A 361 base pair region of the rat FSH- β promoter contains multiple progesterone receptor-binding sequences and confers progesterone responsiveness

The rat is frequently used as a model to study the role of progesterone (P) in regulating FSH secretion and synthesis. The ability of P to modulate rat FSH- β mRNA levels suggests the presence of a functional hormone response element. We have found three PRE-like sequences upstream of the transcript...

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Veröffentlicht in:	Molecular and cellular endocrinology 1997-12, Vol.136 (1), p.67-78
Hauptverfasser:	O’Conner, James L, Wade, Marlene F, Prendergast, Paul, Edwards, Dean P, Boonyaratanakornkit, Viroj, Mahesh, Virendra B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Cells, Cultured Cloning, Molecular DNA - metabolism Female Follicle Stimulating Hormone - genetics Follicle Stimulating Hormone, beta Subunit FSH Gene expression Gene Expression Regulation - genetics High Mobility Group Proteins - pharmacology Humans Mifepristone - pharmacology Molecular Sequence Data Pituitary Gland, Anterior - cytology Progesterone Progesterone - antagonists & inhibitors Progesterone - pharmacology Progesterone Congeners - pharmacology Progesterone receptor Promegestone - pharmacology Promoter Regions, Genetic - genetics Rats Receptors, Progesterone - metabolism Recombinant Fusion Proteins Steroid response element Transfection
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