Serotonin Metabolism in Chronic Tension-Type Headache
Serotonergic neurons play a major role in the regulation of pain and may therefore also be involved in the pathophysiology of tension-type headache. Platelets are important in the regulation of the free serotonin level in plasma and may be a model of serotonergic neurons. The aim of the present stud...
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| Veröffentlicht in: | Cephalalgia 1997-12, Vol.17 (8), p.843-848 |
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| creator | Bendtsen, L Jensen, R Hindberg, I Gammeltoft, S Olesen, J |
| description | Serotonergic neurons play a major role in the regulation of pain and may therefore also be involved in the pathophysiology of tension-type headache. Platelets are important in the regulation of the free serotonin level in plasma and may be a model of serotonergic neurons. The aim of the present study was to investigate the peripheral serotonin (5HT) metabolism in patients with chronic tension-type headache. The 5HT levels in platelets and in plasma, the beta-thromboglobulin (ß-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls. The platelet uptake index was calculated as the ratio between platelet 5HT and plasma 5HT levels. There were, no significant differences in platelet 5HT, plasma 5HT ß-TG, or 5HIAA between patients and controls. The platelet uptake index was significantly lower in patients 243 (136-367) than in controls 352 (202-508), p=0.03. Our results indicate that the peripheral 5HT metabolism is largely normal in patients with chronic tension-type headache. |
| doi_str_mv | 10.1046/j.1468-2982.1997.1708843.x |
| format | Article |
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Platelets are important in the regulation of the free serotonin level in plasma and may be a model of serotonergic neurons. The aim of the present study was to investigate the peripheral serotonin (5HT) metabolism in patients with chronic tension-type headache. The 5HT levels in platelets and in plasma, the beta-thromboglobulin (ß-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls. The platelet uptake index was calculated as the ratio between platelet 5HT and plasma 5HT levels. There were, no significant differences in platelet 5HT, plasma 5HT ß-TG, or 5HIAA between patients and controls. The platelet uptake index was significantly lower in patients 243 (136-367) than in controls 352 (202-508), p=0.03. Our results indicate that the peripheral 5HT metabolism is largely normal in patients with chronic tension-type headache.</description><identifier>ISSN: 0333-1024</identifier><identifier>EISSN: 1468-2982</identifier><identifier>DOI: 10.1046/j.1468-2982.1997.1708843.x</identifier><identifier>PMID: 9453272</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Analgesics - therapeutic use ; beta-Thromboglobulin - metabolism ; Blood Platelets - metabolism ; Central sensitization ; Chronic Disease ; Female ; Humans ; Hydroxyindoleacetic Acid - urine ; Male ; Middle Aged ; pain ; serotonin ; Serotonin - blood ; Tension-Type Headache - blood ; Tension-Type Headache - drug therapy ; Tension-Type Headache - metabolism ; tension‐type headache</subject><ispartof>Cephalalgia, 1997-12, Vol.17 (8), p.843-848</ispartof><rights>1997 International Headache Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4883-3a86ac3ca92a4a7e79e306d7a0425fd7fa1c02a3dff1779a7fcab01f812debd83</citedby><cites>FETCH-LOGICAL-c4883-3a86ac3ca92a4a7e79e306d7a0425fd7fa1c02a3dff1779a7fcab01f812debd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.1997.1708843.x$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1046/j.1468-2982.1997.1708843.x$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1417,21819,27924,27925,43621,43622,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9453272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bendtsen, L</creatorcontrib><creatorcontrib>Jensen, R</creatorcontrib><creatorcontrib>Hindberg, I</creatorcontrib><creatorcontrib>Gammeltoft, S</creatorcontrib><creatorcontrib>Olesen, J</creatorcontrib><title>Serotonin Metabolism in Chronic Tension-Type Headache</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>Serotonergic neurons play a major role in the regulation of pain and may therefore also be involved in the pathophysiology of tension-type headache. Platelets are important in the regulation of the free serotonin level in plasma and may be a model of serotonergic neurons. The aim of the present study was to investigate the peripheral serotonin (5HT) metabolism in patients with chronic tension-type headache. The 5HT levels in platelets and in plasma, the beta-thromboglobulin (ß-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls. The platelet uptake index was calculated as the ratio between platelet 5HT and plasma 5HT levels. There were, no significant differences in platelet 5HT, plasma 5HT ß-TG, or 5HIAA between patients and controls. The platelet uptake index was significantly lower in patients 243 (136-367) than in controls 352 (202-508), p=0.03. Our results indicate that the peripheral 5HT metabolism is largely normal in patients with chronic tension-type headache.