Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling
The objective of this review is to examine the role of neuronal angiotensin II (Ang II) receptors in vitro. Two types of G protein-coupled Ang II receptors have been identified in cardiovascularly relevant areas of the brain: the AT 1 and the AT 2. We have utilized neurons in culture to study the si...
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| Veröffentlicht in: | Regulatory peptides 1997-10, Vol.72 (2), p.139-145 |
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| creator | Gelband, Craig H Sumners, Colin Lu, Di Raizada, Mohan K |
| description | The objective of this review is to examine the role of neuronal angiotensin II (Ang II) receptors in vitro. Two types of G protein-coupled Ang II receptors have been identified in cardiovascularly relevant areas of the brain: the AT
1 and the AT
2. We have utilized neurons in culture to study the signaling mechanisms of AT
1 and AT
2 receptors. Neuronal AT
1 receptors are involved in norepinephrine (NE) neuromodulation. NE neuromodulation can be either
evoked or
enhanced.
Evoked NE neuromodulation involves AT
1 receptor-mediated, losartan-dependent, rapid NE release, inhibition of K
+ channels and stimulation of Ca
2+ channels. AT
1 receptor-mediated
enhanced NE neuromodulation involves the Ras-Raf-MAP kinase cascade and ultimately leads to an increase in NE transporter, tyrosine hydroxylase and dopamine β-hydroxylase mRNA transcription. Neuronal AT
2 receptors signal via a G
i protein and are coupled to activation of PP2A and PLA
2 and stimulation of K
+ channels. Finally, putative cross-talk pathways between AT
1 and AT
2 receptors will be discussed. |
| doi_str_mv | 10.1016/S0167-0115(97)01050-1 |
| format | Article |
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1 and the AT
2. We have utilized neurons in culture to study the signaling mechanisms of AT
1 and AT
2 receptors. Neuronal AT
1 receptors are involved in norepinephrine (NE) neuromodulation. NE neuromodulation can be either
evoked or
enhanced.
Evoked NE neuromodulation involves AT
1 receptor-mediated, losartan-dependent, rapid NE release, inhibition of K
+ channels and stimulation of Ca
2+ channels. AT
1 receptor-mediated
enhanced NE neuromodulation involves the Ras-Raf-MAP kinase cascade and ultimately leads to an increase in NE transporter, tyrosine hydroxylase and dopamine β-hydroxylase mRNA transcription. Neuronal AT
2 receptors signal via a G
i protein and are coupled to activation of PP2A and PLA
2 and stimulation of K
+ channels. Finally, putative cross-talk pathways between AT
1 and AT
2 receptors will be discussed.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/S0167-0115(97)01050-1</identifier><identifier>PMID: 9652973</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; AT 1 receptor ; AT 2 receptor ; Biological and medical sciences ; Brain - cytology ; Brain - drug effects ; Brain - enzymology ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Coculture Techniques ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Enzymologic - drug effects ; Gene Expression Regulation, Enzymologic - genetics ; Humans ; K + channels ; MAP kinase ; Mixed Function Oxygenases - genetics ; Mixed Function Oxygenases - metabolism ; Neuromodulation ; Neurons ; Neurons - drug effects ; Neurons - metabolism ; Norepinephrine - metabolism ; Norepinephrine - pharmacology ; Receptor, Angiotensin, Type 1 ; Receptor, Angiotensin, Type 2 ; Receptors, Angiotensin - drug effects ; Receptors, Angiotensin - genetics ; Receptors, Angiotensin - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal transduction ; Signal Transduction - drug effects ; Signal Transduction - genetics ; Sympathomimetics - metabolism ; Sympathomimetics - pharmacology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Regulatory peptides, 1997-10, Vol.72 (2), p.139-145</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-f58144b0091d1e6694145a244ff775e240fd42f3e0a8c2c243661304e0119dc63</citedby><cites>FETCH-LOGICAL-c389t-f58144b0091d1e6694145a244ff775e240fd42f3e0a8c2c243661304e0119dc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-0115(97)01050-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2109514$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9652973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gelband, Craig H</creatorcontrib><creatorcontrib>Sumners, Colin</creatorcontrib><creatorcontrib>Lu, Di</creatorcontrib><creatorcontrib>Raizada, Mohan K</creatorcontrib><title>Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>The objective of this review is to examine the role of neuronal angiotensin II (Ang II) receptors in vitro. Two types of G protein-coupled Ang II receptors have been identified in cardiovascularly relevant areas of the brain: the AT
1 and the AT
2. We have utilized neurons in culture to study the signaling mechanisms of AT
1 and AT
2 receptors. Neuronal AT
1 receptors are involved in norepinephrine (NE) neuromodulation. NE neuromodulation can be either
evoked or
enhanced.
