Assay and purity analysis of diatrizoate sodium in drug product by LC

An LC procedure was developed to separate diatrizoate sodium from three known impurities. These impurities are 2,4- and 2,6-diiodo-3,5-diacetamidobenzoic acid (DDZA), and the free amine (5-acetamido-3-amino-2,4,6-triiodobenzoic acid). The separation was achieved using a Hamilton, PRP-X100, anion exc...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1997-09, Vol.16 (1), p.39-45
Hauptverfasser:	Chellquist, Eric M., Nelson, William O., Storflor, Harry L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Chemistry, Pharmaceutical Chromatography, Liquid Contrast media Contrast Media - analysis Diatrizoate - analogs & derivatives Diatrizoate - analysis Diatrizoate - isolation & purification Diatrizoate sodium General pharmacology Hydrogen-Ion Concentration Hypaque Ion Exchange Resins Medical sciences Pharmacology. Drug treatments Phosphates Potassium Chloride Potassium Compounds Quality Control Reproducibility of Results
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