Synthesis and cardiotonic activity of novel biimidazoles

A series of substituted 2,2'-bi-1H-imidazoles and related analogues was synthesized and evaluated for inotropic activity. Structure-activity relationship studies based on a nonclassical bioisosteric approach indicated the necessity of a cyano group on one of the imidazole rings to obtain the de...

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Veröffentlicht in:	Journal of medicinal chemistry 1990-01, Vol.33 (1), p.317-327
Hauptverfasser:	Matthews, Donald P, McCarthy, James R, Whitten, Jeffrey P, Kastner, Philip R, Barney, Charlotte L, Marshall, Franklin N, Ertel, Marcia A, Burkhard, Therese, Shea, Philip J, Kariya, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	2',3'-Cyclic-Nucleotide Phosphodiesterases - antagonists & inhibitors Amrinone - pharmacology Animals Blood Pressure - drug effects Cardiotonic Agents Chemical Phenomena Chemistry Dogs Exact sciences and technology Furans - chemical synthesis Furans - pharmacology Heart Rate - drug effects Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imidazoles - chemical synthesis Imidazoles - pharmacology inotropism Isoenzymes - antagonists & inhibitors Milrinone Molecular Structure Myocardial Contraction - drug effects Organic chemistry Preparations and properties Pyridones - pharmacology Rats Stimulation, Chemical Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - pharmacology Thiophenes - chemical synthesis Thiophenes - pharmacology
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