T Cell Recognition of Human Pre-Proinsulin Peptides Depends on the Polymorphism at HLA DQ Locus: A Study Using HLA DQ8 and DQ6 Transgenic Mice

HLA DQ8 (DQ A1∗0301/DQB1∗0302) molecule is implicated in the susceptibility to insulin dependent diabetes mellitus whereas, HLA DQ6 (DQ A1∗0103/DQB1∗0601) molecule may have a protective effect. In this study we used mice transgenic to HLA DQ8 and HLA-DQ6 to elucidate the T cell determinants on a put...

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Veröffentlicht in:	Human immunology 1997-11, Vol.58 (1), p.21-29
Hauptverfasser:	Raju, Raghavanpillai, Munn, Stephen R, David, Chella S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Cross Reactions Epitopes, T-Lymphocyte - immunology HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology Humans Insulin Mice Mice, Transgenic Molecular Sequence Data Peptides - immunology Polymorphism, Genetic Proinsulin - immunology Protein Precursors - immunology T-Lymphocytes - immunology
Online-Zugang:	Volltext
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