Cognitive performance, mood and experimental pain before and during morphine-induced analgesia in patients with chronic non-malignant pain
This paper investigates subjective, behavioral and neurophysiological changes due to treatment with oral sustained-release morphine in six patients with severe non-malignant pain. Patients rated their mood and clinical pain on visual analog scales (VAS). Experimental pain reactions were quantified b...
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| Veröffentlicht in: | Pain (Amsterdam) 1997-12, Vol.73 (3), p.369-375 |
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| creator | Lorenz, Jürgen Beck, Helge Bromm, Burkhart |
| description | This paper investigates subjective, behavioral and neurophysiological changes due to treatment with oral sustained-release morphine in six patients with severe non-malignant pain. Patients rated their mood and clinical pain on visual analog scales (VAS). Experimental pain reactions were quantified by ratings on categorial scales and evoked cerebral potentials (LEP) in response to standardized laser stimuli. A standard auditory oddball task provided reaction time (RT), errors, N1 and P2 of late auditory evoked potentials (AEP), and a P300 component. It was used to measure vigilance and cognitive performance. In parallel with clinical pain reduction, laser pain ratings and LEP amplitudes were significantly reduced. In contrast, auditory P2 and P300 amplitude were found to be even enlarged under morphine. RT and mood also failed to indicate any sedation. It is concluded that LEP indicated the analgesic morphine effects whereas late potentials and P300 from auditory stimuli reflected the perceptual-cognitive status which, instead of being deteriorated by morphine-induced sedation, improved probably due to the removal of pain as a mental stressor. |
| doi_str_mv | 10.1016/S0304-3959(97)00123-1 |
| format | Article |
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Patients rated their mood and clinical pain on visual analog scales (VAS). Experimental pain reactions were quantified by ratings on categorial scales and evoked cerebral potentials (LEP) in response to standardized laser stimuli. A standard auditory oddball task provided reaction time (RT), errors, N1 and P2 of late auditory evoked potentials (AEP), and a P300 component. It was used to measure vigilance and cognitive performance. In parallel with clinical pain reduction, laser pain ratings and LEP amplitudes were significantly reduced. In contrast, auditory P2 and P300 amplitude were found to be even enlarged under morphine. RT and mood also failed to indicate any sedation. It is concluded that LEP indicated the analgesic morphine effects whereas late potentials and P300 from auditory stimuli reflected the perceptual-cognitive status which, instead of being deteriorated by morphine-induced sedation, improved probably due to the removal of pain as a mental stressor.</description><identifier>ISSN: 0304-3959</identifier><identifier>EISSN: 1872-6623</identifier><identifier>DOI: 10.1016/S0304-3959(97)00123-1</identifier><identifier>PMID: 9469527</identifier><identifier>CODEN: PAINDB</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Affect - drug effects ; Analgesics ; Analgesics, Opioid - therapeutic use ; Biological and medical sciences ; Chronic Disease ; Chronic non-malignant pain ; Cognition - drug effects ; Cognitive function ; Event-Related Potentials, P300 - drug effects ; Evoked Potentials, Auditory - drug effects ; Female ; Follow-Up Studies ; Humans ; Laser evoked potentials ; Lasers ; Medical sciences ; Middle Aged ; Morphine ; Morphine - therapeutic use ; Neuropharmacology ; P300 ; Pain - drug therapy ; Pain measurement ; Pain Measurement - methods ; Pharmacology. Drug treatments ; Reaction Time - drug effects ; Time Factors</subject><ispartof>Pain (Amsterdam), 1997-12, Vol.73 (3), p.369-375</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>Lippincott-Raven Publishers.Copyright © Lippincott-Raven Publishers.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5111-9d3a07e8498a443c0b540d1adf3fd1c4c860850f0c86f07d4bde684d7f012d723</citedby><cites>FETCH-LOGICAL-c5111-9d3a07e8498a443c0b540d1adf3fd1c4c860850f0c86f07d4bde684d7f012d723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304395997001231$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2110142$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9469527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenz, Jürgen</creatorcontrib><creatorcontrib>Beck, Helge</creatorcontrib><creatorcontrib>Bromm, Burkhart</creatorcontrib><title>Cognitive performance, mood and experimental pain before and during morphine-induced analgesia in patients with chronic non-malignant pain</title><title>Pain (Amsterdam)</title><addtitle>Pain</addtitle><description>This paper investigates subjective, behavioral and neurophysiological changes due to treatment with oral sustained-release morphine in six patients with severe non-malignant pain. Patients rated their mood and clinical pain on visual analog scales (VAS). Experimental pain reactions were quantified by ratings on categorial scales and evoked cerebral potentials (LEP) in response to standardized laser stimuli. A standard auditory oddball task provided reaction time (RT), errors, N1 and P2 of late auditory evoked potentials (AEP), and a P300 component. It was used to measure vigilance and cognitive performance. In parallel with clinical pain reduction, laser pain ratings and LEP amplitudes were significantly reduced. In contrast, auditory P2 and P300 amplitude were found to be even enlarged under morphine. RT and mood also failed to indicate any sedation. It is concluded that LEP indicated the analgesic morphine effects whereas late potentials and P300 from auditory stimuli reflected the perceptual-cognitive status which, instead of being deteriorated by morphine-induced sedation, improved probably due to the removal of pain as a mental stressor.