In-vitro selection of HIV-1 variants resistant to non-nucleoside reverse transcriptase inhibitors in monocyte-derived macrophages

Unlike the selection of HIV-1 variants resistant to anti-retroviral drugs in human peripheral blood mononuclear cells and T cell lines, induction of resistance in monocyte-derived macrophages has not been widely studied. Since macrophages serve as a potential HIV-1 reservoir in humans, knowledge of...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1997-12, Vol.40 (6), p.847-853
Hauptverfasser:	BEEN-TIKTAK, A. M. M, DE HAAS, C. J. C, DE GRAAF, L, BOUCHER, C. A. B, VERHOEF, J, BORLEFFS, J. C. C, NOTTET, H. S. L. M, SCHUURMAN, R
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Delavirdine - pharmacology Drug Resistance, Microbial - genetics HIV Reverse Transcriptase - chemistry HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - genetics Humans Macrophages - virology Medical sciences Molecular Sequence Data Monocytes Pharmacology. Drug treatments Piperazines - pharmacology Reverse Transcriptase Inhibitors - pharmacology Sequence Homology, Amino Acid Zidovudine - pharmacology
Online-Zugang:	Volltext
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