C-reactive protein as a marker for acute coronary syndromes
Background For several years, acute coronary syndromes have been perceived as causing the most hospital admissions, and even hospital mortality. The syndrome of unstable angina frequently progresses to acute myocardial infarction but its pathogenesis is poorly understood, and prognosis determination...
Gespeichert in:
| Veröffentlicht in: | European heart journal 1997-12, Vol.18 (12), p.1897-1902 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1902 |
|---|---|
| container_issue | 12 |
| container_start_page | 1897 |
| container_title | European heart journal |
| container_volume | 18 |
| creator | Mach, F. Lovis, C. Gaspoz, J.-M. Unger, P.-F. Bouillie, M. Urban, P. Rutishauser, W. |
| description | Background For several years, acute coronary syndromes have been perceived as causing the most hospital admissions, and even hospital mortality. The syndrome of unstable angina frequently progresses to acute myocardial infarction but its pathogenesis is poorly understood, and prognosis determination is still problematic. We tested the hypothesis that measurement of the C-reactive protein in patients admitted for chest pain could be a marker for acute coronary syndromes. Methods and Results We studied 110 patients admitted with suspected ischaemic heart disease, but without elevated serum creatine-kinase levels at the time of hospital admission. Patients were subsequently divided into two groups based on their final diagnosis: group 1 comprised patients with unstable angina; group 2 patients with acute myocardial infarction. We measured the C-reactive protein at the time of hospital admission. The concentration of C-reactive protein was elevated in 59% of the patients with a final diagnosis of acute myocardial infarction, and in 5% of the patients with a final diagnosis of unstable angina, (P |
| doi_str_mv | 10.1093/oxfordjournals.eurheartj.a015198 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79532445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79532445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-61590ddc23ba15dbb7888a180737da5dc30b02939e6b46cb0d6edad9633b3d703</originalsourceid><addsrcrecordid>eNpVkE9r3DAQxUVpSDdpP0LBhxB68WZkWZJFLylL84cEAiGFpRcxlmapN7tWKtkh--2rsGahpzm8x3tvfox94zDnYMRFeFuF6NdhjD1u0pzG-IcwDus5ApfcNB_YjMuqKo2q5Uc2A25kqVSz_MROUloDQKO4OmbHpq614HrGvi_KSOiG7pWKlxgG6voCU4HFFuMzxSLXFejGgQoXYugx7oq0630MW0qf2dEqr6Av0z1lv65-Pi1uyvuH69vFj_vSSa6HUnFpwHtXiRa59G2rm6ZB3oAW2qP0TkALlRGGVFsr14JX5NEbJUQrvAZxys73uXng35HSYLddcrTZYE9hTFYbKaq6ltl4uTe6GFKKtLIvscuP7CwH-87P_s_PHvjZiV-O-Dp1je2W_CFgApb1s0nH5HCziti7Lh1sFTRGw_uScm_r0kBvBzkztSq_Le3N8rd9fLxTEkxll-Ifid-RnQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79532445</pqid></control><display><type>article</type><title>C-reactive protein as a marker for acute coronary syndromes</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Mach, F. ; Lovis, C. ; Gaspoz, J.-M. ; Unger, P.-F. ; Bouillie, M. ; Urban, P. ; Rutishauser, W.</creator><creatorcontrib>Mach, F. ; Lovis, C. ; Gaspoz, J.-M. ; Unger, P.-F. ; Bouillie, M. ; Urban, P. ; Rutishauser, W.</creatorcontrib><description>Background For several years, acute coronary syndromes have been perceived as causing the most hospital admissions, and even hospital mortality. The syndrome of unstable angina frequently progresses to acute myocardial infarction but its pathogenesis is poorly understood, and prognosis determination is still problematic. We tested the hypothesis that measurement of the C-reactive protein in patients admitted for chest pain could be a marker for acute coronary syndromes. Methods and Results We studied 110 patients admitted with suspected ischaemic heart disease, but without elevated serum creatine-kinase levels at the time of hospital admission. Patients were subsequently divided into two groups based on their final diagnosis: group 1 comprised patients with unstable angina; group 2 patients with acute myocardial infarction. We measured the C-reactive protein at the time of hospital admission. The concentration of C-reactive protein was elevated in 59% of the patients with a final diagnosis of acute myocardial infarction, and in 5% of the patients with a final diagnosis of unstable angina, (P<0·001). Conclusion This study indicates that C-reactive protein levels measured at the time of admission in patients with suspected ischaemic heart disease could be a marker for acute coronary syndromes, and helpful in identifying patients at high risk for acute myocardial infarction. Measurement of C-reactive protein may have practical clinical significance in the management of patients hospitalized for suspected acute coronary syndromes.