Fibroblasts That Overexpress 15-Lipoxygenase Generate Bioactive and Minimally Modified LDL

Several lines of evidence suggest that the cellular enzyme 15 lipoxygenase (15-LO) may be important in promoting the oxidation of lipoproteins in vivo. In previous studies we have shown that fibroblasts transfected with 15-LO "seed" LDL with lipoperoxides such that subsequent oxidation rea...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1997-12, Vol.17 (12), p.3639-3645
Hauptverfasser:	Sigari, Farhad, Lee, Chris, Witztum, Joseph L, Reaven, Peter D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Arachidonate 15-Lipoxygenase - metabolism Arteriosclerosis - etiology Biological and medical sciences Cell Adhesion Cells, Cultured Chemotaxis, Leukocyte Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Lipid Peroxides - metabolism Lipoproteins, LDL - metabolism Lipoproteins, myelin Mice Monocytes - cytology Monocytes - physiology Proteins
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