Genomic Characterization of a Testis-Specific TFIIS (TCEA2) Gene
There is a family of genes encoding TFIIS-related proteins in human cells. We have focused upon the genomic organization of one family member expressed primarily in the testis. This gene encodes a transcription elongation factor similar to but distinct from that encoded by a previously reported TFII...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1997-12, Vol.46 (3), p.516-519 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Weaver, Zoe A. Kane, Caroline M. |
| description | There is a family of genes encoding TFIIS-related proteins in human cells. We have focused upon the genomic organization of one family member expressed primarily in the testis. This gene encodes a transcription elongation factor similar to but distinct from that encoded by a previously reported TFIIS gene. Also in contrast to the previously reported TFIIS gene, the testis gene contains introns. All exon–intron junction sequences match the consensus GT/AG rule. The gene consists of seven exons and six introns with a total size of approximately 7 kb. The nucleotide sequence of the 5′ flanking region of the testis TFIIS gene contains several potential regulatory factor-binding sites, not all of which are present in the TFIIS gene, whose expression is nearly ubiquitous. Elucidation of the full structure of the testis TFIIS gene should be useful for determining its chromosomal localization and its potential role in the regulation of gene expression in human tissues. |
| doi_str_mv | 10.1006/geno.1997.5073 |
| format | Article |
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We have focused upon the genomic organization of one family member expressed primarily in the testis. This gene encodes a transcription elongation factor similar to but distinct from that encoded by a previously reported TFIIS gene. Also in contrast to the previously reported TFIIS gene, the testis gene contains introns. All exon–intron junction sequences match the consensus GT/AG rule. The gene consists of seven exons and six introns with a total size of approximately 7 kb. The nucleotide sequence of the 5′ flanking region of the testis TFIIS gene contains several potential regulatory factor-binding sites, not all of which are present in the TFIIS gene, whose expression is nearly ubiquitous. Elucidation of the full structure of the testis TFIIS gene should be useful for determining its chromosomal localization and its potential role in the regulation of gene expression in human tissues.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1997.5073</identifier><identifier>PMID: 9441762</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Codon, Initiator ; DNA, Complementary ; Fundamental and applied biological sciences. Psychology ; gene family ; Genes. Genome ; HeLa Cells ; Humans ; Male ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Promoter Regions, Genetic ; Testis - metabolism ; testis-specific expression ; TFIIS ; transcript elongation ; Transcription Factors - genetics ; Transcription Factors, General ; Transcriptional Elongation Factors</subject><ispartof>Genomics (San Diego, Calif.), 1997-12, Vol.46 (3), p.516-519</ispartof><rights>1997 Academic Press</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c96a4e236cbdc8b45cf4dd37ef4f20288341e3d4d7b232d76d139637dc4393e3</citedby><cites>FETCH-LOGICAL-c465t-c96a4e236cbdc8b45cf4dd37ef4f20288341e3d4d7b232d76d139637dc4393e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1997.5073$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2122003$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9441762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weaver, Zoe A.</creatorcontrib><creatorcontrib>Kane, Caroline M.</creatorcontrib><title>Genomic Characterization of a Testis-Specific TFIIS (TCEA2) Gene</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>There is a family of genes encoding TFIIS-related proteins in human cells. We have focused upon the genomic organization of one family member expressed primarily in the testis. This gene encodes a transcription elongation factor similar to but distinct from that encoded by a previously reported TFIIS gene. Also in contrast to the previously reported TFIIS gene, the testis gene contains introns. All exon–intron junction sequences match the consensus GT/AG rule. The gene consists of seven exons and six introns with a total size of approximately 7 kb. The nucleotide sequence of the 5′ flanking region of the testis TFIIS gene contains several potential regulatory factor-binding sites, not all of which are present in the TFIIS gene, whose expression is nearly ubiquitous. Elucidation of the full structure of the testis TFIIS gene should be useful for determining its chromosomal localization and its potential role in the regulation of gene expression in human tissues.