Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population
This chart review study examined the serum vitamin B12 and folate status of 102 geriatric patients newly admitted to a private psychiatric hospital. Only 3.7% were B12 deficient and 1.3% were folate deficient; 4% were anemic. Nevertheless, those with below-median values of both vitamins had signific...
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| Veröffentlicht in: | Biological psychiatry (1969) 1990-01, Vol.27 (2), p.125-137 |
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| container_end_page | 137 |
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| container_title | Biological psychiatry (1969) |
| container_volume | 27 |
| creator | BELL, I. R EDMAN, J. S MARBY, D. W SATLIN, A DREIER, T LIPTZIN, B COLE, J. O |
| description | This chart review study examined the serum vitamin B12 and folate status of 102 geriatric patients newly admitted to a private psychiatric hospital. Only 3.7% were B12 deficient and 1.3% were folate deficient; 4% were anemic. Nevertheless, those with below-median values of both vitamins had significantly lower Mini-Mental State scores than patients higher in one or both vitamins. Patients with "organic psychosis" with a negative family history for psychiatric disorder had significantly lower B12 levels than those with a positive family history. In major depression, folate levels correlated negatively with age at onset of psychiatric illness and length of hospitalization. These data suggest that (1) biochemically interrelated vitamins such as B12 and folate may exert both a separate and a concomitant influence on affect and cognition; (2) poorer vitamin status may contribute to certain geropsychiatric disorders that begin at a later age and lack a familial predisposition. |
| doi_str_mv | 10.1016/0006-3223(90)90642-F |
| format | Article |
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R ; EDMAN, J. S ; MARBY, D. W ; SATLIN, A ; DREIER, T ; LIPTZIN, B ; COLE, J. O</creator><creatorcontrib>BELL, I. R ; EDMAN, J. S ; MARBY, D. W ; SATLIN, A ; DREIER, T ; LIPTZIN, B ; COLE, J. O</creatorcontrib><description>This chart review study examined the serum vitamin B12 and folate status of 102 geriatric patients newly admitted to a private psychiatric hospital. Only 3.7% were B12 deficient and 1.3% were folate deficient; 4% were anemic. Nevertheless, those with below-median values of both vitamins had significantly lower Mini-Mental State scores than patients higher in one or both vitamins. Patients with "organic psychosis" with a negative family history for psychiatric disorder had significantly lower B12 levels than those with a positive family history. In major depression, folate levels correlated negatively with age at onset of psychiatric illness and length of hospitalization. These data suggest that (1) biochemically interrelated vitamins such as B12 and folate may exert both a separate and a concomitant influence on affect and cognition; (2) poorer vitamin status may contribute to certain geropsychiatric disorders that begin at a later age and lack a familial predisposition.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(90)90642-F</identifier><identifier>PMID: 2294976</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Affective Disorders, Psychotic - blood ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bipolar Disorder - blood ; Cognition Disorders - blood ; Depressive Disorder - blood ; Female ; Folic Acid - blood ; Hospitalization ; Humans ; Length of Stay ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Neurocognitive Disorders - blood ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Retrospective Studies ; Techniques and methods ; Vitamin B 12 - blood</subject><ispartof>Biological psychiatry (1969), 1990-01, Vol.27 (2), p.125-137</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-77c5c42b422b690ea8e9aa63e20cd494ed2bb027ee7b3b2225418cd06d084d323</citedby><cites>FETCH-LOGICAL-c331t-77c5c42b422b690ea8e9aa63e20cd494ed2bb027ee7b3b2225418cd06d084d323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6694783$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2294976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BELL, I. R</creatorcontrib><creatorcontrib>EDMAN, J. S</creatorcontrib><creatorcontrib>MARBY, D. W</creatorcontrib><creatorcontrib>SATLIN, A</creatorcontrib><creatorcontrib>DREIER, T</creatorcontrib><creatorcontrib>LIPTZIN, B</creatorcontrib><creatorcontrib>COLE, J. O</creatorcontrib><title>Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>This chart review study examined the serum vitamin B12 and folate status of 102 geriatric patients newly admitted to a private psychiatric hospital. Only 3.7% were B12 deficient and 1.3% were folate deficient; 4% were anemic. Nevertheless, those with below-median values of both vitamins had significantly lower Mini-Mental State scores than patients higher in one or both vitamins. Patients with "organic psychosis" with a negative family history for psychiatric disorder had significantly lower B12 levels than those with a positive family history. In major depression, folate levels correlated negatively with age at onset of psychiatric illness and length of hospitalization. These data suggest that (1) biochemically interrelated vitamins such as B12 and folate may exert both a separate and a concomitant influence on affect and cognition; (2) poorer vitamin status may contribute to certain geropsychiatric disorders that begin at a later age and lack a familial predisposition.