Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women
The effectiveness of a low-dose oral contraceptive (OC) in suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35μg of ethinyl estradiol and 1mg of...
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| Veröffentlicht in: | Fertility and sterility 1990-01, Vol.53 (1), p.35-39 |
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| creator | Murphy, Ana Alvarez Cropp, Craig S. Smith, Beverly S. Burkman, Ronald T. Zacur, Howard A. |
| description | The effectiveness of a low-dose oral contraceptive (OC) in suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35μg of ethinyl estradiol and 1mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and, 9months of OC use on day 1 to 5 of the OC “cycle”. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3months and are maintained at 6 and 9months. |
| doi_str_mv | 10.1016/S0015-0282(16)53212-9 |
| format | Article |
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Thirty-three women ingested 35μg of ethinyl estradiol and 1mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and, 9months of OC use on day 1 to 5 of the OC “cycle”. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3months and are maintained at 6 and 9months.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)53212-9</identifier><identifier>PMID: 2136834</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adrenal Glands - drug effects ; Adrenal Glands - metabolism ; Adult ; Androgens - blood ; Androstenedione - blood ; Biological and medical sciences ; Birth control ; Contraceptives, Oral - administration & dosage ; Dehydroepiandrosterone - blood ; Dose-Response Relationship, Drug ; Female ; Follicle Stimulating Hormone - blood ; Gonadotropins - blood ; Gynecology. Andrology. Obstetrics ; Hirsutism - metabolism ; Hormonal contraception ; Humans ; Luteinizing Hormone - blood ; Medical sciences ; Ovary - drug effects ; Ovary - metabolism ; Sex Hormone-Binding Globulin - metabolism ; Testosterone - blood</subject><ispartof>Fertility and sterility, 1990-01, Vol.53 (1), p.35-39</ispartof><rights>1990 American Society for Reproductive Medicine</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-2015e272f37de6f4fad34cd16ab002ef92f1d7726076c60f4dd6454cdf71fd323</citedby><cites>FETCH-LOGICAL-c459t-2015e272f37de6f4fad34cd16ab002ef92f1d7726076c60f4dd6454cdf71fd323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)53212-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,4050,4051,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6952226$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2136834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murphy, Ana Alvarez</creatorcontrib><creatorcontrib>Cropp, Craig S.</creatorcontrib><creatorcontrib>Smith, Beverly S.</creatorcontrib><creatorcontrib>Burkman, Ronald T.</creatorcontrib><creatorcontrib>Zacur, Howard A.</creatorcontrib><title>Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>The effectiveness of a low-dose oral contraceptive (OC) in suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35μg of ethinyl estradiol and 1mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and, 9months of OC use on day 1 to 5 of the OC “cycle”. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3months and are maintained at 6 and 9months.</description><subject>Adolescent</subject><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - metabolism</subject><subject>Adult</subject><subject>Androgens - blood</subject><subject>Androstenedione - blood</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Contraceptives, Oral - administration & dosage</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropins - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hirsutism - metabolism</subject><subject>Hormonal contraception</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Testosterone - blood</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtrFDEUgIModVv9CYU8iFRwai6TzM6TSGlVKPhQfQ7Z5GQbmclZk5mu_fem3WFfhUAu5ztJzncIOefskjOuP90xxlXDxFpccP1BScFF078gK66UbpRW8iVZHZHX5LSU34wxzTtxQk4El3ot2xXZX4cAbqIY6ID7xmMBitkO1GGasnWwm-JDPUp0i8l6nDLuYiofqU0-4xaWJS3wl95jHjEB3cTkY9rS7YCbeYiJ1pEw3cdc5gnoHkdIb8irYIcCb5f5jPy6uf559a25_fH1-9WX28a1qp8aUQsA0YkgOw86tMF62TrPtd0wJiD0InDfdUKzTjvNQuu9blUlQseDl0KekfeHe3cZ_8xQJjPG4mAYbAKci-l6JVm3XldQHUCXsZQMwexyHG1-NJyZJ-HmWbh5smnq7lm46Wve-fLAvBnBH7MWwzX-bonb4uwQsk0uliOmeyWE0BX7fMCgyniIkE1xEZIDH3Ptj_EY__ORf27znns</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Murphy, Ana Alvarez</creator><creator>Cropp, Craig S.</creator><creator>Smith, Beverly S.</creator><creator>Burkman, Ronald T.</creator><creator>Zacur, Howard A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199001</creationdate><title>Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women</title><author>Murphy, Ana Alvarez ; Cropp, Craig S. ; Smith, Beverly S. ; Burkman, Ronald T. ; Zacur, Howard A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-2015e272f37de6f4fad34cd16ab002ef92f1d7726076c60f4dd6454cdf71fd323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - metabolism</topic><topic>Adult</topic><topic>Androgens - blood</topic><topic>Androstenedione - blood</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Contraceptives, Oral - administration & dosage</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropins - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hirsutism - metabolism</topic><topic>Hormonal contraception</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Ovary - drug effects</topic><topic>Ovary - metabolism</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murphy, Ana Alvarez</creatorcontrib><creatorcontrib>Cropp, Craig S.</creatorcontrib><creatorcontrib>Smith, Beverly S.</creatorcontrib><creatorcontrib>Burkman, Ronald T.</creatorcontrib><creatorcontrib>Zacur, Howard A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murphy, Ana Alvarez</au><au>Cropp, Craig S.</au><au>Smith, Beverly S.</au><au>Burkman, Ronald T.</au><au>Zacur, Howard A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1990-01</date><risdate>1990</risdate><volume>53</volume><issue>1</issue><spage>35</spage><epage>39</epage><pages>35-39</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>The effectiveness of a low-dose oral contraceptive (OC) in suppressing plasma levels of gonadotropins, ovarian, and adrenal androgens and stimulating sex hormone-binding globulin (SHBG) was evaluated prospectively in nonhirsute women. Thirty-three women ingested 35μg of ethinyl estradiol and 1mg of norethindrone beginning within day 1 to 5 of the menstrual cycle. Baseline levels of luteinizing hormone, follicle-stimulating hormone, total testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEAS), and SHBG were obtained before ingestion of the OC and repeated after 3, 6 and, 9months of OC use on day 1 to 5 of the OC “cycle”. A significant suppression of gonadotropin levels is seen in nonhirsute women. Sex hormone binding globulin is consistently stimulated by the low-dose OC. A significant suppression of T and DHEAS is observed. No change was seen in levels of A. The demonstrated effects become evident at 3months and are maintained at 6 and 9months.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2136834</pmid><doi>10.1016/S0015-0282(16)53212-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adolescent Adrenal Glands - drug effects Adrenal Glands - metabolism Adult Androgens - blood Androstenedione - blood Biological and medical sciences Birth control Contraceptives, Oral - administration & dosage Dehydroepiandrosterone - blood Dose-Response Relationship, Drug Female Follicle Stimulating Hormone - blood Gonadotropins - blood Gynecology. Andrology. Obstetrics Hirsutism - metabolism Hormonal contraception Humans Luteinizing Hormone - blood Medical sciences Ovary - drug effects Ovary - metabolism Sex Hormone-Binding Globulin - metabolism Testosterone - blood |
| title | Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women |
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