The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans

We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1997-12, Vol.7 (6), p.777-790
Hauptverfasser:	Okamura, K, Ototake, M, Nakanishi, T, Kurosawa, Y, Hashimoto, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Base Sequence Blotting, Southern Chromosome Mapping DNA, Complementary Genes, MHC Class I Humans Jaw Molecular Sequence Data Mosaicism Polymorphism, Genetic Recombination, Genetic Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Sharks - genetics Sharks - immunology Species Specificity
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