002280050362</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1997, Vol.53 (3-4), p.197-201 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| subjects | Aged Amlodipine - pharmacology Amlodipine - therapeutic use Antihypertensive agents Biological and medical sciences Blood pressure Blood Pressure - drug effects Calcium Channel Blockers - pharmacology Cardiovascular system Female Humans Hypertension Hypertension - drug therapy Hypertension - physiopathology Male Medical research Medical sciences Middle Aged Norepinephrine - blood Pharmacology. Drug treatments Renin - blood Renin-Angiotensin System - drug effects Sympathetic Nervous System - drug effects |
| title | Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension |
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