</description><subject>Adult</subject><subject>Affect - drug effects</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Chronic non-malignant pain</subject><subject>Cognition - drug effects</subject><subject>Cognitive function</subject><subject>Event-Related Potentials, P300 - drug effects</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Laser evoked potentials</subject><subject>Lasers</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine</subject><subject>Morphine - therapeutic use</subject><subject>Neuropharmacology</subject><subject>P300</subject><subject>Pain - drug therapy</subject><subject>Pain measurement</subject><subject>Pain Measurement - methods</subject><subject>Pharmacology. Drug treatments</subject><subject>Reaction Time - drug effects</subject><subject>Time Factors</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O0zAUhSMEGsrAI4zkBUIgEbAdJ45XI1TxJ43EAlhbrn3TGBI72MkUXoGn5qatumVh-eeec6_1naK4YfQNo6x5-5VWVJSVqtVLJV9RynhVsgfFhrWSl03Dq4fF5iJ5XDzJ-QellHOuroorJRpVc7kp_m7jPvjZ3wOZIHUxjSZYeE3GGB0xwRH4je9-hDCbgUzGB7IDlMGx6Jbkwx7Faep9gNIHt1hYjWbYQ_aGoH4ys0d7Jgc_98T2KQZvSYihHM3g98GE-dj4afGoM0OGZ-f9uvj-4f237afy7svHz9t3d6WtGWOlcpWhElqhWiNEZemuFtQx47qqc8wK2za0rWlH8dBR6cTOQdMKJztE5CSvrosXp75Tir8WyLMefbYwDCZAXLKWqq6RTYvC-iS0KeacoNMTkjDpj2ZUrxnoYwZ6BayV1McMNEPfzXnAshvBXVxn6Fh_fq6bbM3QJUTu80XGGfYW6z_FSXaIwwwp_xyWAyTdgxnmHodR2lSqKZlSknG8lbjYOv32ZANkeO_RkS3yx1h8AjtrF_1__v8PveW1DA</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Lorenz, Jürgen</creator><creator>Beck, Helge</creator><creator>Bromm, Burkhart</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Cognitive performance, mood and experimental pain before and during morphine-induced analgesia in patients with chronic non-malignant pain</title><author>Lorenz, Jürgen ; Beck, Helge ; Bromm, Burkhart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5111-9d3a07e8498a443c0b540d1adf3fd1c4c860850f0c86f07d4bde684d7f012d723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Affect - drug effects</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Chronic non-malignant pain</topic><topic>Cognition - drug effects</topic><topic>Cognitive function</topic><topic>Event-Related Potentials, P300 - drug effects</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Laser evoked potentials</topic><topic>Lasers</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morphine</topic><topic>Morphine - therapeutic use</topic><topic>Neuropharmacology</topic><topic>P300</topic><topic>Pain - drug therapy</topic><topic>Pain measurement</topic><topic>Pain Measurement - methods</topic><topic>Pharmacology. Drug treatments</topic><topic>Reaction Time - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenz, Jürgen</creatorcontrib><creatorcontrib>Beck, Helge</creatorcontrib><creatorcontrib>Bromm, Burkhart</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenz, Jürgen</au><au>Beck, Helge</au><au>Bromm, Burkhart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive performance, mood and experimental pain before and during morphine-induced analgesia in patients with chronic non-malignant pain</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>73</volume><issue>3</issue><spage>369</spage><epage>375</epage><pages>369-375</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><coden>PAINDB</coden><abstract>This paper investigates subjective, behavioral and neurophysiological changes due to treatment with oral sustained-release morphine in six patients with severe non-malignant pain. Patients rated their mood and clinical pain on visual analog scales (VAS). Experimental pain reactions were quantified by ratings on categorial scales and evoked cerebral potentials (LEP) in response to standardized laser stimuli. A standard auditory oddball task provided reaction time (RT), errors, N1 and P2 of late auditory evoked potentials (AEP), and a P300 component. It was used to measure vigilance and cognitive performance. In parallel with clinical pain reduction, laser pain ratings and LEP amplitudes were significantly reduced. In contrast, auditory P2 and P300 amplitude were found to be even enlarged under morphine. RT and mood also failed to indicate any sedation. It is concluded that LEP indicated the analgesic morphine effects whereas late potentials and P300 from auditory stimuli reflected the perceptual-cognitive status which, instead of being deteriorated by morphine-induced sedation, improved probably due to the removal of pain as a mental stressor.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9469527</pmid><doi>10.1016/S0304-3959(97)00123-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Affect - drug effects Analgesics Analgesics, Opioid - therapeutic use Biological and medical sciences Chronic Disease Chronic non-malignant pain Cognition - drug effects Cognitive function Event-Related Potentials, P300 - drug effects Evoked Potentials, Auditory - drug effects Female Follow-Up Studies Humans Laser evoked potentials Lasers Medical sciences Middle Aged Morphine Morphine - therapeutic use Neuropharmacology P300 Pain - drug therapy Pain measurement Pain Measurement - methods Pharmacology. Drug treatments Reaction Time - drug effects Time Factors |
| title | Cognitive performance, mood and experimental pain before and during morphine-induced analgesia in patients with chronic non-malignant pain |
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