Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function

Ultraviolet light (UVR) induces a myriad of cutaneous changes, including delayed disruption of the permeability barrier with higher doses. To investigate the basis for the UVB‐induced barrier alteration, we assessed the epidermal lamellar body secretory system at various time points before and after...

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Veröffentlicht in:	Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 1997-08, Vol.13 (4), p.117-128
Hauptverfasser:	Holleran, W. M., Uchida, Y., Halkier-Sorensen, L., Haratake, A., Hara, M., Epstein, J. H., Elias, P. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - metabolism Acyltransferases - radiation effects Animals Biological and medical sciences Cell Count Cell Division - radiation effects ceramides Ceramides - biosynthesis Ceramides - radiation effects Cholesterol - biosynthesis Cholesterol - radiation effects Dermatology epidermal lipid synthesis Epidermis - chemistry Epidermis - radiation effects Epidermis - ultrastructure Fatty Acids - biosynthesis Fatty Acids - radiation effects Follow-Up Studies Hyperplasia Keratinocytes - chemistry Keratinocytes - radiation effects Keratinocytes - ultrastructure lamellar bodies Lipids - biosynthesis Lipids - radiation effects Medical sciences Mice Mice, Hairless Organelles - chemistry Organelles - radiation effects Organelles - secretion Organelles - ultrastructure Permeability - radiation effects permeability barrier Regeneration Serine C-Palmitoyltransferase serine palmitoyltransferase Skin - chemistry Skin - radiation effects Skin - ultrastructure Skin involvement in other diseases. Miscellaneous. General aspects Sphingolipids - biosynthesis Sphingolipids - radiation effects ultrastructure Ultraviolet Rays UVB Vacuoles - chemistry Vacuoles - radiation effects Vacuoles - ultrastructure Water Loss, Insensible - radiation effects
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