Cephalosporin 3'-quinolone esters with a dual mode of action

According to the generally accepted mechanism by which bacterial enzymes react with cephalosporins, opening of the beta-lactam ring can lead to the expulsion of a 3'-substituent. A series of dual-action cephalosporins was prepared in which antibacterial quinolones were linked to the cephalospor...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-01, Vol.33 (1), p.77-86
Hauptverfasser:	Albrecht, Harry A, Beskid, George, Chan, Ka Kong, Christenson, James G, Cleeland, Roy, Deitcher, Kenneth H, Georgopapadakou, Nafsika H, Keith, Dennis D, Pruess, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cefotaxime - analogs & derivatives Cefotaxime - pharmacology Cephalosporins - chemical synthesis Cephalosporins - pharmacology Cephalosporins - therapeutic use Chemical Phenomena Chemistry Ciprofloxacin - analogs & derivatives Ciprofloxacin - pharmacology Enterobacter - drug effects Escherichia coli Infections - drug therapy Fleroxacin - analogs & derivatives Fluoroquinolones Hydrolysis Medical sciences Mice Molecular Structure Pharmacology. Drug treatments Pneumococcal Infections - drug therapy Prodrugs Quinolones - chemical synthesis Quinolones - pharmacology Quinolones - therapeutic use Rats Staphylococcus aureus - drug effects Structure-Activity Relationship
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