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Codon, Initiator</subject><subject>DNA, Complementary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene family</subject><subject>Genes. Genome</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Promoter Regions, Genetic</subject><subject>Testis - metabolism</subject><subject>testis-specific expression</subject><subject>TFIIS</subject><subject>transcript elongation</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors, General</subject><subject>Transcriptional Elongation Factors</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMoWh9bd8IsRHQxNa_JY6cUH4WCi84-pMkdjbQzNZkK-uvN0OJOXN3F-c7h8iF0TvCYYCxuX6HtxkRrOa6wZHtoRLDSpRJc7KMRVkqVsuLsCB2n9I4x1kzRQ3SoOSdS0BG6e8r9VXDF5M1G63qI4dv2oWuLrilsUUPqQyrna3ChyVT9OJ3Oi-t68nBPb4rchVN00NhlgrPdPUH140M9eS5nL0_Tyf2sdFxUfem0sBwoE27hnVrwyjXceyah4Q3FVCnGCTDPvVxQRr0UnjAtmPSOM82AnaCr7ew6dh-b_JVZheRgubQtdJtkpK6oroj-FySC8YyyDI63oItdShEas45hZeOXIdgMas2g1gxqzaA2Fy52y5vFCvwvvnOZ88tdbpOzyyba1oX0i1FCKcbDjNpikG19BogmuQCtAx8iuN74Lvz1wQ8LspHs</recordid><startdate>19971215</startdate><enddate>19971215</enddate><creator>Weaver, Zoe A.</creator><creator>Kane, Caroline M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19971215</creationdate><title>Genomic Characterization of a Testis-Specific TFIIS (TCEA2) Gene</title><author>Weaver, Zoe A. ; Kane, Caroline M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-c96a4e236cbdc8b45cf4dd37ef4f20288341e3d4d7b232d76d139637dc4393e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Codon, Initiator</topic><topic>DNA, Complementary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene family</topic><topic>Genes. Genome</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Promoter Regions, Genetic</topic><topic>Testis - metabolism</topic><topic>testis-specific expression</topic><topic>TFIIS</topic><topic>transcript elongation</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors, General</topic><topic>Transcriptional Elongation Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weaver, Zoe A.</creatorcontrib><creatorcontrib>Kane, Caroline M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weaver, Zoe A.</au><au>Kane, Caroline M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic Characterization of a Testis-Specific TFIIS (TCEA2) Gene</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1997-12-15</date><risdate>1997</risdate><volume>46</volume><issue>3</issue><spage>516</spage><epage>519</epage><pages>516-519</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>There is a family of genes encoding TFIIS-related proteins in human cells. We have focused upon the genomic organization of one family member expressed primarily in the testis. This gene encodes a transcription elongation factor similar to but distinct from that encoded by a previously reported TFIIS gene. Also in contrast to the previously reported TFIIS gene, the testis gene contains introns. All exon–intron junction sequences match the consensus GT/AG rule. The gene consists of seven exons and six introns with a total size of approximately 7 kb. The nucleotide sequence of the 5′ flanking region of the testis TFIIS gene contains several potential regulatory factor-binding sites, not all of which are present in the TFIIS gene, whose expression is nearly ubiquitous. Elucidation of the full structure of the testis TFIIS gene should be useful for determining its chromosomal localization and its potential role in the regulation of gene expression in human tissues.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>9441762</pmid><doi>10.1006/geno.1997.5073</doi><tpages>4</tpages></addata></record> |
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| ispartof | Genomics (San Diego, Calif.), 1997-12, Vol.46 (3), p.516-519 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Base Sequence Biological and medical sciences Codon, Initiator DNA, Complementary Fundamental and applied biological sciences. Psychology gene family Genes. Genome HeLa Cells Humans Male Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic Testis - metabolism testis-specific expression TFIIS transcript elongation Transcription Factors - genetics Transcription Factors, General Transcriptional Elongation Factors |
| title | Genomic Characterization of a Testis-Specific TFIIS (TCEA2) Gene |
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