Modulation of the swelling-activated amino acid channel of Leishmania major promastigotes by protein kinases

Leishmania promastigotes respond to hypotonic challenges by a mechanism of regulatory volume decrease (RVD), whereby anionic amino acid channels (HAAC) are hypotonically-activated and intracellular amino acids are released from the cells. Irrespective of the experimental conditions, restoration of i...

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Veröffentlicht in:	Molecular and biochemical parasitology 1997-12, Vol.90 (2), p.449-461
Hauptverfasser:	Vieira, Lita L, Lafuente, Esther, Blum, Joseph, Cabantchik, Z.Ioav
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid channels Amino Acids - metabolism Animals Arachidonic acid Arachidonic Acid - metabolism Arachidonic Acid - pharmacology Calcium - physiology Chloride Channels - physiology Cl − channel Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Fluorescence Hypotonic Solutions Isotonic Solutions Leishmania Leishmania major Leishmania major - growth & development Leishmania major - metabolism Osmolar Concentration Protein kinase A Protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Signal transduction Signal Transduction - physiology Volume regulation
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