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a015198</identifier><identifier>PMID: 9447317</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acute coronary syndromes ; Acute Disease ; Aged ; Angina Pectoris - blood ; Angina, Unstable - blood ; Biological and medical sciences ; Biomarkers ; C-reactive protein ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Coronary Disease - blood ; Coronary heart disease ; Creatine Kinase - blood ; Female ; Heart ; Humans ; Isoenzymes ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Syndrome</subject><ispartof>European heart journal, 1997-12, Vol.18 (12), p.1897-1902</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-61590ddc23ba15dbb7888a180737da5dc30b02939e6b46cb0d6edad9633b3d703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2089705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9447317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mach, F.</creatorcontrib><creatorcontrib>Lovis, C.</creatorcontrib><creatorcontrib>Gaspoz, J.-M.</creatorcontrib><creatorcontrib>Unger, P.-F.</creatorcontrib><creatorcontrib>Bouillie, M.</creatorcontrib><creatorcontrib>Urban, P.</creatorcontrib><creatorcontrib>Rutishauser, W.</creatorcontrib><title>C-reactive protein as a marker for acute coronary syndromes</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Background For several years, acute coronary syndromes have been perceived as causing the most hospital admissions, and even hospital mortality. The syndrome of unstable angina frequently progresses to acute myocardial infarction but its pathogenesis is poorly understood, and prognosis determination is still problematic. We tested the hypothesis that measurement of the C-reactive protein in patients admitted for chest pain could be a marker for acute coronary syndromes. Methods and Results We studied 110 patients admitted with suspected ischaemic heart disease, but without elevated serum creatine-kinase levels at the time of hospital admission. Patients were subsequently divided into two groups based on their final diagnosis: group 1 comprised patients with unstable angina; group 2 patients with acute myocardial infarction. We measured the C-reactive protein at the time of hospital admission. The concentration of C-reactive protein was elevated in 59% of the patients with a final diagnosis of acute myocardial infarction, and in 5% of the patients with a final diagnosis of unstable angina, (P<0·001). Conclusion This study indicates that C-reactive protein levels measured at the time of admission in patients with suspected ischaemic heart disease could be a marker for acute coronary syndromes, and helpful in identifying patients at high risk for acute myocardial infarction. Measurement of C-reactive protein may have practical clinical significance in the management of patients hospitalized for suspected acute coronary syndromes.</description><subject>Acute coronary syndromes</subject><subject>Acute Disease</subject><subject>Aged</subject><subject>Angina Pectoris - blood</subject><subject>Angina, Unstable - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - blood</subject><subject>Coronary heart disease</subject><subject>Creatine Kinase - blood</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Isoenzymes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Syndrome</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE9r3DAQxUVpSDdpP0LBhxB68WZkWZJFLylL84cEAiGFpRcxlmapN7tWKtkh--2rsGahpzm8x3tvfox94zDnYMRFeFuF6NdhjD1u0pzG-IcwDus5ApfcNB_YjMuqKo2q5Uc2A25kqVSz_MROUloDQKO4OmbHpq614HrGvi_KSOiG7pWKlxgG6voCU4HFFuMzxSLXFejGgQoXYugx7oq0630MW0qf2dEqr6Av0z1lv65-Pi1uyvuH69vFj_vSSa6HUnFpwHtXiRa59G2rm6ZB3oAW2qP0TkALlRGGVFsr14JX5NEbJUQrvAZxys73uXng35HSYLddcrTZYE9hTFYbKaq6ltl4uTe6GFKKtLIvscuP7CwH-87P_s_PHvjZiV-O-Dp1je2W_CFgApb1s0nH5HCziti7Lh1sFTRGw_uScm_r0kBvBzkztSq_Le3N8rd9fLxTEkxll-Ifid-RnQ</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Mach, F.</creator><creator>Lovis, C.</creator><creator>Gaspoz, J.-M.</creator><creator>Unger, P.-F.</creator><creator>Bouillie, M.</creator><creator>Urban, P.</creator><creator>Rutishauser, W.