Psychotropic Drugs and Local Anesthetics Restore Cardiolipin-Inhibited Mammalian DNA Topoisomerase I Activity

The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, s...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1997/12/15, Vol.20(12), pp.1233-1234
Hauptverfasser:	SHAH, Gulzar, KATAOKA, Kazuhiro, UENO, Akiko, OHTSUKA, Yoshihisa, MIZUSHIMA, Tohru, SEKIMIZU, Kazuhisa
Format:	Artikel
Sprache:	eng
Schlagworte:	acidic phospholipid Anesthetics, Local - pharmacology Animals Antidepressive Agents, Tricyclic - pharmacology Antipsychotic Agents - pharmacology Biological and medical sciences cardiolipin Cardiolipins - pharmacology Cattle Cell Survival - drug effects chlorpromazine Chlorpromazine - pharmacology cytotoxicity DNA topoisomerase I DNA Topoisomerases, Type I - metabolism Hypnotics and Sedatives - pharmacology Imipramine - pharmacology Indicators and Reagents Medical sciences Neuropharmacology Pharmacology. Drug treatments Promethazine - pharmacology Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic Drugs - pharmacology Thymus Gland - enzymology Topoisomerase I Inhibitors
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Zusammenfassung:	The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.20.1233