Epinephrine potentiates calcium mobilization and activation of protein kinases in platelets stimulated by ADP through a mechanism unrelated to phospholipase C

ADP, added to suspensions of aspirinized 32P-labelled washed platelets, induced reversible platelet aggregation, the rapid elevation of cytosolic Ca 2+ (maximum at 2 s), 20 kDA myosin light chain phosphorylation (maximum faster than 3 s), 40 kDa protein phosphorylation (maximum at 3–10 s) and phosph...

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