Efficient Synthesis and Gastric (H+/K+)-ATPase-Inhibitory Activity of 2-Aryl-4, 5-dihydro-1H-thieno[3, 2-e]benzimidazoles

A series of 2-aryl-4, 5-dihydro-1H-thieno[3, 2-e]benzimidazoles (1, 2) was prepared by condensation of 5-acylamino-4, 5, 6, 7-tetrahydrobenzo[b]thiophen-4-ones (9, 10) with ammonium acetate under azeotropic reaction conditions. Various congeners, N-methyl and N-phenyl analogues (3-5), 4, 5-dihydro-1...

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