</description><subject>Affective Disorders, Psychotic - blood</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - blood</subject><subject>Cognition Disorders - blood</subject><subject>Depressive Disorder - blood</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neurocognitive Disorders - blood</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Retrospective Studies</subject><subject>Techniques and methods</subject><subject>Vitamin B 12 - blood</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UU1v1DAQtRBVWQr_ACQfUAWHgD32xjE3WrEUqRIX4GpNnElrlI2D7VTqr-Avk91Gexo9vY-R3mPsjRQfpZD1JyFEXSkA9d6KD1bUGqrdM7aRjVEVaAHP2eYkecFe5vxngQZAnrNzAKutqTfs3-9QcB9GfiWB49jxPg5YiOeCZc58IdDPC76jFKf86O8DlhT8QkxYAo0lf-bY9-RLeKBjgI93Yzgif48JfaEUcgk-89hz5A_rvzGOHfXBHzL4FKd5eRvi-Iqd9Thker3eC_Zr9_Xn9U11--Pb9-svt5VXSpbKGL_1GloN0NZWEDZkEWtFIHynraYO2laAITKtagFgq2XjO1F3otGdAnXBLp9ypxT_zpSL24fsaRhwpDhnZ-wWTCPVItRPQp9izol6N6Wwx_TopHCHHdyhZHco2Vnhjju43WJ7u-bP7Z66k2ktfuHfrTxmj0OfcPQhn2R1bbVplPoPYdyS_Q</recordid><startdate>19900115</startdate><enddate>19900115</enddate><creator>BELL, I. R</creator><creator>EDMAN, J. S</creator><creator>MARBY, D. W</creator><creator>SATLIN, A</creator><creator>DREIER, T</creator><creator>LIPTZIN, B</creator><creator>COLE, J. O</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900115</creationdate><title>Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population</title><author>BELL, I. R ; EDMAN, J. S ; MARBY, D. W ; SATLIN, A ; DREIER, T ; LIPTZIN, B ; COLE, J. O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-77c5c42b422b690ea8e9aa63e20cd494ed2bb027ee7b3b2225418cd06d084d323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Affective Disorders, Psychotic - blood</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - blood</topic><topic>Cognition Disorders - blood</topic><topic>Depressive Disorder - blood</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neurocognitive Disorders - blood</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Retrospective Studies</topic><topic>Techniques and methods</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BELL, I. R</creatorcontrib><creatorcontrib>EDMAN, J. S</creatorcontrib><creatorcontrib>MARBY, D. W</creatorcontrib><creatorcontrib>SATLIN, A</creatorcontrib><creatorcontrib>DREIER, T</creatorcontrib><creatorcontrib>LIPTZIN, B</creatorcontrib><creatorcontrib>COLE, J. O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BELL, I. R</au><au>EDMAN, J. S</au><au>MARBY, D. W</au><au>SATLIN, A</au><au>DREIER, T</au><au>LIPTZIN, B</au><au>COLE, J. O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1990-01-15</date><risdate>1990</risdate><volume>27</volume><issue>2</issue><spage>125</spage><epage>137</epage><pages>125-137</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>This chart review study examined the serum vitamin B12 and folate status of 102 geriatric patients newly admitted to a private psychiatric hospital. Only 3.7% were B12 deficient and 1.3% were folate deficient; 4% were anemic. Nevertheless, those with below-median values of both vitamins had significantly lower Mini-Mental State scores than patients higher in one or both vitamins. Patients with "organic psychosis" with a negative family history for psychiatric disorder had significantly lower B12 levels than those with a positive family history. In major depression, folate levels correlated negatively with age at onset of psychiatric illness and length of hospitalization. These data suggest that (1) biochemically interrelated vitamins such as B12 and folate may exert both a separate and a concomitant influence on affect and cognition; (2) poorer vitamin status may contribute to certain geropsychiatric disorders that begin at a later age and lack a familial predisposition.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>2294976</pmid><doi>10.1016/0006-3223(90)90642-F</doi><tpages>13</tpages></addata></record> |
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| subjects | Affective Disorders, Psychotic - blood Aged Aged, 80 and over Biological and medical sciences Bipolar Disorder - blood Cognition Disorders - blood Depressive Disorder - blood Female Folic Acid - blood Hospitalization Humans Length of Stay Male Medical sciences Middle Aged Miscellaneous Neurocognitive Disorders - blood Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Retrospective Studies Techniques and methods Vitamin B 12 - blood |
| title | Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population |
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