Evoked NE neuromodulation involves AT
1 receptor-mediated, losartan-dependent, rapid NE release, inhibition of K
+ channels and stimulation of Ca
2+ channels. AT
1 receptor-mediated
enhanced NE neuromodulation involves the Ras-Raf-MAP kinase cascade and ultimately leads to an increase in NE transporter, tyrosine hydroxylase and dopamine β-hydroxylase mRNA transcription. Neuronal AT
2 receptors signal via a G
i protein and are coupled to activation of PP2A and PLA
2 and stimulation of K
+ channels. Finally, putative cross-talk pathways between AT
1 and AT
2 receptors will be discussed.</description><subject>Animals</subject><subject>AT 1 receptor</subject><subject>AT 2 receptor</subject><subject>Biological and medical sciences</subject><subject>Brain - cytology</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Coculture Techniques</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Enzymologic - drug effects</subject><subject>Gene Expression Regulation, Enzymologic - genetics</subject><subject>Humans</subject><subject>K + channels</subject><subject>MAP kinase</subject><subject>Mixed Function Oxygenases - genetics</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Neuromodulation</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Norepinephrine - pharmacology</subject><subject>Receptor, Angiotensin, Type 1</subject><subject>Receptor, Angiotensin, Type 2</subject><subject>Receptors, Angiotensin - drug effects</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Receptors, Angiotensin - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - genetics</subject><subject>Sympathomimetics - metabolism</subject><subject>Sympathomimetics - pharmacology</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoSbeb_ISAD6WkB7ca68vqpYTQLwj00OYYhCKPEhVbciW70H8fbXbZay8zDO87Xw8hF0DfAwX54WcNqqUA4lKrdxSooC2ckA30irUge_mCbI6WV-R1Kb8pBaEUOyWnWopOK7Yhd1fxIaQFYwmxyehwXlIujY1DE1PGOUScH3ONTcQ1pykN62iXkOLHJkzzGNxzUZrkG79Gtyvs2Li0Vi0-nJGX3o4Fzw95S26_fP51_a29-fH1-_XVTetYr5fWix44v6dUwwAopebAhe04914pgR2nfuCdZ0ht7zrXcSYlMMqxvqYHJ9mWvN3PnXP6s2JZzBSKw3G0EdNajNJCMFlf3xKxN7qcSsnozZzDZPM_A9TssJpnrGbHzOhdrlgN1L6Lw4L1fsLh2HXgWPU3B90WZ0efbXShHG0dUC2AV9unvQ0rjL8BsykuYHQ4hMp-MUMK_znkCfrilNo</recordid><startdate>19971031</startdate><enddate>19971031</enddate><creator>Gelband, Craig H</creator><creator>Sumners, Colin</creator><creator>Lu, Di</creator><creator>Raizada, Mohan K</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971031</creationdate><title>Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling</title><author>Gelband, Craig H ; Sumners, Colin ; Lu, Di ; Raizada, Mohan K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-f58144b0091d1e6694145a244ff775e240fd42f3e0a8c2c243661304e0119dc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>AT 1 receptor</topic><topic>AT 2 receptor</topic><topic>Biological and medical sciences</topic><topic>Brain - cytology</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Coculture Techniques</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Enzymologic - drug effects</topic><topic>Gene Expression Regulation, Enzymologic - genetics</topic><topic>Humans</topic><topic>K + channels</topic><topic>MAP kinase</topic><topic>Mixed Function Oxygenases - genetics</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Neuromodulation</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Norepinephrine - metabolism</topic><topic>Norepinephrine - pharmacology</topic><topic>Receptor, Angiotensin, Type 1</topic><topic>Receptor, Angiotensin, Type 2</topic><topic>Receptors, Angiotensin - drug effects</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Receptors, Angiotensin - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - genetics</topic><topic>Sympathomimetics - metabolism</topic><topic>Sympathomimetics - pharmacology</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gelband, Craig H</creatorcontrib><creatorcontrib>Sumners, Colin</creatorcontrib><creatorcontrib>Lu, Di</creatorcontrib><creatorcontrib>Raizada, Mohan K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gelband, Craig H</au><au>Sumners, Colin</au><au>Lu, Di</au><au>Raizada, Mohan K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1997-10-31</date><risdate>1997</risdate><volume>72</volume><issue>2</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>The objective of this review is to examine the role of neuronal angiotensin II (Ang II) receptors in vitro. Two types of G protein-coupled Ang II receptors have been identified in cardiovascularly relevant areas of the brain: the AT
1 and the AT
2. We have utilized neurons in culture to study the signaling mechanisms of AT
1 and AT
2 receptors. Neuronal AT
1 receptors are involved in norepinephrine (NE) neuromodulation. NE neuromodulation can be either
evoked or
enhanced.
Evoked NE neuromodulation involves AT
1 receptor-mediated, losartan-dependent, rapid NE release, inhibition of K
+ channels and stimulation of Ca
2+ channels. AT
1 receptor-mediated
enhanced NE neuromodulation involves the Ras-Raf-MAP kinase cascade and ultimately leads to an increase in NE transporter, tyrosine hydroxylase and dopamine β-hydroxylase mRNA transcription. Neuronal AT
2 receptors signal via a G
i protein and are coupled to activation of PP2A and PLA
2 and stimulation of K
+ channels. Finally, putative cross-talk pathways between AT
1 and AT
2 receptors will be discussed.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9652973</pmid><doi>10.1016/S0167-0115(97)01050-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Regulatory peptides, 1997-10, Vol.72 (2), p.139-145 |
| issn | 0167-0115 1873-1686 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals AT 1 receptor AT 2 receptor Biological and medical sciences Brain - cytology Brain - drug effects Brain - enzymology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Coculture Techniques Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Humans K + channels MAP kinase Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Neuromodulation Neurons Neurons - drug effects Neurons - metabolism Norepinephrine - metabolism Norepinephrine - pharmacology Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin - drug effects Receptors, Angiotensin - genetics Receptors, Angiotensin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Sympathomimetics - metabolism Sympathomimetics - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs |
| title | Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling |
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