IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (FcεRII)

CD23, the low‐affinity IgE receptor, is up‐regulated on interleukin (IL)‐4‐stimulated B cells and monocytes, with a concomitant increase in the release of soluble fragments of CD23 (sCD23) into the medium by proteolytic processing of the surface‐bound intact CD23. The effect of inhibition of the pro...

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Veröffentlicht in:	European journal of immunology 1997-12, Vol.27 (12), p.3228-3235
Hauptverfasser:	Christie, Gary, Barton, Aisling, Bolognese, Brian, Buckle, Derek R., Cook, Richard M., Hansbury, Michael J., Harper, Gregory P., Marshall, Lisa A., McCord, Mark E., Moulder, Kevin, Murdock, Paul R., Seal, Sheila M., Spackman, Vivienne M., Weston, Beverley J., Mayer, Ruth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology Batimastat CD23 Cell Line, Transformed Humans IgE Metalloprotease Mice Monocytes - immunology Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Protease Inhibitors - pharmacology Receptors, IgE - immunology Signal Transduction - drug effects Signal Transduction - immunology Thiophenes - pharmacology
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