Effects of extended electrical kindling on exploratory behavior and spatial learning
Short-term electrical kindling, a widely used experimental model of epilepsy, appears to have little effect on behavior. The effects of extended kindling are largely unknown. Rats implanted with kindling electrodes in amygdala (AM) or perforant path (PP) received 300 kindling trials over approximate...
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| Veröffentlicht in: | Behavioural brain research 1997-12, Vol.89 (1), p.179-190 |
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| creator | Cammisuli, Sam Murphy, Michael P Ikeda-Douglas, Candace J Vidya Balkissoon Damian Holsinger, R.M Head, Elizabeth Michalakis Michael Racine, Ron J Milgram, Norton W |
| description | Short-term electrical kindling, a widely used experimental model of epilepsy, appears to have little effect on behavior. The effects of extended kindling are largely unknown. Rats implanted with kindling electrodes in amygdala (AM) or perforant path (PP) received 300 kindling trials over approximately 7 months, and were tested in the Morris watermaze after a 7–10 day recovery period. Kindled animals were impaired during the initial training on hidden-platform acquisition, but not in retention of platform location. No deficits were found in acquiring a new hidden-platform location, latency to reach a visible-platform, or in swim speed. Open-field activity showed a sustained increase when tested during kindling, but only a transient increase when tested following suspension of kindling. Similar results were obtained for both AM and PP kindled animals. Hence, long-term kindling of both of these sites produced behavioral changes that were transient in nature. Further, these results also indicate that propagation of seizure activity from remote sites can alter hippocampally-mediated or related behavior. |
| doi_str_mv | 10.1016/S0166-4328(97)00059-4 |
| format | Article |
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The effects of extended kindling are largely unknown. Rats implanted with kindling electrodes in amygdala (AM) or perforant path (PP) received 300 kindling trials over approximately 7 months, and were tested in the Morris watermaze after a 7–10 day recovery period. Kindled animals were impaired during the initial training on hidden-platform acquisition, but not in retention of platform location. No deficits were found in acquiring a new hidden-platform location, latency to reach a visible-platform, or in swim speed. Open-field activity showed a sustained increase when tested during kindling, but only a transient increase when tested following suspension of kindling. Similar results were obtained for both AM and PP kindled animals. Hence, long-term kindling of both of these sites produced behavioral changes that were transient in nature. Further, these results also indicate that propagation of seizure activity from remote sites can alter hippocampally-mediated or related behavior.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/S0166-4328(97)00059-4</identifier><identifier>PMID: 9475625</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Amygdala ; Animals ; Biological and medical sciences ; Epilepsy ; Exploratory behavior ; Exploratory Behavior - physiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Kindling ; Kindling, Neurologic - physiology ; Male ; Maze Learning - physiology ; Medical sciences ; Memory - physiology ; Motor Activity - physiology ; Nervous system (semeiology, syndromes) ; Neurology ; Perforant path ; Rats ; Spatial learning</subject><ispartof>Behavioural brain research, 1997-12, Vol.89 (1), p.179-190</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-351042f606dbb43ed3cb35267a667eeb39044cc6fab19efeea7d1513ff3a38703</citedby><cites>FETCH-LOGICAL-c420t-351042f606dbb43ed3cb35267a667eeb39044cc6fab19efeea7d1513ff3a38703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-4328(97)00059-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2100258$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9475625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cammisuli, Sam</creatorcontrib><creatorcontrib>Murphy, Michael P</creatorcontrib><creatorcontrib>Ikeda-Douglas, Candace J</creatorcontrib><creatorcontrib>Vidya Balkissoon</creatorcontrib><creatorcontrib>Damian Holsinger, R.M</creatorcontrib><creatorcontrib>Head, Elizabeth</creatorcontrib><creatorcontrib>Michalakis Michael</creatorcontrib><creatorcontrib>Racine, Ron J</creatorcontrib><creatorcontrib>Milgram, Norton W</creatorcontrib><title>Effects of extended electrical kindling on exploratory behavior and spatial learning</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Short-term electrical kindling, a widely used experimental model of epilepsy, appears to have little effect on behavior. The effects of extended kindling are largely unknown. Rats implanted with kindling electrodes in amygdala (AM) or perforant path (PP) received 300 kindling trials over approximately 7 months, and were tested in the Morris watermaze after a 7–10 day recovery period. Kindled animals were impaired during the initial training on hidden-platform acquisition, but not in retention of platform location. No deficits were found in acquiring a new hidden-platform location, latency to reach a visible-platform, or in swim speed. Open-field activity showed a sustained increase when tested during kindling, but only a transient increase when tested following suspension of kindling. Similar results were obtained for both AM and PP kindled animals. Hence, long-term kindling of both of these sites produced behavioral changes that were transient in nature. Further, these results also indicate that propagation of seizure activity from remote sites can alter hippocampally-mediated or related behavior.