Psychotropic Drugs and Local Anesthetics Restore Cardiolipin-Inhibited Mammalian DNA Topoisomerase I Activity

The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, s...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1997/12/15, Vol.20(12), pp.1233-1234
Hauptverfasser:	SHAH, Gulzar, KATAOKA, Kazuhiro, UENO, Akiko, OHTSUKA, Yoshihisa, MIZUSHIMA, Tohru, SEKIMIZU, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	acidic phospholipid Anesthetics, Local - pharmacology Animals Antidepressive Agents, Tricyclic - pharmacology Antipsychotic Agents - pharmacology Biological and medical sciences cardiolipin Cardiolipins - pharmacology Cattle Cell Survival - drug effects chlorpromazine Chlorpromazine - pharmacology cytotoxicity DNA topoisomerase I DNA Topoisomerases, Type I - metabolism Hypnotics and Sedatives - pharmacology Imipramine - pharmacology Indicators and Reagents Medical sciences Neuropharmacology Pharmacology. Drug treatments Promethazine - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic Drugs - pharmacology Thymus Gland - enzymology Topoisomerase I Inhibitors
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