</description><subject>Adult</subject><subject>Analgesics - therapeutic use</subject><subject>beta-Thromboglobulin - metabolism</subject><subject>Blood Platelets - metabolism</subject><subject>Central sensitization</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pain</subject><subject>serotonin</subject><subject>Serotonin - blood</subject><subject>Tension-Type Headache - blood</subject><subject>Tension-Type Headache - drug therapy</subject><subject>Tension-Type Headache - metabolism</subject><subject>tension‐type headache</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9Lw0AQxRdRaq1-BKF48Ja4_5Ld9SahWqGiYD0vk83EpqRJzTbYfnsTGjzraXjzZt4MP0JuGA0ZlfHdOmQy1gE3mofMGBUyRbWWItyfkPGvdUrGVAgRMMrlObnwfk0pjWIaj8jIyEhwxcckesem3tVVUU1fcAdpXRZ-M-1Usmq6rpsusfJFXQXLwxanc4QM3AovyVkOpceroU7Ix-NsmcyDxevTc_KwCJzUWgQCdAxOODAcJChUBgWNMwVU8ijPVA7MUQ4iy3OmlAGVO0gpyzXjGaaZFhNye8zdNvVXi35nN4V3WJZQYd16q0wkpTK8G7w_Drqm9r7B3G6bYgPNwTJqe2Z2bXswtgdje2Z2YGb33fL1cKVNN5j9rg6QOj85-t9FiYd_JNtk9jYfVJeijikePtGu67apOnR_-e8HCV6MnA</recordid><startdate>199712</startdate><enddate>199712</enddate><creator>Bendtsen, L</creator><creator>Jensen, R</creator><creator>Hindberg, I</creator><creator>Gammeltoft, S</creator><creator>Olesen, J</creator><general>SAGE Publications</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199712</creationdate><title>Serotonin Metabolism in Chronic Tension-Type Headache</title><author>Bendtsen, L ; Jensen, R ; Hindberg, I ; Gammeltoft, S ; Olesen, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4883-3a86ac3ca92a4a7e79e306d7a0425fd7fa1c02a3dff1779a7fcab01f812debd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Analgesics - therapeutic use</topic><topic>beta-Thromboglobulin - metabolism</topic><topic>Blood Platelets - metabolism</topic><topic>Central sensitization</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - urine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pain</topic><topic>serotonin</topic><topic>Serotonin - blood</topic><topic>Tension-Type Headache - blood</topic><topic>Tension-Type Headache - drug therapy</topic><topic>Tension-Type Headache - metabolism</topic><topic>tension‐type headache</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bendtsen, L</creatorcontrib><creatorcontrib>Jensen, R</creatorcontrib><creatorcontrib>Hindberg, I</creatorcontrib><creatorcontrib>Gammeltoft, S</creatorcontrib><creatorcontrib>Olesen, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bendtsen, L</au><au>Jensen, R</au><au>Hindberg, I</au><au>Gammeltoft, S</au><au>Olesen, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin Metabolism in Chronic Tension-Type Headache</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>1997-12</date><risdate>1997</risdate><volume>17</volume><issue>8</issue><spage>843</spage><epage>848</epage><pages>843-848</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Serotonergic neurons play a major role in the regulation of pain and may therefore also be involved in the pathophysiology of tension-type headache. Platelets are important in the regulation of the free serotonin level in plasma and may be a model of serotonergic neurons. The aim of the present study was to investigate the peripheral serotonin (5HT) metabolism in patients with chronic tension-type headache. The 5HT levels in platelets and in plasma, the beta-thromboglobulin (ß-TG) levels in plasma, and the urinary excretion of 5-hydroxyindoleacetic acid (5HIAA) were measured in 40 patients with chronic tension-type headache and in 40 healthy controls. The platelet uptake index was calculated as the ratio between platelet 5HT and plasma 5HT levels. There were, no significant differences in platelet 5HT, plasma 5HT ß-TG, or 5HIAA between patients and controls. The platelet uptake index was significantly lower in patients 243 (136-367) than in controls 352 (202-508), p=0.03. Our results indicate that the peripheral 5HT metabolism is largely normal in patients with chronic tension-type headache.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>9453272</pmid><doi>10.1046/j.1468-2982.1997.1708843.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cephalalgia, 1997-12, Vol.17 (8), p.843-848 |
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| source | MEDLINE; SAGE Complete A-Z List; Wiley Online Library All Journals |
| subjects | Adult Analgesics - therapeutic use beta-Thromboglobulin - metabolism Blood Platelets - metabolism Central sensitization Chronic Disease Female Humans Hydroxyindoleacetic Acid - urine Male Middle Aged pain serotonin Serotonin - blood Tension-Type Headache - blood Tension-Type Headache - drug therapy Tension-Type Headache - metabolism tension‐type headache |
| title | Serotonin Metabolism in Chronic Tension-Type Headache |
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