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>C-reactive protein as a marker for acute coronary syndromes</title><author>Mach, F. ; Lovis, C. ; Gaspoz, J.-M. ; Unger, P.-F. ; Bouillie, M. ; Urban, P. ; Rutishauser, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-61590ddc23ba15dbb7888a180737da5dc30b02939e6b46cb0d6edad9633b3d703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute coronary syndromes</topic><topic>Acute Disease</topic><topic>Aged</topic><topic>Angina Pectoris - blood</topic><topic>Angina, Unstable - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - blood</topic><topic>Coronary heart disease</topic><topic>Creatine Kinase - blood</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Isoenzymes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mach, F.</creatorcontrib><creatorcontrib>Lovis, C.</creatorcontrib><creatorcontrib>Gaspoz, J.-M.</creatorcontrib><creatorcontrib>Unger, P.-F.</creatorcontrib><creatorcontrib>Bouillie, M.</creatorcontrib><creatorcontrib>Urban, P.</creatorcontrib><creatorcontrib>Rutishauser, W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mach, F.</au><au>Lovis, C.</au><au>Gaspoz, J.-M.</au><au>Unger, P.-F.</au><au>Bouillie, M.</au><au>Urban, P.</au><au>Rutishauser, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-reactive protein as a marker for acute coronary syndromes</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>18</volume><issue>12</issue><spage>1897</spage><epage>1902</epage><pages>1897-1902</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Background For several years, acute coronary syndromes have been perceived as causing the most hospital admissions, and even hospital mortality. The syndrome of unstable angina frequently progresses to acute myocardial infarction but its pathogenesis is poorly understood, and prognosis determination is still problematic. We tested the hypothesis that measurement of the C-reactive protein in patients admitted for chest pain could be a marker for acute coronary syndromes. Methods and Results We studied 110 patients admitted with suspected ischaemic heart disease, but without elevated serum creatine-kinase levels at the time of hospital admission. Patients were subsequently divided into two groups based on their final diagnosis: group 1 comprised patients with unstable angina; group 2 patients with acute myocardial infarction. We measured the C-reactive protein at the time of hospital admission. The concentration of C-reactive protein was elevated in 59% of the patients with a final diagnosis of acute myocardial infarction, and in 5% of the patients with a final diagnosis of unstable angina, (P<0·001). Conclusion This study indicates that C-reactive protein levels measured at the time of admission in patients with suspected ischaemic heart disease could be a marker for acute coronary syndromes, and helpful in identifying patients at high risk for acute myocardial infarction. Measurement of C-reactive protein may have practical clinical significance in the management of patients hospitalized for suspected acute coronary syndromes.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9447317</pmid><doi>10.1093/oxfordjournals.eurheartj.a015198</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 1997-12, Vol.18 (12), p.1897-1902 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79532445 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute coronary syndromes Acute Disease Aged Angina Pectoris - blood Angina, Unstable - blood Biological and medical sciences Biomarkers C-reactive protein C-Reactive Protein - analysis Cardiology. Vascular system Coronary Disease - blood Coronary heart disease Creatine Kinase - blood Female Heart Humans Isoenzymes Male Medical sciences Middle Aged Prospective Studies Syndrome |
| title | C-reactive protein as a marker for acute coronary syndromes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T17%3A20%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=C-reactive%20protein%20as%20a%20marker%20for%20acute%20coronary%20syndromes&rft.jtitle=European%20heart%20journal&rft.au=Mach,%20F.&rft.date=1997-12-01&rft.volume=18&rft.issue=12&rft.spage=1897&rft.epage=1902&rft.pages=1897-1902&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/oxfordjournals.eurheartj.a015198&rft_dat=%3Cproquest_cross%3E79532445%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79532445&rft_id=info:pmid/9447317&rfr_iscdi=true |