Vaccination of dogs against Babesia canis infection
This paper describes the clinico-pathological parameters measured in dogs that were vaccinated against Babesia canis using soluble parasite antigens (SPA) and then challenged. The packed cell volume (PCV) and the plasma creatinine value decreased immediately after challenge. Actual PCV values could...
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| Veröffentlicht in: | Veterinary parasitology 1997-12, Vol.73 (1), p.35-41 |
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| container_title | Veterinary parasitology |
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| creator | Schetters, Th.P.M. Kleuskens, J.A.G.M. Scholtes, N.C. Pasman, J.W. Goovaerts, D. |
| description | This paper describes the clinico-pathological parameters measured in dogs that were vaccinated against
Babesia canis using soluble parasite antigens (SPA) and then challenged. The packed cell volume (PCV) and the plasma creatinine value decreased immediately after challenge. Actual PCV values could be predicted in the first 5–6 days of the infection, assuming that creatinine values were modulated by increase of plasma volume. This association no longer existed after that time, and observations indicated splenic involvement in reduction of numbers of circulating erythrocytes. The anaemia due to
B. canis infection appears to be the result of a multifactorial process including plasma volume increase, erythrocyte retention in the spleen and erythrocyte destruction, partly due to parasite proliferation. Vaccination limited the reduction of PCV values, and the development of splenomegaly. Differences in protection between vaccinated and control animals became apparent 6 days after infection, when a memory immune response becomes operative, and the onset of recovery of vaccinated animals correlated with the onset of antibody production against SPA. |
| doi_str_mv | 10.1016/S0304-4017(97)00044-7 |
| format | Article |
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Babesia canis using soluble parasite antigens (SPA) and then challenged. The packed cell volume (PCV) and the plasma creatinine value decreased immediately after challenge. Actual PCV values could be predicted in the first 5–6 days of the infection, assuming that creatinine values were modulated by increase of plasma volume. This association no longer existed after that time, and observations indicated splenic involvement in reduction of numbers of circulating erythrocytes. The anaemia due to
B. canis infection appears to be the result of a multifactorial process including plasma volume increase, erythrocyte retention in the spleen and erythrocyte destruction, partly due to parasite proliferation. Vaccination limited the reduction of PCV values, and the development of splenomegaly. Differences in protection between vaccinated and control animals became apparent 6 days after infection, when a memory immune response becomes operative, and the onset of recovery of vaccinated animals correlated with the onset of antibody production against SPA.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/S0304-4017(97)00044-7</identifier><identifier>PMID: 9477490</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anaemia ; Anemia - etiology ; Anemia - veterinary ; Animals ; Antigens, Protozoan - immunology ; Babesia - immunology ; Babesia canis ; Babesiosis - blood ; Babesiosis - immunology ; Babesiosis - prevention & control ; Creatinine - blood ; Dog ; Dog Diseases - immunology ; Dog Diseases - parasitology ; Dog Diseases - prevention & control ; Dogs ; Erythrocytes - physiology ; Exoantigen ; Plasma Volume ; Protozoan Vaccines ; Spleen - physiopathology ; Splenomegaly ; Vaccination</subject><ispartof>Veterinary parasitology, 1997-12, Vol.73 (1), p.35-41</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-36e5d8cca8198fd4c5aa19a5900f2403b323ac7a11ed63c3e4e5aeab65d8a4a93</citedby><cites>FETCH-LOGICAL-c391t-36e5d8cca8198fd4c5aa19a5900f2403b323ac7a11ed63c3e4e5aeab65d8a4a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-4017(97)00044-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9477490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schetters, Th.P.M.</creatorcontrib><creatorcontrib>Kleuskens, J.A.G.M.</creatorcontrib><creatorcontrib>Scholtes, N.C.</creatorcontrib><creatorcontrib>Pasman, J.W.</creatorcontrib><creatorcontrib>Goovaerts, D.</creatorcontrib><title>Vaccination of dogs against Babesia canis infection</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>This paper describes the clinico-pathological parameters measured in dogs that were vaccinated against
Babesia canis using soluble parasite antigens (SPA) and then challenged. The packed cell volume (PCV) and the plasma creatinine value decreased immediately after challenge. Actual PCV values could be predicted in the first 5–6 days of the infection, assuming that creatinine values were modulated by increase of plasma volume. This association no longer existed after that time, and observations indicated splenic involvement in reduction of numbers of circulating erythrocytes. The anaemia due to
