Spontaneous myelofibrosis in castrated and ovariectomized NMRI mice
The histopathological appearance of myelofibrosis of the bone marrow is described in aged castrated males, ovariectomized females and in male and female control NMRI mice. The highest incidence of the lesion was observed in ovariectomized and female control mice where more than 90% of the animals we...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1997-12, Vol.49 (5), p.351-353 |
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| container_end_page | 353 |
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| container_issue | 5 |
| container_start_page | 351 |
| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
| container_volume | 49 |
| creator | Rittinghausen, S. Kohler, M. Kamino, K. Dasenbrock, C. Mohr, U. |
| description | The histopathological appearance of myelofibrosis of the bone marrow is described in aged castrated males, ovariectomized females and in male and female control NMRI mice. The highest incidence of the lesion was observed in ovariectomized and female control mice where more than 90% of the animals were affected. The presence of myelofibrosis in the bone marrow of ovariectomized females and castrated males indicates that estrogens may not play a major role in the development of the lesion and other hormonal disturbances must also be considered. |
| doi_str_mv | 10.1016/S0940-2993(97)80109-1 |
| format | Article |
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The highest incidence of the lesion was observed in ovariectomized and female control mice where more than 90% of the animals were affected. The presence of myelofibrosis in the bone marrow of ovariectomized females and castrated males indicates that estrogens may not play a major role in the development of the lesion and other hormonal disturbances must also be considered.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/S0940-2993(97)80109-1</identifier><identifier>PMID: 9455681</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Age Factors ; Animals ; Biological and medical sciences ; Bone Marrow - pathology ; Bone marrow, myelofibrosis ; Castration - veterinary ; Female ; Gonadal hormones, myelofibrosis ; Hematologic and hematopoietic diseases ; Incidence ; Male ; Medical sciences ; Mice ; Mice, Inbred Strains ; Myelofibrosis ; Other diseases. 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The highest incidence of the lesion was observed in ovariectomized and female control mice where more than 90% of the animals were affected. The presence of myelofibrosis in the bone marrow of ovariectomized females and castrated males indicates that estrogens may not play a major role in the development of the lesion and other hormonal disturbances must also be considered.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Bone marrow, myelofibrosis</subject><subject>Castration - veterinary</subject><subject>Female</subject><subject>Gonadal hormones, myelofibrosis</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Myelofibrosis</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Ovariectomy - veterinary</subject><subject>Primary Myelofibrosis - epidemiology</subject><subject>Primary Myelofibrosis - pathology</subject><subject>Primary Myelofibrosis - veterinary</subject><subject>Rodent Diseases - epidemiology</subject><subject>Rodent Diseases - pathology</subject><subject>Sex Factors</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElLAzEUgIMotVZ_QmEOInoYfZlsk5NIcSlUBavnkMlkIDJLTaaF-utNF3r19OC9720fQmMMtxgwv5uDpJBmUpJrKW5ywCBTfISGmOM8xZSQYzQ8IKfoLIRvgAwkwwM0kJQxnuMhmswXXdvr1nbLkDRrW3eVK3wXXEhcmxgdeq97Wya6LZNupb2zpu8a9xtTb68f06Rxxp6jk0rXwV7s4wh9PT1-Tl7S2fvzdPIwSw0hok8Z5SSjlaYZFsaWBVBqhKUCmGaFkJkocwvESMLzrNSMgZBQ5DwnOfDKaExG6Go3d-G7n6UNvWpcMLaud-crIRmlnEME2Q408ZPgbaUW3jXarxUGtZGntvLUxoySQm3lqc2C8X7Bsmhseeja24r1y31dB6PryuvWuHDAsjgFSx6x-x1mo4yVs14F42wbf3Y-6lNl5_455A8YLopF</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Rittinghausen, S.</creator><creator>Kohler, M.</creator><creator>Kamino, K.</creator><creator>Dasenbrock, C.</creator><creator>Mohr, U.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Spontaneous myelofibrosis in castrated and ovariectomized NMRI mice</title><author>Rittinghausen, S. ; Kohler, M. ; Kamino, K. ; Dasenbrock, C. ; Mohr, U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-546324fa4217cedb044c7e4705a5b7927d8e03c93682da550790b8683806fca13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Bone marrow, myelofibrosis</topic><topic>Castration - veterinary</topic><topic>Female</topic><topic>Gonadal hormones, myelofibrosis</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Myelofibrosis</topic><topic>Other diseases. 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| identifier | ISSN: 0940-2993 |
| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 1997-12, Vol.49 (5), p.351-353 |
| issn | 0940-2993 1618-1433 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79544660 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Age Factors Animals Biological and medical sciences Bone Marrow - pathology Bone marrow, myelofibrosis Castration - veterinary Female Gonadal hormones, myelofibrosis Hematologic and hematopoietic diseases Incidence Male Medical sciences Mice Mice, Inbred Strains Myelofibrosis Other diseases. Hematologic involvement in other diseases Ovariectomy - veterinary Primary Myelofibrosis - epidemiology Primary Myelofibrosis - pathology Primary Myelofibrosis - veterinary Rodent Diseases - epidemiology Rodent Diseases - pathology Sex Factors |
| title | Spontaneous myelofibrosis in castrated and ovariectomized NMRI mice |
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