</description><subject>Amygdala</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Epilepsy</subject><subject>Exploratory behavior</subject><subject>Exploratory Behavior - physiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Kindling</subject><subject>Kindling, Neurologic - physiology</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Medical sciences</subject><subject>Memory - physiology</subject><subject>Motor Activity - physiology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Perforant path</subject><subject>Rats</subject><subject>Spatial learning</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1OGzEURq2KiobQR0CaRYVgMdT_nllVCFFAQuqisLY89jUYJnZqTyJ4-zokypaNr-zv2PfqGKETgi8IJvLn37rIljPanfXqHGMs-pZ_QTPSKdoqwfsDNNsj39BRKS8V4liQQ3TYcyUkFTP0cO092Kk0yTfwNkF04BoY61EO1ozNa4huDPGpSbHmyzFlM6X83gzwbNYh5cZE15SlmUKFRzA5VvgYffVmLPB9V-fo8ff1w9Vte__n5u7q8r61nOKpZYJgTr3E0g0DZ-CYHZigUhkpFcDAesy5tdKbgfTgAYxyRBDmPTOsU5jN0en23WVO_1ZQJr0IxcI4mghpVbTqheCUqU9BIilXuOsqKLagzamUDF4vc1iY_K4J1hvt-kO73jjVvdIf2utujk52DVbDAtz-1s5zzX_sclOqVp9NtKHsMUowpmLT_tcWg2ptHSDrYgNECy7k-iXapfDJIP8BwRCfOA</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Cammisuli, Sam</creator><creator>Murphy, Michael P</creator><creator>Ikeda-Douglas, Candace J</creator><creator>Vidya Balkissoon</creator><creator>Damian Holsinger, R.M</creator><creator>Head, Elizabeth</creator><creator>Michalakis Michael</creator><creator>Racine, Ron J</creator><creator>Milgram, Norton W</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Effects of extended electrical kindling on exploratory behavior and spatial learning</title><author>Cammisuli, Sam ; Murphy, Michael P ; Ikeda-Douglas, Candace J ; Vidya Balkissoon ; Damian Holsinger, R.M ; Head, Elizabeth ; Michalakis Michael ; Racine, Ron J ; Milgram, Norton W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-351042f606dbb43ed3cb35267a667eeb39044cc6fab19efeea7d1513ff3a38703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amygdala</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Epilepsy</topic><topic>Exploratory behavior</topic><topic>Exploratory Behavior - physiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Kindling</topic><topic>Kindling, Neurologic - physiology</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Medical sciences</topic><topic>Memory - physiology</topic><topic>Motor Activity - physiology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Perforant path</topic><topic>Rats</topic><topic>Spatial learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cammisuli, Sam</creatorcontrib><creatorcontrib>Murphy, Michael P</creatorcontrib><creatorcontrib>Ikeda-Douglas, Candace J</creatorcontrib><creatorcontrib>Vidya Balkissoon</creatorcontrib><creatorcontrib>Damian Holsinger, R.M</creatorcontrib><creatorcontrib>Head, Elizabeth</creatorcontrib><creatorcontrib>Michalakis Michael</creatorcontrib><creatorcontrib>Racine, Ron J</creatorcontrib><creatorcontrib>Milgram, Norton W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cammisuli, Sam</au><au>Murphy, Michael P</au><au>Ikeda-Douglas, Candace J</au><au>Vidya Balkissoon</au><au>Damian Holsinger, R.M</au><au>Head, Elizabeth</au><au>Michalakis Michael</au><au>Racine, Ron J</au><au>Milgram, Norton W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of extended electrical kindling on exploratory behavior and spatial learning</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>89</volume><issue>1</issue><spage>179</spage><epage>190</epage><pages>179-190</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Short-term electrical kindling, a widely used experimental model of epilepsy, appears to have little effect on behavior. The effects of extended kindling are largely unknown. Rats implanted with kindling electrodes in amygdala (AM) or perforant path (PP) received 300 kindling trials over approximately 7 months, and were tested in the Morris watermaze after a 7–10 day recovery period. Kindled animals were impaired during the initial training on hidden-platform acquisition, but not in retention of platform location. No deficits were found in acquiring a new hidden-platform location, latency to reach a visible-platform, or in swim speed. Open-field activity showed a sustained increase when tested during kindling, but only a transient increase when tested following suspension of kindling. Similar results were obtained for both AM and PP kindled animals. Hence, long-term kindling of both of these sites produced behavioral changes that were transient in nature. Further, these results also indicate that propagation of seizure activity from remote sites can alter hippocampally-mediated or related behavior.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>9475625</pmid><doi>10.1016/S0166-4328(97)00059-4</doi><tpages>12</tpages></addata></record> |
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| subjects | Amygdala Animals Biological and medical sciences Epilepsy Exploratory behavior Exploratory Behavior - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Kindling Kindling, Neurologic - physiology Male Maze Learning - physiology Medical sciences Memory - physiology Motor Activity - physiology Nervous system (semeiology, syndromes) Neurology Perforant path Rats Spatial learning |
| title | Effects of extended electrical kindling on exploratory behavior and spatial learning |
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