T-cell activation induced by anti-CD3 x anti-B-cell lymphoma monoclonal antibody is enhanced by pretreatment of lymphoma cells with soluble CD40 ligand

T cells play a key role in the control of abnormal B cell proliferation. Factors that play a role in inadequate T cell responses include absence of expression of costimulatory and adhesion molecules by the malignant B cells and lack of cytotoxic T cells specific for tumor-associated antigens. A numb...

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Veröffentlicht in:Cancer immunology and immunotherapy 1997-11, Vol.45 (3-4), p.174-179
Hauptverfasser: WOOLDRIDGE, J. E, DAHLE, C. E, WEINER, G. J
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Sprache:eng
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