B. canis infection appears to be the result of a multifactorial process including plasma volume increase, erythrocyte retention in the spleen and erythrocyte destruction, partly due to parasite proliferation. Vaccination limited the reduction of PCV values, and the development of splenomegaly. Differences in protection between vaccinated and control animals became apparent 6 days after infection, when a memory immune response becomes operative, and the onset of recovery of vaccinated animals correlated with the onset of antibody production against SPA.</description><subject>Anaemia</subject><subject>Anemia - etiology</subject><subject>Anemia - veterinary</subject><subject>Animals</subject><subject>Antigens, Protozoan - immunology</subject><subject>Babesia - immunology</subject><subject>Babesia canis</subject><subject>Babesiosis - blood</subject><subject>Babesiosis - immunology</subject><subject>Babesiosis - prevention & control</subject><subject>Creatinine - blood</subject><subject>Dog</subject><subject>Dog Diseases - immunology</subject><subject>Dog Diseases - parasitology</subject><subject>Dog Diseases - prevention & control</subject><subject>Dogs</subject><subject>Erythrocytes - physiology</subject><subject>Exoantigen</subject><subject>Plasma Volume</subject><subject>Protozoan Vaccines</subject><subject>Spleen - physiopathology</subject><subject>Splenomegaly</subject><subject>Vaccination</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq3-hEJOoofobHY3mz2JFr-g4MGP6zLZTMpKm9RsIvjvTdrSa-cyh_d5Z-BhbMrhhgNPb99BgIwlcH1l9DUASBnrIzbmmRZxohQcs_EeOWVnIXwPEKR6xEZGai0NjJn4Qud8ha2vq6guo6JehAgX6KvQRg-YU_AYOax8iHxVkhu4c3ZS4jLQxW5P2OfT48fsJZ6_Pb_O7uexE4a3sUhJFZlzmHGTlYV0CpEbVAagTCSIXCQCnUbOqUiFEyRJIWGe9i2UaMSEXW7vrpv6p6PQ2pUPjpZLrKjugtVGKdPPQZCn0iSKix5UW9A1dQgNlXbd-BU2f5aDHazajVU7KLNG241Vq_vedPegy1dU7Fs7jX1-t82p1_HrqbHBeaocFb7pndmi9gc-_AMD-oXx</recordid><startdate>19971215</startdate><enddate>19971215</enddate><creator>Schetters, Th.P.M.</creator><creator>Kleuskens, J.A.G.M.</creator><creator>Scholtes, N.C.</creator><creator>Pasman, J.W.</creator><creator>Goovaerts, D.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19971215</creationdate><title>Vaccination of dogs against Babesia canis infection</title><author>Schetters, Th.P.M. ; Kleuskens, J.A.G.M. ; Scholtes, N.C. ; Pasman, J.W. ; Goovaerts, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-36e5d8cca8198fd4c5aa19a5900f2403b323ac7a11ed63c3e4e5aeab65d8a4a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anaemia</topic><topic>Anemia - etiology</topic><topic>Anemia - veterinary</topic><topic>Animals</topic><topic>Antigens, Protozoan - immunology</topic><topic>Babesia - immunology</topic><topic>Babesia canis</topic><topic>Babesiosis - blood</topic><topic>Babesiosis - immunology</topic><topic>Babesiosis - prevention & control</topic><topic>Creatinine - blood</topic><topic>Dog</topic><topic>Dog Diseases - immunology</topic><topic>Dog Diseases - parasitology</topic><topic>Dog Diseases - prevention & control</topic><topic>Dogs</topic><topic>Erythrocytes - physiology</topic><topic>Exoantigen</topic><topic>Plasma Volume</topic><topic>Protozoan Vaccines</topic><topic>Spleen - physiopathology</topic><topic>Splenomegaly</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schetters, Th.P.M.</creatorcontrib><creatorcontrib>Kleuskens, J.A.G.M.</creatorcontrib><creatorcontrib>Scholtes, N.C.</creatorcontrib><creatorcontrib>Pasman, J.W.</creatorcontrib><creatorcontrib>Goovaerts, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schetters, Th.P.M.</au><au>Kleuskens, J.A.G.M.</au><au>Scholtes, N.C.</au><au>Pasman, J.W.</au><au>Goovaerts, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination of dogs against Babesia canis infection</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1997-12-15</date><risdate>1997</risdate><volume>73</volume><issue>1</issue><spage>35</spage><epage>41</epage><pages>35-41</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>This paper describes the clinico-pathological parameters measured in dogs that were vaccinated against
Babesia canis using soluble parasite antigens (SPA) and then challenged. The packed cell volume (PCV) and the plasma creatinine value decreased immediately after challenge. Actual PCV values could be predicted in the first 5–6 days of the infection, assuming that creatinine values were modulated by increase of plasma volume. This association no longer existed after that time, and observations indicated splenic involvement in reduction of numbers of circulating erythrocytes. The anaemia due to
B. canis infection appears to be the result of a multifactorial process including plasma volume increase, erythrocyte retention in the spleen and erythrocyte destruction, partly due to parasite proliferation. Vaccination limited the reduction of PCV values, and the development of splenomegaly. Differences in protection between vaccinated and control animals became apparent 6 days after infection, when a memory immune response becomes operative, and the onset of recovery of vaccinated animals correlated with the onset of antibody production against SPA.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9477490</pmid><doi>10.1016/S0304-4017(97)00044-7</doi><tpages>7</tpages></addata></record> |
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| subjects | Anaemia Anemia - etiology Anemia - veterinary Animals Antigens, Protozoan - immunology Babesia - immunology Babesia canis Babesiosis - blood Babesiosis - immunology Babesiosis - prevention & control Creatinine - blood Dog Dog Diseases - immunology Dog Diseases - parasitology Dog Diseases - prevention & control Dogs Erythrocytes - physiology Exoantigen Plasma Volume Protozoan Vaccines Spleen - physiopathology Splenomegaly Vaccination |
| title | Vaccination of dogs against Babesia canis infection |
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