Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells

Our recent study demonstrated that aminoglycoside antibiotics are taken up into sensory hair cells of the inner ear by receptor-mediated endocytosis (E. Hashino, M. Shero, Endocytosis of aminoglycoside antibiotics in sensory hair cells, Brain Res. 704 (1995) 135–140). To elucidate the intracellular...

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Veröffentlicht in:	Brain research 1997-11, Vol.777 (1), p.75-85
Hauptverfasser:	Hashino, Eri, Shero, Marlene, Salvi, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycoside Animals Anti-Bacterial Agents - pharmacokinetics Biological Transport - physiology Chicken Chickens Endocytosis Endocytosis - physiology Hair cell Hair Cells, Auditory - cytology Hair Cells, Auditory - drug effects Hair Cells, Auditory - metabolism Immunohistochemistry Kanamycin - pharmacokinetics Lysosome Lysosomes - metabolism Lysosomes - ultrastructure Microscopy, Immunoelectron Toxicity Trafficking
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