Synthesis, Structure, Dopamine Transporter Affinity, and Dopamine Uptake Inhibition of 6-Alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane Derivatives

A series of 6-alkyl-3β-benzyl-2-[(methoxycarbonyl)methyl]tropane analogues were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter (DAT). The in vitro affinity (K i) for the DAT of the 6-alkyl-3β-benzyl-2-[(methoxycarbonyl)methyl]tropane analogues was determined by...

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Veröffentlicht in:	Journal of medicinal chemistry 1997-12, Vol.40 (26), p.4406-4414
Hauptverfasser:	Lomenzo, Stacey A, Izenwasser, Sari, Katz, Jonathan L, Terry, Phyllis D, Zhu, Naijue, Klein, Cheryl L, Trudell, Mark L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Binding, Competitive Biological and medical sciences Brain - metabolism Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cocaine - analogs & derivatives Cocaine - metabolism Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Dopamine Uptake Inhibitors - chemical synthesis Dopamine Uptake Inhibitors - chemistry Dopamine Uptake Inhibitors - metabolism Dopamine Uptake Inhibitors - pharmacology Drug addictions Magnetic Resonance Spectroscopy Medical sciences Membrane Glycoproteins Membrane Transport Proteins Molecular Structure Nerve Tissue Proteins Rats Toxicology Tropanes - chemical synthesis Tropanes - chemistry Tropanes - metabolism Tropanes - pharmacology
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